MS1_ARATH
ID MS1_ARATH Reviewed; 672 AA.
AC Q9FMS5; Q93V55;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=PHD finger protein MALE STERILITY 1;
GN Name=MS1; OrderedLocusNames=At5g22260; ORFNames=T6G21.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11696184; DOI=10.1046/j.1365-313x.2001.01125.x;
RA Wilson Z.A., Morroll S.M., Dawson J., Swarup R., Tighe P.J.;
RT "The Arabidopsis MALE STERILITY1 (MS1) gene is a transcriptional regulator
RT of male gametogenesis, with homology to the PHD-finger family of
RT transcription factors.";
RL Plant J. 28:27-39(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=7824655; DOI=10.1104/pp.106.3.863;
RA Hensel L.L., Nelson M.A., Richmond T.A., Bleecker A.B.;
RT "The fate of inflorescence meristems is controlled by developing fruits in
RT Arabidopsis.";
RL Plant Physiol. 106:863-876(1994).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=12461128; DOI=10.1093/pcp/pcf154;
RA Ito T., Shinozaki K.;
RT "The MALE STERILITY1 gene of Arabidopsis, encoding a nuclear protein with a
RT PHD-finger motif, is expressed in tapetal cells and is required for pollen
RT maturation.";
RL Plant Cell Physiol. 43:1285-1292(2002).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=16908508; DOI=10.1093/jxb/erl032;
RA Vizcay-Barrena G., Wilson Z.A.;
RT "Altered tapetal PCD and pollen wall development in the Arabidopsis ms1
RT mutant.";
RL J. Exp. Bot. 57:2709-2717(2006).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, AUTOREGULATION, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=18032629; DOI=10.1105/tpc.107.054981;
RA Yang C., Vizcay-Barrena G., Conner K., Wilson Z.A.;
RT "MALE STERILITY1 is required for tapetal development and pollen wall
RT biosynthesis.";
RL Plant Cell 19:3530-3548(2007).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLU-627; CYS-635;
RP HIS-640 AND CYS-643.
RX PubMed=18032630; DOI=10.1105/tpc.107.054536;
RA Ito T., Nagata N., Yoshiba Y., Ohme-Takagi M., Ma H., Shinozaki K.;
RT "Arabidopsis MALE STERILITY1 encodes a PHD-type transcription factor and
RT regulates pollen and tapetum development.";
RL Plant Cell 19:3549-3562(2007).
RN [9]
RP INDUCTION BY SDG2.
RX PubMed=21037105; DOI=10.1105/tpc.110.079962;
RA Berr A., McCallum E.J., Menard R., Meyer D., Fuchs J., Dong A., Shen W.H.;
RT "Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and is
RT crucial for both sporophyte and gametophyte development.";
RL Plant Cell 22:3232-3248(2010).
RN [10]
RP INDUCTION BY BRASSINOSTEROIDS AND BES1.
RX PubMed=20231470; DOI=10.1073/pnas.0912333107;
RA Ye Q., Zhu W., Li L., Zhang S., Yin Y., Ma H., Wang X.;
RT "Brassinosteroids control male fertility by regulating the expression of
RT key genes involved in Arabidopsis anther and pollen development.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:6100-6105(2010).
CC -!- FUNCTION: Transcriptional activator required for anther and post-
CC meiotic pollen development and maturation. Seems to regulate
CC inflorescence branching and floral development. May control tapetal
CC development by directly regulating tapetal programmed cell death (PCD)
CC and breakdown. Implicated in pollen cytosolic components and wall
CC development (e.g. exine and intine formation).
CC {ECO:0000269|PubMed:11696184, ECO:0000269|PubMed:12461128,
CC ECO:0000269|PubMed:16908508, ECO:0000269|PubMed:18032629,
CC ECO:0000269|PubMed:18032630, ECO:0000269|PubMed:7824655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12461128,
CC ECO:0000269|PubMed:18032629}.
CC -!- TISSUE SPECIFICITY: In closed flower buds, especially in anthers.
CC {ECO:0000269|PubMed:11696184}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in anthers from closed
CC buds, with expression in the tapetum at the stage before microspore
CC release from tetrads. {ECO:0000269|PubMed:11696184,
CC ECO:0000269|PubMed:12461128}.
CC -!- INDUCTION: Self down-regulation. Regulated by SDG2 via chromatin
CC methylation. Seems inducible by brassinosteroids via BES1.
CC {ECO:0000269|PubMed:18032629, ECO:0000269|PubMed:20231470,
CC ECO:0000269|PubMed:21037105}.
CC -!- DISRUPTION PHENOTYPE: No production of viable pollen. Degeneration of
CC pollen occurs soon after microspore release from the tetrads, at which
CC time the tapetum also appears abnormally vacuolated. Abnormal presence
CC of ultrastructural features of apoptosis (PCD) in microspores, but lack
CC of normal PCD in tapetum. Disturbed inflorescence branching and floral
CC development. Impaired cell wall modifications after primexine formation
CC within the callose wall, accompanied by reduced internal intine wall.
CC {ECO:0000269|PubMed:11696184, ECO:0000269|PubMed:12461128,
CC ECO:0000269|PubMed:16908508, ECO:0000269|PubMed:18032629,
CC ECO:0000269|PubMed:18032630, ECO:0000269|PubMed:7824655}.
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DR EMBL; AJ344209; CAC69663.1; -; Genomic_DNA.
DR EMBL; AJ344210; CAC69664.1; -; mRNA.
DR EMBL; AB007651; BAB08324.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93002.1; -; Genomic_DNA.
DR RefSeq; NP_197618.1; NM_122131.2.
DR AlphaFoldDB; Q9FMS5; -.
DR SMR; Q9FMS5; -.
DR STRING; 3702.AT5G22260.1; -.
DR iPTMnet; Q9FMS5; -.
DR PaxDb; Q9FMS5; -.
DR PRIDE; Q9FMS5; -.
DR EnsemblPlants; AT5G22260.1; AT5G22260.1; AT5G22260.
DR GeneID; 832286; -.
DR Gramene; AT5G22260.1; AT5G22260.1; AT5G22260.
DR KEGG; ath:AT5G22260; -.
DR Araport; AT5G22260; -.
DR TAIR; locus:2176317; AT5G22260.
DR eggNOG; KOG1844; Eukaryota.
DR HOGENOM; CLU_012141_0_0_1; -.
DR InParanoid; Q9FMS5; -.
DR OMA; EIYWGLR; -.
DR OrthoDB; 347301at2759; -.
DR PhylomeDB; Q9FMS5; -.
DR PRO; PR:Q9FMS5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048655; P:anther wall tapetum morphogenesis; IMP:TAIR.
DR GO; GO:0071367; P:cellular response to brassinosteroid stimulus; IEP:UniProtKB.
DR GO; GO:0055046; P:microgametogenesis; IMP:TAIR.
DR GO; GO:0009846; P:pollen germination; IMP:TAIR.
DR GO; GO:0010208; P:pollen wall assembly; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0022414; P:reproductive process; IMP:CACAO.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW Activator; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..672
FT /note="PHD finger protein MALE STERILITY 1"
FT /id="PRO_0000405993"
FT ZN_FING 614..664
FT /note="PHD-type"
FT MUTAGEN 627
FT /note="E->K: Normal fertility."
FT /evidence="ECO:0000269|PubMed:18032630"
FT MUTAGEN 635
FT /note="C->A: Impaired fertility."
FT /evidence="ECO:0000269|PubMed:18032630"
FT MUTAGEN 640
FT /note="H->N: Impaired fertility; when associated with G-
FT 643."
FT /evidence="ECO:0000269|PubMed:18032630"
FT MUTAGEN 643
FT /note="C->G: Impaired fertility; when associated with N-
FT 640."
FT /evidence="ECO:0000269|PubMed:18032630"
FT CONFLICT 412
FT /note="S -> G (in Ref. 1; CAC69663/CAC69664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 672 AA; 77004 MW; FEAC54A884B4D69E CRC64;
MANLIRTDHQ QHIPKKRKRG ESRVFRLKTF GESGHPAEMN ELSFRDNLAK LLEFGHFESS
GLMGSWSFQL EIQRNPNPLY VLLFVVEEPI EASLNLRCNH CQYVGWGNQM ICNKKYHFVI
PSKETMAAFL KLEGGGYAFP EKESFSHLVE LQGHVLHGFF HSNGFGHLLS LNGIETGSDL
TGHQVMDLWD RLCTGLKARK IGLNDASHKK GMELRLLHGV AKGEPWFGRW GYRFGSGTYG
VTQKIYEKAL ESVRNIPLCL LNHHLTSLNR ETPILLSKYQ SLSTEPLITL SDLFRFMLHL
HSRLPRDNYM SNSRNQIISI DSTNCRWSQK RIQMAIKVVI ESLKRVEYRW ISRQEVRDAA
RNYIGDTGLL DFVLKSLGNQ VVGNYLVRRS LNPVKKVLEY SLEDISNLLP SSNNELITLQ
NQNSMGKMAT NGHNKITRGQ VMKDMFYFYK HILMDYKGVL GPIGGILNQI GMASRAILDA
KYFIKEYHYI RDTSAKTLHL DRGEELGIFC TIAWKCHHHN NEIKVPPQEC IVVKKDATLS
EVYGEAERVF RDIYWELRDV VVESVVGGQI EITRVDEMAL NGNKGLVLEG NVGMMMNIEV
TKCYEDDDKK KDKRIECECG ATEEDGERMV CCDICEVWQH TRCVGVQHNE EVPRIFLCQS
CDQHLIPLSF LP
