MRX6_YEAST
ID MRX6_YEAST Reviewed; 524 AA.
AC P48564; D6W0P8;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=MIOREX complex component 6 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 6 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX6 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YNL295W {ECO:0000312|SGD:S000005239}; ORFNames=N0462;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8553702; DOI=10.1002/yea.320111311;
RA Maurer K.C.T., Urbanus J.H.M., Planta R.J.;
RT "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV
RT carrying a ribosomal protein gene cluster, the genes encoding a plasma
RT membrane protein and a subunit of replication factor C, and a novel
RT putative serine/threonine protein kinase gene.";
RL Yeast 11:1303-1310(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:25683707}.
CC -!- MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U23084; AAC49104.1; -; Genomic_DNA.
DR EMBL; Z71571; CAA96213.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10264.1; -; Genomic_DNA.
DR PIR; S60406; S60406.
DR RefSeq; NP_014104.1; NM_001183133.1.
DR AlphaFoldDB; P48564; -.
DR BioGRID; 35542; 38.
DR IntAct; P48564; 3.
DR MINT; P48564; -.
DR STRING; 4932.YNL295W; -.
DR MaxQB; P48564; -.
DR PaxDb; P48564; -.
DR PRIDE; P48564; -.
DR EnsemblFungi; YNL295W_mRNA; YNL295W; YNL295W.
DR GeneID; 855421; -.
DR KEGG; sce:YNL295W; -.
DR SGD; S000005239; MRX6.
DR VEuPathDB; FungiDB:YNL295W; -.
DR eggNOG; ENOG502R6CM; Eukaryota.
DR HOGENOM; CLU_555750_0_0_1; -.
DR InParanoid; P48564; -.
DR OMA; PVIPWDA; -.
DR BioCyc; YEAST:G3O-33284-MON; -.
DR PRO; PR:P48564; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P48564; protein.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0090144; P:mitochondrial nucleoid organization; IMP:SGD.
DR GO; GO:1901858; P:regulation of mitochondrial DNA metabolic process; IMP:SGD.
DR InterPro; IPR014804; Pet20-like.
DR Pfam; PF08692; Pet20; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..34
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 35..524
FT /note="MIOREX complex component 6"
FT /id="PRO_0000203374"
FT REGION 29..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 61228 MW; AC40CEE9ECB23BC5 CRC64;
MEHQALRRLV LYCPNFIRRG ALRQNMTRVS CRHMSGKGGG RDEKGDCNEE KDSSKDLGRV
PSKMKRAYDG ETVIKEGDSH AESLAQQGKQ PTDLAYNSRS KISGSNLHLL VPRVASTDYI
SNKEVHTEGL FAGYRPLFLG NSGFPSDARK GKNFHELDDV LPNIQVVDAS EKDGKLNVQE
IIEDLQRTSL RESIHSMEQL PSSHKRKPVI PWDASISGMV YNDMPFKYVP KNIILKMKPF
KLLRIERKSQ AKNARKPTMI KLQFHNRRIN DTPELVNLYH NKSRLHESLY NTKPLQESGY
SSANTSKRQK MLKARSDFEH KQKNYAYKHT FIKNDQELFR NELTKLNKIL AREFKKLTKL
SIHNEFKREH LPLAVYVSKS KGTKKLFRRS LKMKIMDHIY PVYTTILSTL TNSRDSKKFE
NKIKAYIEKI IVRLSDEVPS TYFFQDGVDC IIQPSPIHNF KRMHWLRYTK RHNTFWGRTI
HKDVQVSFND KYVVTRSGVR YTRYPTNLNT QLLETAFEEW DYYE
