MRX3_YEAST
ID MRX3_YEAST Reviewed; 270 AA.
AC P38172; D6VPQ9;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=MIOREX complex component 3 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 3 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX3 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YBL095W {ECO:0000312|SGD:S000000191}; ORFNames=YBL0835;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7502586; DOI=10.1002/yea.320111112;
RA Obermaier B., Gassenhuber J., Piravandi E., Domdey H.;
RT "Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces
RT cerevisiae chromosome II.";
RL Yeast 11:1103-1112(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
RN [8]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16823961}.
CC -!- MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X79489; CAA56007.1; -; Genomic_DNA.
DR EMBL; Z35857; CAA84917.1; -; Genomic_DNA.
DR EMBL; AY558565; AAS56891.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07029.1; -; Genomic_DNA.
DR PIR; S45407; S45407.
DR RefSeq; NP_009457.1; NM_001178335.1.
DR AlphaFoldDB; P38172; -.
DR SMR; P38172; -.
DR BioGRID; 32609; 64.
DR DIP; DIP-4588N; -.
DR IntAct; P38172; 2.
DR STRING; 4932.YBL095W; -.
DR MaxQB; P38172; -.
DR PaxDb; P38172; -.
DR PRIDE; P38172; -.
DR EnsemblFungi; YBL095W_mRNA; YBL095W; YBL095W.
DR GeneID; 852181; -.
DR KEGG; sce:YBL095W; -.
DR SGD; S000000191; MRX3.
DR VEuPathDB; FungiDB:YBL095W; -.
DR eggNOG; KOG4781; Eukaryota.
DR HOGENOM; CLU_052827_2_2_1; -.
DR InParanoid; P38172; -.
DR OMA; PKWFKYL; -.
DR BioCyc; YEAST:G3O-28982-MON; -.
DR PRO; PR:P38172; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38172; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR Pfam; PF03061; 4HBT; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..12
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 13..270
FT /note="MIOREX complex component 3"
FT /id="PRO_0000202441"
SQ SEQUENCE 270 AA; 30545 MW; 76DD3249586A2A0E CRC64;
MSRTIPFLFK LVNRAVILPT AGFTLGVGAF VKAWPDDAGV LSLNDPQTPA ELISATKSRQ
PMELQRVDIL AQIEKSEVYN KLAQDEKMHH VLFSEKIPSG HREYHVGQGL LFGKGKLEID
PLVFHDVNHG ELTVIYHLGA ELGNRDGNVH KGLLSLLLDE ALCYCGFPLL PSKRGVTARL
SLEFFEDIPV DTTIILKANV KEIKGRKCII EGHLEQFPLE VSSRNGTRSW NLPHIWGFNH
KQEMAKKFAK ANCILVEPTW FKYFKWLDMF
