MRX1_YEAST
ID MRX1_YEAST Reviewed; 688 AA.
AC P40050; D3DLY3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=MIOREX complex component 1 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 1 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX1 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YER077C {ECO:0000312|SGD:S000000879};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U18839; AAB64632.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07737.1; -; Genomic_DNA.
DR PIR; S50580; S50580.
DR RefSeq; NP_011000.1; NM_001178968.1.
DR AlphaFoldDB; P40050; -.
DR BioGRID; 36822; 33.
DR DIP; DIP-5353N; -.
DR IntAct; P40050; 3.
DR STRING; 4932.YER077C; -.
DR MaxQB; P40050; -.
DR PaxDb; P40050; -.
DR PRIDE; P40050; -.
DR EnsemblFungi; YER077C_mRNA; YER077C; YER077C.
DR GeneID; 856810; -.
DR KEGG; sce:YER077C; -.
DR SGD; S000000879; MRX1.
DR VEuPathDB; FungiDB:YER077C; -.
DR eggNOG; ENOG502QSY4; Eukaryota.
DR HOGENOM; CLU_029536_0_0_1; -.
DR InParanoid; P40050; -.
DR OMA; PLSHWNI; -.
DR BioCyc; YEAST:G3O-30248-MON; -.
DR PRO; PR:P40050; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P40050; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR002885; Pentatricopeptide_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF13041; PPR_2; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 47..688
FT /note="MIOREX complex component 1"
FT /id="PRO_0000202635"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 79548 MW; 44C9EDC2E3D24E4F CRC64;
MGLKITKGQL RTKDLNQSSS KSSQSSRIGV DTCIFTRMLP RINTAINLTE HLLRRSFHSL
TNLQKTQVKE RLHELERHGF ILNKTSKQLE RINSKKRRQL KKLQKTAYPK DQAFHILRKF
HKINNEALAD TKLGPTSQSD LKFLSLTKDK RLFYTILGVN GEQLRDSKLI ANDVQKFLKR
GQLEKAVFLA RLAKKKGVVG MNLIMKYYIE VVQSQQSAVD IFNWRKKWGV PIDQHSITIL
FNGLSKQENL VSKKYGELVL KTIDSLCDKN ELTEIEYNTA LAALINCTDE TLVFKLLNKK
CPGLKKDSIT YTLMIRSCTR IADEKRFMVV LNDLMNKIPD YCVDSKLLFE YCEVICSQKS
PKIEKQGMGL WALCEYFQFD KTIFKKYLTQ SDFPTLVPLS HWNINKPFPL NKHVVGLFMN
YCLKNKEYDL AMEIFKTLEA QNNQMLDQSI YHKYMETVIT TRPITCGDEC LDIYERVASS
AQISITRRTL ILVYNAFQRQ SLKAVINKDA SNAEATLHKI RGFIDSVEAT YSSKLNGKVY
RFNSWKFLFP IVKNLNMNDK VSTVELKSIL DEYLKSLLNG EFGKEFKASI EDKRFVTLEG
IRLVKVLTER IKLPSLDSEE IASLKGTERK KFLARRHLLR LKQILLEDLA DIEGNSRRKG
DSENTSTSEE RIMEDLAELI LETSYDKF
