MS18A_PANTR
ID MS18A_PANTR Reviewed; 232 AA.
AC Q68UT5;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Protein Mis18-alpha;
GN Name=MIS18A;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paeaebo S., Reinhardt R., Zheng H.-J., Zhang X.-L.,
RA Zhu G.-F., Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S.,
RA Cheong J.-E., Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F.,
RA Kim C.-G., Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S.,
RA Wang S.-Y., Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
CC -!- FUNCTION: Required for recruitment of CENPA to centromeres and normal
CC chromosome segregation during mitosis. {ECO:0000250|UniProtKB:Q9NYP9}.
CC -!- SUBUNIT: Homodimer, and heterodimer with OIP5/MIS18B. Identified in a
CC complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4.
CC {ECO:0000250|UniProtKB:Q9NYP9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NYP9}.
CC Chromosome {ECO:0000250|UniProtKB:Q9NYP9}. Chromosome, centromere
CC {ECO:0000250|UniProtKB:Q9NYP9}. Note=Associated with centromeres in
CC interphase cells, from late anaphase to the G1 phase. Not detected on
CC centromeres during earlier phases of mitosis. Associated with
CC chromatin. {ECO:0000250|UniProtKB:Q9NYP9}.
CC -!- SIMILARITY: Belongs to the mis18 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01129}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL954205; CAH18576.1; -; Genomic_DNA.
DR RefSeq; NP_001065279.1; NM_001071811.1.
DR AlphaFoldDB; Q68UT5; -.
DR STRING; 9598.ENSPTRP00000053994; -.
DR PaxDb; Q68UT5; -.
DR Ensembl; ENSPTRT00000025830; ENSPTRP00000053994; ENSPTRG00000013850.
DR GeneID; 473952; -.
DR KEGG; ptr:473952; -.
DR CTD; 54069; -.
DR VGNC; VGNC:1138; MIS18A.
DR eggNOG; ENOG502S9R8; Eukaryota.
DR GeneTree; ENSGT00940000154267; -.
DR HOGENOM; CLU_101031_0_0_1; -.
DR InParanoid; Q68UT5; -.
DR OMA; EMKMLVM; -.
DR OrthoDB; 1453138at2759; -.
DR TreeFam; TF333200; -.
DR Proteomes; UP000002277; Chromosome 21.
DR Bgee; ENSPTRG00000013850; Expressed in fibroblast and 18 other tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0044030; P:regulation of DNA methylation; IEA:Ensembl.
DR InterPro; IPR034752; Mis18.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51793; MIS18; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Isopeptide bond;
KW Metal-binding; Mitosis; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation; Zinc.
FT CHAIN 1..232
FT /note="Protein Mis18-alpha"
FT /id="PRO_0000079516"
FT DOMAIN 79..177
FT /note="Mis18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 84
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 143
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYP9"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYP9"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYP9"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYP9"
FT CROSSLNK 161
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9NYP9"
SQ SEQUENCE 232 AA; 25832 MW; 6549B8BE369245E7 CRC64;
MAGVRSLRCS RGCAGGCECG DKGKCRDSSL LGKRLSEDSS RHQLLQKWAS MWSSMSEDAS
VADMERARLE EAAAAEERPL VFLCSGCRRP LGDSLSWVAS QEDTNCILLR CVSCNVSVDK
EQKLSKREKE NGCVLETLCC AGCSLNLGYV YRCTPKNLDY KRDLFCLSVE AIESYVLGSS
EKQIVSEDKE LFNLESRVEI EKSLTQMEDV LKALQMKLWE AESKLSFATC KS
