MS18B_HUMAN
ID MS18B_HUMAN Reviewed; 229 AA.
AC O43482; Q96BX7;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2002, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Protein Mis18-beta;
DE AltName: Full=Cancer/testis antigen 86;
DE Short=CT86;
DE AltName: Full=Opa-interacting protein 5 {ECO:0000303|PubMed:9466265};
DE Short=OIP-5 {ECO:0000303|PubMed:9466265};
GN Name=OIP5 {ECO:0000303|PubMed:9466265}; Synonyms=MIS18B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBUNIT.
RX PubMed=9466265; DOI=10.1046/j.1365-2958.1998.00670.x;
RA Williams J.M., Chen G.-C., Zhu L., Rest R.F.;
RT "Using the yeast two-hybrid system to identify human epithelial cell
RT proteins that bind gonococcal Opa proteins: intracellular gonococci bind
RT pyruvate kinase via their Opa proteins and require host pyruvate for
RT growth.";
RL Mol. Microbiol. 27:171-186(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY,
RP INTERACTION WITH MIS18A, AND IDENTIFICATION IN A COMPLEX CONTAINING MIS18A;
RP MIS18B; MIS18BP1; RBBP7 AND RBBP4.
RX PubMed=17199038; DOI=10.1016/j.devcel.2006.11.002;
RA Fujita Y., Hayashi T., Kiyomitsu T., Toyoda Y., Kokubu A., Obuse C.,
RA Yanagida M.;
RT "Priming of centromere for CENP-A recruitment by human hMis18alpha,
RT hMis18beta, and M18BP1.";
RL Dev. Cell 12:17-30(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; THR-221 AND SER-225, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-221 AND SER-225, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; THR-221 AND SER-225, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP SUBUNIT, AND MUTAGENESIS OF VAL-77 AND TYR-172.
RX PubMed=26921242; DOI=10.15252/embr.201541520;
RA Subramanian L., Medina-Pritchard B., Barton R., Spiller F.,
RA Kulasegaran-Shylini R., Radaviciute G., Allshire R.C.,
RA Arockia Jeyaprakash A.;
RT "Centromere localization and function of Mis18 requires Yippee-like domain-
RT mediated oligomerization.";
RL EMBO Rep. 17:496-507(2016).
CC -!- FUNCTION: Required for recruitment of CENPA to centromeres and normal
CC chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.
CC -!- SUBUNIT: Homodimer, and heterodimer with MIS18A (PubMed:17199038,
CC PubMed:26921242). Identified in a complex containing MIS18A,
CC OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer
CC membrane protein OpaP from Neisseria gonorrhoeae (in vitro)
CC (PubMed:9466265). {ECO:0000269|PubMed:17199038,
CC ECO:0000269|PubMed:26921242, ECO:0000269|PubMed:9466265}.
CC -!- INTERACTION:
CC O43482; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-536879, EBI-2809489;
CC O43482; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-536879, EBI-11096309;
CC O43482; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-536879, EBI-742038;
CC O43482; P21549: AGXT; NbExp=3; IntAct=EBI-536879, EBI-727098;
CC O43482; Q92870-2: APBB2; NbExp=3; IntAct=EBI-536879, EBI-21535880;
CC O43482; O75934: BCAS2; NbExp=3; IntAct=EBI-536879, EBI-1050106;
CC O43482; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-536879, EBI-745073;
CC O43482; Q13515: BFSP2; NbExp=3; IntAct=EBI-536879, EBI-10229433;
CC O43482; Q8TDH9: BLOC1S5; NbExp=3; IntAct=EBI-536879, EBI-465861;
CC O43482; Q6P1W5: C1orf94; NbExp=6; IntAct=EBI-536879, EBI-946029;
CC O43482; Q9H1P6: C20orf85; NbExp=3; IntAct=EBI-536879, EBI-12155483;
CC O43482; Q8N865: C7orf31; NbExp=3; IntAct=EBI-536879, EBI-10174456;
CC O43482; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-536879, EBI-11524851;
CC O43482; O60826: CCDC22; NbExp=3; IntAct=EBI-536879, EBI-3943153;
CC O43482; Q8N4L8: CCDC24; NbExp=5; IntAct=EBI-536879, EBI-1104933;
CC O43482; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-536879, EBI-10175300;
CC O43482; Q86X02: CDR2L; NbExp=3; IntAct=EBI-536879, EBI-11063830;
CC O43482; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-536879, EBI-743488;
CC O43482; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-536879, EBI-11752486;
CC O43482; Q8TCT0: CERK; NbExp=3; IntAct=EBI-536879, EBI-10274247;
CC O43482; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-536879, EBI-2321769;
CC O43482; P10606: COX5B; NbExp=3; IntAct=EBI-536879, EBI-1053725;
CC O43482; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-536879, EBI-739773;
CC O43482; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-536879, EBI-11962928;
CC O43482; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-536879, EBI-9679045;
CC O43482; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-536879, EBI-465804;
CC O43482; Q86UW9: DTX2; NbExp=3; IntAct=EBI-536879, EBI-740376;
CC O43482; Q9H596: DUSP21; NbExp=3; IntAct=EBI-536879, EBI-7357329;
CC O43482; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-536879, EBI-743105;
CC O43482; Q9NRA8: EIF4ENIF1; NbExp=3; IntAct=EBI-536879, EBI-301024;
CC O43482; Q96DF8: ESS2; NbExp=3; IntAct=EBI-536879, EBI-3928124;
CC O43482; Q9NYK6-3: EURL; NbExp=3; IntAct=EBI-536879, EBI-13371226;
CC O43482; Q96MY7: FAM161B; NbExp=4; IntAct=EBI-536879, EBI-7225287;
CC O43482; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-536879, EBI-2807642;
CC O43482; P22607: FGFR3; NbExp=3; IntAct=EBI-536879, EBI-348399;
CC O43482; A1L4K1: FSD2; NbExp=3; IntAct=EBI-536879, EBI-5661036;
CC O43482; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-536879, EBI-372506;
CC O43482; Q96CN9: GCC1; NbExp=3; IntAct=EBI-536879, EBI-746252;
CC O43482; P55040: GEM; NbExp=3; IntAct=EBI-536879, EBI-744104;
CC O43482; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-536879, EBI-7251368;
CC O43482; O95872: GPANK1; NbExp=3; IntAct=EBI-536879, EBI-751540;
CC O43482; Q13227: GPS2; NbExp=5; IntAct=EBI-536879, EBI-713355;
CC O43482; Q14957: GRIN2C; NbExp=3; IntAct=EBI-536879, EBI-8285963;
CC O43482; P28799: GRN; NbExp=3; IntAct=EBI-536879, EBI-747754;
CC O43482; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-536879, EBI-11956675;
CC O43482; O14964: HGS; NbExp=3; IntAct=EBI-536879, EBI-740220;
CC O43482; P09067: HOXB5; NbExp=3; IntAct=EBI-536879, EBI-3893317;
CC O43482; P17482: HOXB9; NbExp=3; IntAct=EBI-536879, EBI-745290;
CC O43482; P31273: HOXC8; NbExp=3; IntAct=EBI-536879, EBI-1752118;
CC O43482; P01112: HRAS; NbExp=3; IntAct=EBI-536879, EBI-350145;
CC O43482; Q9ULV5-2: HSF4; NbExp=5; IntAct=EBI-536879, EBI-12056251;
CC O43482; Q14005-2: IL16; NbExp=3; IntAct=EBI-536879, EBI-17178971;
CC O43482; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-536879, EBI-2556193;
CC O43482; O60333-2: KIF1B; NbExp=3; IntAct=EBI-536879, EBI-10975473;
CC O43482; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-536879, EBI-8472129;
CC O43482; O14901: KLF11; NbExp=3; IntAct=EBI-536879, EBI-948266;
CC O43482; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-536879, EBI-6426443;
CC O43482; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-536879, EBI-739890;
CC O43482; Q9Y448: KNSTRN; NbExp=3; IntAct=EBI-536879, EBI-373334;
CC O43482; P02533: KRT14; NbExp=3; IntAct=EBI-536879, EBI-702178;
CC O43482; P19012: KRT15; NbExp=4; IntAct=EBI-536879, EBI-739566;
CC O43482; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-536879, EBI-3044087;
CC O43482; P12035: KRT3; NbExp=3; IntAct=EBI-536879, EBI-2430095;
CC O43482; Q92764: KRT35; NbExp=3; IntAct=EBI-536879, EBI-1058674;
CC O43482; O76014: KRT37; NbExp=3; IntAct=EBI-536879, EBI-1045716;
CC O43482; Q6A162: KRT40; NbExp=3; IntAct=EBI-536879, EBI-10171697;
CC O43482; P04259: KRT6B; NbExp=3; IntAct=EBI-536879, EBI-740907;
CC O43482; O95678: KRT75; NbExp=5; IntAct=EBI-536879, EBI-2949715;
CC O43482; Q14533: KRT81; NbExp=5; IntAct=EBI-536879, EBI-739648;
CC O43482; P78385: KRT83; NbExp=3; IntAct=EBI-536879, EBI-10221390;
CC O43482; O43790: KRT86; NbExp=3; IntAct=EBI-536879, EBI-9996498;
CC O43482; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-536879, EBI-11953846;
CC O43482; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-536879, EBI-1048945;
CC O43482; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-536879, EBI-12805508;
CC O43482; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-536879, EBI-726510;
CC O43482; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-536879, EBI-394607;
CC O43482; O14770-4: MEIS2; NbExp=3; IntAct=EBI-536879, EBI-8025850;
CC O43482; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-536879, EBI-2801965;
CC O43482; Q9NYP9: MIS18A; NbExp=23; IntAct=EBI-536879, EBI-1104552;
CC O43482; Q6P0N0: MIS18BP1; NbExp=4; IntAct=EBI-536879, EBI-9870821;
CC O43482; Q8IVT2: MISP; NbExp=3; IntAct=EBI-536879, EBI-2555085;
CC O43482; Q6PF18: MORN3; NbExp=3; IntAct=EBI-536879, EBI-9675802;
CC O43482; Q9P2K5-2: MYEF2; NbExp=5; IntAct=EBI-536879, EBI-10318831;
CC O43482; Q8NFW9: MYRIP; NbExp=3; IntAct=EBI-536879, EBI-1759414;
CC O43482; O14561: NDUFAB1; NbExp=3; IntAct=EBI-536879, EBI-1246261;
CC O43482; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-536879, EBI-10172876;
CC O43482; P07196: NEFL; NbExp=3; IntAct=EBI-536879, EBI-475646;
CC O43482; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-536879, EBI-741048;
CC O43482; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-536879, EBI-2811583;
CC O43482; P37198: NUP62; NbExp=6; IntAct=EBI-536879, EBI-347978;
CC O43482; O43482: OIP5; NbExp=4; IntAct=EBI-536879, EBI-536879;
CC O43482; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-536879, EBI-10181968;
CC O43482; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-536879, EBI-11022007;
CC O43482; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-536879, EBI-14131832;
CC O43482; Q99697-2: PITX2; NbExp=3; IntAct=EBI-536879, EBI-12138495;
CC O43482; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-536879, EBI-2876622;
CC O43482; P52435: POLR2J; NbExp=3; IntAct=EBI-536879, EBI-394753;
CC O43482; P78424: POU6F2; NbExp=3; IntAct=EBI-536879, EBI-12029004;
CC O43482; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-536879, EBI-12000762;
CC O43482; P60891: PRPS1; NbExp=3; IntAct=EBI-536879, EBI-749195;
CC O43482; P0CG20: PRR35; NbExp=3; IntAct=EBI-536879, EBI-11986293;
CC O43482; P20618: PSMB1; NbExp=3; IntAct=EBI-536879, EBI-372273;
CC O43482; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-536879, EBI-958239;
CC O43482; Q9UJ41-4: RABGEF1; NbExp=3; IntAct=EBI-536879, EBI-14093916;
CC O43482; P04049: RAF1; NbExp=4; IntAct=EBI-536879, EBI-365996;
CC O43482; Q8N443: RIBC1; NbExp=3; IntAct=EBI-536879, EBI-10265323;
CC O43482; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-536879, EBI-11984663;
CC O43482; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-536879, EBI-6257312;
CC O43482; Q8WXG8: S100Z; NbExp=3; IntAct=EBI-536879, EBI-12198403;
CC O43482; Q7Z3H4: SAMD7; NbExp=3; IntAct=EBI-536879, EBI-12148649;
CC O43482; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-536879, EBI-3957636;
CC O43482; Q6ZSJ9: SHISA6; NbExp=6; IntAct=EBI-536879, EBI-12037847;
CC O43482; P12757: SKIL; NbExp=3; IntAct=EBI-536879, EBI-2902468;
CC O43482; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-536879, EBI-455078;
CC O43482; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-536879, EBI-9675976;
CC O43482; P14678-2: SNRPB; NbExp=3; IntAct=EBI-536879, EBI-372475;
CC O43482; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-536879, EBI-12288855;
CC O43482; O60504: SORBS3; NbExp=3; IntAct=EBI-536879, EBI-741237;
CC O43482; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-536879, EBI-12041693;
CC O43482; Q9BXF9: TEKT3; NbExp=5; IntAct=EBI-536879, EBI-8644516;
CC O43482; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-536879, EBI-12090309;
CC O43482; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-536879, EBI-11952651;
CC O43482; Q9UBB9: TFIP11; NbExp=6; IntAct=EBI-536879, EBI-1105213;
CC O43482; O60220: TIMM8A; NbExp=3; IntAct=EBI-536879, EBI-1049822;
CC O43482; O43711: TLX3; NbExp=3; IntAct=EBI-536879, EBI-3939165;
CC O43482; P06753: TPM3; NbExp=12; IntAct=EBI-536879, EBI-355607;
CC O43482; Q5VU62: TPM3; NbExp=5; IntAct=EBI-536879, EBI-10184033;
CC O43482; Q8N7U7-2: TPRX1; NbExp=5; IntAct=EBI-536879, EBI-14115717;
CC O43482; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-536879, EBI-492476;
CC O43482; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-536879, EBI-10259086;
CC O43482; Q15654: TRIP6; NbExp=4; IntAct=EBI-536879, EBI-742327;
CC O43482; Q12815: TROAP; NbExp=3; IntAct=EBI-536879, EBI-2349743;
CC O43482; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-536879, EBI-739895;
CC O43482; O75604: USP2; NbExp=3; IntAct=EBI-536879, EBI-743272;
CC O43482; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-536879, EBI-11975223;
CC O43482; O76024: WFS1; NbExp=3; IntAct=EBI-536879, EBI-720609;
CC O43482; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-536879, EBI-1051237;
CC O43482; Q15915: ZIC1; NbExp=5; IntAct=EBI-536879, EBI-11963196;
CC O43482; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-536879, EBI-740727;
CC O43482; Q8N720: ZNF655; NbExp=3; IntAct=EBI-536879, EBI-625509;
CC O43482; Q9Y649; NbExp=3; IntAct=EBI-536879, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome
CC {ECO:0000269|PubMed:17199038}. Chromosome, centromere
CC {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in
CC interphase cells, from late anaphase to the G1 phase. Not detected on
CC centromeres during earlier phases of mitosis. Associated with
CC chromatin.
CC -!- SIMILARITY: Belongs to the mis18 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01129}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF025441; AAC39561.1; ALT_INIT; mRNA.
DR EMBL; BC015050; AAH15050.1; -; mRNA.
DR CCDS; CCDS10074.1; -.
DR RefSeq; NP_001304789.1; NM_001317860.1.
DR RefSeq; NP_009211.1; NM_007280.1.
DR AlphaFoldDB; O43482; -.
DR SMR; O43482; -.
DR BioGRID; 116467; 212.
DR ComplexPortal; CPX-3272; Mis18 complex.
DR CORUM; O43482; -.
DR IntAct; O43482; 166.
DR MINT; O43482; -.
DR STRING; 9606.ENSP00000220514; -.
DR iPTMnet; O43482; -.
DR PhosphoSitePlus; O43482; -.
DR BioMuta; OIP5; -.
DR EPD; O43482; -.
DR jPOST; O43482; -.
DR MassIVE; O43482; -.
DR MaxQB; O43482; -.
DR PaxDb; O43482; -.
DR PeptideAtlas; O43482; -.
DR PRIDE; O43482; -.
DR ProteomicsDB; 48965; -.
DR Antibodypedia; 23263; 139 antibodies from 20 providers.
DR DNASU; 11339; -.
DR Ensembl; ENST00000220514.8; ENSP00000220514.3; ENSG00000104147.9.
DR GeneID; 11339; -.
DR KEGG; hsa:11339; -.
DR MANE-Select; ENST00000220514.8; ENSP00000220514.3; NM_007280.2; NP_009211.1.
DR UCSC; uc001znp.3; human.
DR CTD; 11339; -.
DR DisGeNET; 11339; -.
DR GeneCards; OIP5; -.
DR HGNC; HGNC:20300; OIP5.
DR HPA; ENSG00000104147; Tissue enhanced (bone marrow, skeletal muscle, testis).
DR MIM; 606020; gene.
DR neXtProt; NX_O43482; -.
DR OpenTargets; ENSG00000104147; -.
DR PharmGKB; PA134887641; -.
DR VEuPathDB; HostDB:ENSG00000104147; -.
DR eggNOG; ENOG502S5R3; Eukaryota.
DR GeneTree; ENSGT00940000154267; -.
DR InParanoid; O43482; -.
DR OMA; KEVTPDQ; -.
DR OrthoDB; 1253924at2759; -.
DR PhylomeDB; O43482; -.
DR TreeFam; TF330739; -.
DR PathwayCommons; O43482; -.
DR Reactome; R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR SignaLink; O43482; -.
DR BioGRID-ORCS; 11339; 605 hits in 1088 CRISPR screens.
DR ChiTaRS; OIP5; human.
DR GenomeRNAi; 11339; -.
DR Pharos; O43482; Tbio.
DR PRO; PR:O43482; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; O43482; protein.
DR Bgee; ENSG00000104147; Expressed in oocyte and 119 other tissues.
DR ExpressionAtlas; O43482; baseline and differential.
DR Genevisible; O43482; HS.
DR GO; GO:0015030; C:Cajal body; IDA:MGI.
DR GO; GO:0000785; C:chromatin; IDA:MGI.
DR GO; GO:0010369; C:chromocenter; IEA:Ensembl.
DR GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; NAS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR InterPro; IPR034752; Mis18.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51793; MIS18; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Metal-binding; Mitosis;
KW Nucleus; Phosphoprotein; Reference proteome; Zinc.
FT CHAIN 1..229
FT /note="Protein Mis18-beta"
FT /id="PRO_0000058038"
FT DOMAIN 75..174
FT /note="Mis18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 80
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 221
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MUTAGEN 77
FT /note="V->E: Abolishes interaction with MIS18A; when
FT associated with D-172."
FT /evidence="ECO:0000269|PubMed:26921242"
FT MUTAGEN 172
FT /note="Y->D: Abolishes interaction with MIS18A; when
FT associated with E-77."
FT /evidence="ECO:0000269|PubMed:26921242"
SQ SEQUENCE 229 AA; 24691 MW; 0EBD4006193A3106 CRC64;
MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL GPAGLGAEEP
AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS LGAVVFSRVT NNVVLEAPFL
VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS THAALAALRG HFCLSSDKMV CYLLKTKAIV
NASEMDIQNV PLSEKIAELK EKIVLTHNRL KSLMKILSEV TPDQSKPEN
