MRX5_YEAST
ID MRX5_YEAST Reviewed; 382 AA.
AC P47007; D6VW38;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=MIOREX complex component 5 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 5 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX5 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YJL147C {ECO:0000312|SGD:S000003683}; ORFNames=J0639;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8813765;
RX DOI=10.1002/(sici)1097-0061(19960630)12:8<787::aid-yea954>3.0.co;2-4;
RA Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.;
RT "Sequence analysis of a 40.7 kb segment from the left arm of yeast
RT chromosome X reveals 14 known genes and 13 new open reading frames
RT including homologues of genes clustered on the right arm of chromosome
RT XI.";
RL Yeast 12:787-797(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 981 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z49422; CAA89442.1; -; Genomic_DNA.
DR EMBL; X87371; CAA60808.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08654.1; -; Genomic_DNA.
DR PIR; S55166; S55166.
DR RefSeq; NP_012388.1; NM_001181580.1.
DR AlphaFoldDB; P47007; -.
DR SMR; P47007; -.
DR BioGRID; 33611; 215.
DR IntAct; P47007; 29.
DR MINT; P47007; -.
DR STRING; 4932.YJL147C; -.
DR PaxDb; P47007; -.
DR PRIDE; P47007; -.
DR EnsemblFungi; YJL147C_mRNA; YJL147C; YJL147C.
DR GeneID; 853294; -.
DR KEGG; sce:YJL147C; -.
DR SGD; S000003683; MRX5.
DR VEuPathDB; FungiDB:YJL147C; -.
DR eggNOG; ENOG502RYWP; Eukaryota.
DR HOGENOM; CLU_061864_0_0_1; -.
DR InParanoid; P47007; -.
DR OMA; YQYRFIR; -.
DR BioCyc; YEAST:G3O-31591-MON; -.
DR PRO; PR:P47007; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47007; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..12
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 13..382
FT /note="MIOREX complex component 5"
FT /id="PRO_0000203032"
SQ SEQUENCE 382 AA; 44863 MW; DDAAF588AF9A3234 CRC64;
MRRTFSQLAT RLLKSKDDEL KSTLKYLTKG PVKLLGPLFE SSEVNEQGSL LNRSRTKENN
LQNHHIENIL RILNSNLPEV ESKKQKVAVH YDVLFSHLNS IVTQATDNKS SSSKELQGSS
SEDLYDRLLL LQYVGKLTNV RQITEILLSK KFNKFDKVWE HRALFDEYQR VVISILLYYR
THDVQIRKDY EPRWLSDYSD LPFPLRRLLW RCLTSNVSED NIRQNIIHYI KLLGANWRNN
DLILIYQSLY EKSHILPDLT VLNHNKDDGF SFTQNQILLV RILRAISKCV EEEPKLVKKW
LIDIVKLSIQ SKIMLESPKK PSTPIMDQYK FIRSLDISIR SIHRTCQDKL IFEDLQVNLG
SVLKMINEEE HELKTHLPLN LI
