MRX11_YEAST
ID MRX11_YEAST Reviewed; 207 AA.
AC Q03079; D6W3X2; Q6LE92;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=MIOREX complex component 11 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 11 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX11 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YPL041C {ECO:0000312|SGD:S000005962};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Chen E., Bretscher A.P.;
RT "The LAF1 open reading frame encodes a second isoleucyl tRNA synthetase in
RT the yeast Saccharomyces cerevisiae.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000255}.
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DR EMBL; L32174; AAT01100.1; -; Genomic_DNA.
DR EMBL; U44030; AAB68179.1; -; Genomic_DNA.
DR EMBL; AY558328; AAS56654.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11388.1; -; Genomic_DNA.
DR PIR; S62034; S62034.
DR RefSeq; NP_015284.1; NM_001183855.1.
DR AlphaFoldDB; Q03079; -.
DR BioGRID; 36138; 169.
DR STRING; 4932.YPL041C; -.
DR MaxQB; Q03079; -.
DR PaxDb; Q03079; -.
DR PRIDE; Q03079; -.
DR EnsemblFungi; YPL041C_mRNA; YPL041C; YPL041C.
DR GeneID; 856066; -.
DR KEGG; sce:YPL041C; -.
DR SGD; S000005962; MRX11.
DR VEuPathDB; FungiDB:YPL041C; -.
DR eggNOG; ENOG502S09K; Eukaryota.
DR HOGENOM; CLU_071379_3_0_1; -.
DR InParanoid; Q03079; -.
DR OMA; QYELPLY; -.
DR BioCyc; YEAST:G3O-33955-MON; -.
DR PRO; PR:Q03079; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q03079; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR InterPro; IPR018811; Mrx11.
DR PANTHER; PTHR28002; PTHR28002; 2.
DR Pfam; PF10306; FLILHELTA; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 47..207
FT /note="MIOREX complex component 11"
FT /id="PRO_0000238638"
FT TOPO_DOM 47..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:16847258"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..177
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305|PubMed:16847258"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..207
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:16847258"
FT CONFLICT 108..112
FT /note="ILPLF -> NTTTV (in Ref. 1; AAT01100)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 24166 MW; FBB5FE92EDCA2301 CRC64;
MTVMNLFFRP CQLQMGSGPL ELMLKRPTQL TTFMNTRPGG STQIRFISGN LDPVKRREDR
LRKIFSKSRL LTRLNKNPKF SHYFDRLSEA GTVPTLTSFF ILHEVTAILP LFLLWWLLYN
LDLSDDFKLP NFLNGLMDSC HTAMEKFVGK RYQECLNKNK LILSGTVAYV TVKLLYPVRI
FISIWGAPYF GKWLLLPFQK LKHLIKK
