MS2A_DROSE
ID MS2A_DROSE Reviewed; 255 AA.
AC P33736; B4I1L5; Q6RCC1; Q6RCC2; Q6RCC3; Q6RCC4; Q6RCC6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Accessory gland-specific peptide 26Aa;
DE AltName: Full=Male accessory gland secretory protein 355A;
DE Flags: Precursor;
GN Name=Acp26Aa; Synonyms=Mst26Aa, mst355a; ORFNames=GM17990;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1361475; DOI=10.1093/genetics/132.3.755;
RA Aguade M., Miyashita N., Langley C.H.;
RT "Polymorphism and divergence in the Mst26A male accessory gland gene region
RT in Drosophila.";
RL Genetics 132:755-770(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-255, AND VARIANTS LEU-25; ARG-33;
RP PHE-36; MET-37; ASN-38; ILE-39; PHE-117; VAL-207 AND TRP-244.
RC STRAIN=01, 11, 33, 34, 35, 7, 77 25, 81, Praslin, and Robertson;
RX PubMed=15238524; DOI=10.1534/genetics.103.020883;
RA Kern A.D., Jones C.D., Begun D.J.;
RT "Molecular population genetics of male accessory gland proteins in the
RT Drosophila simulans complex.";
RL Genetics 167:725-735(2004).
CC -!- FUNCTION: This protein is transferred from male to female's hemolymph
CC during mating, affecting egglaying and behavior after mating.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- TISSUE SPECIFICITY: Main cells of the accessory glands of males.
CC -!- PTM: It undergoes several cleavages as it is secreted and it is further
CC processed in the recipient female.
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DR EMBL; X72630; CAA51206.1; -; Genomic_DNA.
DR EMBL; CH480820; EDW54422.1; -; Genomic_DNA.
DR EMBL; AY505178; AAS99356.1; -; Genomic_DNA.
DR EMBL; AY505179; AAS99357.1; -; Genomic_DNA.
DR EMBL; AY505180; AAS99358.1; -; Genomic_DNA.
DR EMBL; AY505181; AAS99359.1; -; Genomic_DNA.
DR EMBL; AY505182; AAS99360.1; -; Genomic_DNA.
DR EMBL; AY505183; AAS99361.1; -; Genomic_DNA.
DR EMBL; AY505184; AAS99362.1; -; Genomic_DNA.
DR EMBL; AY505185; AAS99363.1; -; Genomic_DNA.
DR EMBL; AY505186; AAS99364.1; -; Genomic_DNA.
DR EMBL; AY505187; AAS99365.1; -; Genomic_DNA.
DR RefSeq; XP_002038004.1; XM_002037968.1.
DR AlphaFoldDB; P33736; -.
DR EnsemblMetazoa; FBtr0200975; FBpp0199467; FBgn0260790.
DR GeneID; 6613536; -.
DR KEGG; dse:6613536; -.
DR HOGENOM; CLU_1162203_0_0_1; -.
DR OMA; NTYRNKY; -.
DR PhylomeDB; P33736; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0007618; P:mating; IEA:InterPro.
DR GO; GO:2000130; P:positive regulation of octopamine signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0060279; P:positive regulation of ovulation; IEA:EnsemblMetazoa.
DR InterPro; IPR004315; Male_ac_gland_sc.
DR Pfam; PF03082; MAGSP; 1.
PE 2: Evidence at transcript level;
KW Behavior; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..255
FT /note="Accessory gland-specific peptide 26Aa"
FT /id="PRO_0000021756"
FT REGION 86..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 25
FT /note="Q -> L (in strain: 35)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 33
FT /note="K -> R (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 36
FT /note="S -> F (in strain: 77 25 and Praslin)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 37
FT /note="T -> M (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 38
FT /note="K -> N (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 39
FT /note="S -> I (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 117
FT /note="L -> F (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 207
FT /note="I -> V (in strain: 7)"
FT /evidence="ECO:0000269|PubMed:15238524"
FT VARIANT 244
FT /note="G -> W (in strain: 11)"
FT /evidence="ECO:0000269|PubMed:15238524"
SQ SEQUENCE 255 AA; 28345 MW; 960B3BFB4A984005 CRC64;
MNLILLCSQI LLLLFTVANC DGEHQLDSSM DLKSDSTKSA VLKNVAPKND ATQAEIAKDD
VALKSGKKGD YVMEIDVSDI PLDDYPINNS KSRKNSSTLP SQILTDKPNQ GSNQIALKAL
KHRLLMEQNN NLFLRNHSVS LMNEIEARKT DIIQARQLNI DLELELEALK RELSEMNAQN
ARKSTKSCKK RPSKDIASPV NQLQEVIVKN TYRNKYLTLL TQLAQKINYE IANVNNPATD
VPTGKSPSEG NPSTT
