MS300_DROME
ID MS300_DROME Reviewed; 12345 AA.
AC M9MRD1;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Muscle-specific protein 300 kDa {ECO:0000305};
DE AltName: Full=Nesprin-like protein Msp300 {ECO:0000305};
GN Name=Msp300 {ECO:0000312|FlyBase:FBgn0261836};
GN ORFNames=CG42768 {ECO:0000312|FlyBase:FBgn0261836};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH KLAR AND SLS, AND DOMAIN.
RX PubMed=22927463; DOI=10.1083/jcb.201204102;
RA Elhanany-Tamir H., Yu Y.V., Shnayder M., Jain A., Welte M., Volk T.;
RT "Organelle positioning in muscles requires cooperation between two KASH
RT proteins and microtubules.";
RL J. Cell Biol. 198:833-846(2012).
CC -!- FUNCTION: Component of the LINC (LInker of Nucleoskeleton and
CC Cytoskeleton) complex involved in the connection between the nuclear
CC lamina and the cytoskeleton (By similarity). Collaborates with Klar to
CC promote even spacing of the myonuclei at the periphery of striated
CC muscle fibers by mediating a tight association between a nuclear ring
CC structure of Msp300 and the plus ends of a unique astral MT network
CC (PubMed:22927463). In addition, is essential for anchoring nuclei,
CC mitochondria and endoplasmic reticulum (ER) structures to the Z-disks
CC (PubMed:22927463). {ECO:0000250|UniProtKB:Q8NF91,
CC ECO:0000269|PubMed:22927463}.
CC -!- SUBUNIT: Core component of LINC complexes which are composed of inner
CC nuclear membrane SUN domain-containing proteins coupled to outer
CC nuclear membrane KASH domain-containing nesprins (By similarity).
CC Interacts with klar; this interaction allows the anchoring of the
CC Msp300 nuclear ring structure to the nuclear envelope
CC (PubMed:22927463). Interacts with sls; this interaction mediates the
CC recruitment of Msp300 to the Z-disks (PubMed:22927463).
CC {ECO:0000250|UniProtKB:Q8NF91, ECO:0000269|PubMed:22927463}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:22927463}.
CC Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22927463}.
CC Note=The recruitment of Msp300 to the Z-disks is mediated by the
CC interaction with sls. {ECO:0000269|PubMed:22927463}.
CC -!- DOMAIN: Msp300 and Klar KASH domains cooperate to mediate the
CC connection between a nuclear ring structure of Msp300 and the plus ends
CC of a unique astral microtubule (MT) network.
CC {ECO:0000269|PubMed:22927463}.
CC -!- SIMILARITY: Belongs to the nesprin family. {ECO:0000305}.
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DR EMBL; AE014134; ADV36944.1; -; Genomic_DNA.
DR RefSeq; NP_001188694.1; NM_001201765.2.
DR SMR; M9MRD1; -.
DR IntAct; M9MRD1; 1.
DR PRIDE; M9MRD1; -.
DR DNASU; 3771968; -.
DR EnsemblMetazoa; FBtr0303385; FBpp0292447; FBgn0261836.
DR GeneID; 3771968; -.
DR CTD; 3771968; -.
DR FlyBase; FBgn0261836; Msp300.
DR VEuPathDB; VectorBase:FBgn0261836; -.
DR PhylomeDB; M9MRD1; -.
DR BioGRID-ORCS; 3771968; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Msp300; fly.
DR GenomeRNAi; 3771968; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0261836; Expressed in crop (Drosophila) and 33 other tissues.
DR ExpressionAtlas; M9MRD1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IDA:FlyBase.
DR GO; GO:0005640; C:nuclear outer membrane; IDA:FlyBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
DR GO; GO:0030018; C:Z disc; IDA:FlyBase.
DR GO; GO:0003779; F:actin binding; IDA:FlyBase.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IPI:FlyBase.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0016477; P:cell migration; IMP:FlyBase.
DR GO; GO:0007303; P:cytoplasmic transport, nurse cell to oocyte; IMP:FlyBase.
DR GO; GO:0051643; P:endoplasmic reticulum localization; IMP:FlyBase.
DR GO; GO:0008335; P:female germline ring canal stabilization; IMP:FlyBase.
DR GO; GO:0060361; P:flight; IMP:FlyBase.
DR GO; GO:0007523; P:larval visceral muscle development; IMP:FlyBase.
DR GO; GO:0040011; P:locomotion; IMP:FlyBase.
DR GO; GO:0007498; P:mesoderm development; NAS:FlyBase.
DR GO; GO:0034453; P:microtubule anchoring; IGI:FlyBase.
DR GO; GO:0051646; P:mitochondrion localization; IMP:FlyBase.
DR GO; GO:0007097; P:nuclear migration; IMP:FlyBase.
DR GO; GO:0051647; P:nucleus localization; IGI:FlyBase.
DR GO; GO:0006997; P:nucleus organization; IGI:FlyBase.
DR CDD; cd00014; CH; 2.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.10.418.10; -; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 8.
DR SMART; SM00033; CH; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 52.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS51049; KASH; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Coiled coil; Cytoplasm; Leucine-rich repeat; Membrane;
KW Nucleus; Reference proteome; Repeat; TPR repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..12345
FT /note="Muscle-specific protein 300 kDa"
FT /id="PRO_0000454910"
FT TOPO_DOM 1..12295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT TRANSMEM 12296..12316
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 12317..12345
FT /note="Perinuclear space"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT REPEAT 249..273
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT DOMAIN 630..737
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 777..882
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 823..847
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 919..952
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 1089..1112
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 1389..1411
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 1603..1636
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 1616..1642
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 1903..1935
FT /note="HAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 2087..2109
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT DOMAIN 2109..2233
FT /note="Calponin-homology (CH) 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 2558..2581
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 2663..2696
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 2728..2751
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 2935..2959
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 3030..3053
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 3110..3207
FT /note="Spectrin 1"
FT /evidence="ECO:0000255"
FT REPEAT 3346..3379
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 3370..3393
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 3437..3462
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 3530..3556
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 3539..3633
FT /note="Spectrin 2"
FT /evidence="ECO:0000255"
FT REPEAT 3611..3634
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 3629..3662
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 3706..3739
FT /note="HAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 3748..3771
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 4177..4273
FT /note="Spectrin 3"
FT /evidence="ECO:0000255"
FT REPEAT 4360..4393
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 4371..4403
FT /note="HAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 4611..4701
FT /note="Spectrin 4"
FT /evidence="ECO:0000255"
FT REPEAT 4654..4676
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 4742..4763
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 4799..4830
FT /note="HAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 4820..4919
FT /note="Spectrin 5"
FT /evidence="ECO:0000255"
FT REPEAT 4839..4863
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 4894..4926
FT /note="HAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 5266..5289
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 5333..5357
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 5645..5678
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REPEAT 5761..5784
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 5791..5895
FT /note="Spectrin 6"
FT /evidence="ECO:0000255"
FT REPEAT 5820..5843
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 5979..6002
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 6088..6120
FT /note="HAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 6321..6405
FT /note="Spectrin 7"
FT /evidence="ECO:0000255"
FT REPEAT 6363..6387
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 6424..6530
FT /note="Spectrin 8"
FT /evidence="ECO:0000255"
FT REPEAT 6522..6555
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 6531..6554
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 6560..6587
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 6660..6695
FT /note="TPR 9"
FT /evidence="ECO:0000255"
FT REPEAT 7004..7026
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT REPEAT 7161..7195
FT /note="TPR 10"
FT /evidence="ECO:0000255"
FT REPEAT 7219..7242
FT /note="LRR 28"
FT /evidence="ECO:0000255"
FT REPEAT 7300..7318
FT /note="LRR 29"
FT /evidence="ECO:0000255"
FT REPEAT 7319..7339
FT /note="LRR 30"
FT /evidence="ECO:0000255"
FT REPEAT 7340..7361
FT /note="LRR 31"
FT /evidence="ECO:0000255"
FT REPEAT 7524..7547
FT /note="LRR 32"
FT /evidence="ECO:0000255"
FT REPEAT 7644..7676
FT /note="HAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 7654..7687
FT /note="TPR 11"
FT /evidence="ECO:0000255"
FT REPEAT 7692..7714
FT /note="LRR 33"
FT /evidence="ECO:0000255"
FT REPEAT 7752..7777
FT /note="LRR 34"
FT /evidence="ECO:0000255"
FT REPEAT 7759..7792
FT /note="TPR 12"
FT /evidence="ECO:0000255"
FT REPEAT 7816..7840
FT /note="LRR 35"
FT /evidence="ECO:0000255"
FT REPEAT 7878..7911
FT /note="TPR 13"
FT /evidence="ECO:0000255"
FT REPEAT 8178..8201
FT /note="LRR 36"
FT /evidence="ECO:0000255"
FT REPEAT 8238..8264
FT /note="LRR 37"
FT /evidence="ECO:0000255"
FT REPEAT 8298..8321
FT /note="LRR 38"
FT /evidence="ECO:0000255"
FT REPEAT 8354..8377
FT /note="LRR 39"
FT /evidence="ECO:0000255"
FT REPEAT 8431..8464
FT /note="TPR 14"
FT /evidence="ECO:0000255"
FT REPEAT 8534..8557
FT /note="LRR 40"
FT /evidence="ECO:0000255"
FT REPEAT 9699..9721
FT /note="LRR 41"
FT /evidence="ECO:0000255"
FT REPEAT 9995..10019
FT /note="LRR 42"
FT /evidence="ECO:0000255"
FT REPEAT 10073..10096
FT /note="LRR 43"
FT /evidence="ECO:0000255"
FT REPEAT 10231..10264
FT /note="TPR 15"
FT /evidence="ECO:0000255"
FT REPEAT 10252..10276
FT /note="LRR 44"
FT /evidence="ECO:0000255"
FT REPEAT 10353..10376
FT /note="LRR 45"
FT /evidence="ECO:0000255"
FT REPEAT 10426..10458
FT /note="HAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 10512..10535
FT /note="LRR 46"
FT /evidence="ECO:0000255"
FT REPEAT 10570..10593
FT /note="LRR 47"
FT /evidence="ECO:0000255"
FT REPEAT 10644..10667
FT /note="LRR 48"
FT /evidence="ECO:0000255"
FT REPEAT 10854..10888
FT /note="TPR 16"
FT /evidence="ECO:0000255"
FT REPEAT 10855..10887
FT /note="HAT 9"
FT /evidence="ECO:0000255"
FT REPEAT 10907..10929
FT /note="LRR 49"
FT /evidence="ECO:0000255"
FT REPEAT 11021..11043
FT /note="LRR 50"
FT /evidence="ECO:0000255"
FT REPEAT 11070..11104
FT /note="HAT 10"
FT /evidence="ECO:0000255"
FT REPEAT 11072..11105
FT /note="TPR 17"
FT /evidence="ECO:0000255"
FT REPEAT 11197..11222
FT /note="LRR 51"
FT /evidence="ECO:0000255"
FT REPEAT 11342..11365
FT /note="LRR 52"
FT /evidence="ECO:0000255"
FT REPEAT 11398..11422
FT /note="LRR 53"
FT /evidence="ECO:0000255"
FT REPEAT 11670..11692
FT /note="LRR 54"
FT /evidence="ECO:0000255"
FT REPEAT 11697..11720
FT /note="LRR 55"
FT /evidence="ECO:0000255"
FT REPEAT 11744..11766
FT /note="LRR 56"
FT /evidence="ECO:0000255"
FT REPEAT 11804..11836
FT /note="HAT 11"
FT /evidence="ECO:0000255"
FT REPEAT 11959..11981
FT /note="LRR 57"
FT /evidence="ECO:0000255"
FT REPEAT 12198..12220
FT /note="LRR 58"
FT /evidence="ECO:0000255"
FT DOMAIN 12287..12345
FT /note="KASH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00385"
FT REPEAT 12301..12323
FT /note="LRR 59"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2699..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6631..6657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8583..8616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8966..9023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9131..9158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9361..9459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9502..9735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9769..9797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12253..12272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2894..2962
FT /evidence="ECO:0000255"
FT COILED 6356..6397
FT /evidence="ECO:0000255"
FT COILED 6454..6484
FT /evidence="ECO:0000255"
FT COILED 6567..6597
FT /evidence="ECO:0000255"
FT COILED 7419..7457
FT /evidence="ECO:0000255"
FT COILED 7799..7935
FT /evidence="ECO:0000255"
FT COILED 10072..10099
FT /evidence="ECO:0000255"
FT COILED 10172..10257
FT /evidence="ECO:0000255"
FT COILED 11016..11046
FT /evidence="ECO:0000255"
FT COILED 11220..11247
FT /evidence="ECO:0000255"
FT COILED 11281..11308
FT /evidence="ECO:0000255"
FT COILED 11655..11685
FT /evidence="ECO:0000255"
FT COILED 11776..11806
FT /evidence="ECO:0000255"
FT COMPBIAS 35..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2708..2724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8597..8612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8967..9015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9133..9147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9367..9381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9440..9454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9527..9621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9654..9684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9712..9735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12253..12268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 12345 AA; 1405148 MW; 7ADA518C19093708 CRC64;
MADSGGPGSK HMDPTTIDAG GGGAGAAGGD DVPPVPAVRR RRAHEQKSSR EQVLEEEKSQ
QLETSTVTRT YMKTITTSLT TSSSSNVEEF ILGEHAAGAA AAPSPNQQRL RQKVAQYEKV
WSDGSSPVKR PAEQSSDELR LTDDQDEYDA ENPFEIDVHE IERRLRQERQ RGLAEAEAAK
LAFQQVQLRH TTPPRRVEVT SDQVASPFNV TLRTTSRMSP GAEHGNVEEH LAPFNVTLRT
TRRTKKKEFK ELENFLEGER TVREVPSADG VRTIITSSMT SDGGYAEEKI YRHGEGYVSP
RDSPSWSRSS YSSERSSVTP PRSVDLTAGG RRILIKLEQE SELTEENQTR DETDLSFGRQ
EVAMATGNID ITVGGSNPRR RLYQQTTVQV GGGNRTSPQD STPQRPRDLD LAGTTKTMLT
STPIGTKEQP QTGPKTLVSP AATCQLRGSS TEEPRKIVSH KTITSTTTKS TSSSTSATSS
SSTSRKLIET SPVVVGKIAQ IRTGKSNASD NDIDIDNDSD TEGRPASSIV IVSTPTRPTT
PATASVSASA VTPSASISAT AAHALSGIGT FSKSLRQDYQ TLATQSGRSN ESPSDQEYQE
FQSTMASINY ARSNSQYDSH IKEKREEQER VQKKTFTNWI NSYLLKRVPP LRIDDLINDL
RDGTKLIALL EVLSGERLPV EKGRVLRRPH FLSNANTALQ FLASKRIKLV NINPADLVDG
RPPVVLGLIW TIILYFQIEE NSRNLEYLGH GIGGSVSSLD SVGNQKHGDL KAEKWKQGAR
KTLLNWVTNA LPKDSGVEVK DFGASWRDGV AFLALIDAIK ANLVNLAELK KTSNRQRLET
AFDVAESKLG IAKLLDAEDV DVPKPDEKSI MTYVAQFLHK YPEPKGASRD QSHVQQEADE
LRRFLVEKTT EYEPMVMMSS FPRDFGEYLL ARSEVDAHLA AYNRLKQLIE SQSGFLQVSR
QSWEEINELW QRLQYQMMYW LWLLDSELPG DFGTVGKWLA EAEKLLMDND IPNAMNEETA
AVISRKLEEH KLFFADLPRI LAMFDNAKRS PVAQQIPLEQ LRNMERRLQE VGPKAAERRI
RLKFLEHKCC LIAFLNLVEN KMRGWTGKYG HEEKVAQQLE QYKNFVSRNK IFQEFQKAFV
DMQQVVEEYK RDGNVPRKEI NDIDRFMYET EERWKRVSME LKCCQNSLEE VVNCWRSWNQ
LAPTCEEWLQ LAEQKVNQSE DERLDFFQDI PVWKDKFDAL ASSANYLIAS CEEPIAQQLR
QRHGALSERF ERLFANTKQY MHAGDIIRSR QEYKSGIEQL SRWLRGAESV LDQRQVLGNS
EQVKEYGQQL QQLASEIDDN EELFKTISRN FQSLIQDLSR DEVDKMMKLL KQEKESLVRI
RAQLPAKLHL FHQLQIQQES LEAGQKEIHQ WLSEAEQLLG THNLSGGRDA INEQLHKHKT
YFSRTVYYRS MLESKNKVFQ NLLKAVSSDD KIDTAPASQQ MQQLNERFNY VIQNAQQWEQ
RLDSAAGGWS NFKDNERVVS EWLTQAESML VEKHIESKTT IETQKYFFEQ VNDRWMNDLV
QSAQQLLTTL PAQEQPAVVH SVEQLQSRWK NVLSQAPLHL LKLEFRLDEN AFYQSLKDVE
KELQLEQQAL NRNEDVDSIL QRNQQFLLQQ DVVPRLERCL QNMQRLAQAH RQQQPGDISL
DQAYDNAKSQ WQLLSNKLGD MRQTLQQIPA QWQGYHLKFN DMVDWMNGVD QSLKNIVNEV
NTMEEFEKEK VVFQKICQDA DNKREDMKWL VKTLDSLLSY ATEDEANLEQ KKLEDLIARY
KNLIPTIEIT MVKTEVFSKC YTYRREVHEV VCLLSKVKDQ TANIPAPDSL DRVNRLIEEQ
QYAINQLDHQ RPHIMSMLQR GRDLIKDVHA PAFVNAEVKN LETGWNQAYT ETSDKLQALK
GTQAVWSEFV DQKNDIFSML QTAETELRSL TPLQTDPKNV SQDLKSKRDL NVQLQQASHQ
LLPKLHALKS ELAPLAAPDK RPILEKEVTE VEKMFFNTME HVKDRVGYLE DYSAKWNNYK
TRLAELQEWA NKVAPKNIEA LQSEDLTPEE RVVKVQAFKR ILGDRMKQLD LLAADASELA
PKEGNIAEAK RLKGEITKLQ EVLSAINRNV DHQAQAVQED LVNWQQFQAG LQQIKPAVEQ
SEVKVNNVVS KPISLEEAVA MQQNAQQFET QCQEQLDKLH GISNISHKML CKTNAPDELD
AMHSRWTAVH ENAKQASAKL EKLVANWKSF DADAAKLEDW VGQGEQQMSR RPAVLNTPHI
DKLEKELVKL KSFNNEISQQ QAKLVTLGQN ADQISLHLAP EGAAALKDRV NQMKGKLQKL
SEATRGHINE VSDAIISRQD FNAKLVNFSN WMEQLRNQVT QVEEINPERV ETSLHVIHAL
LQEHADKKPS FNAIYDEVKQ LALGATPEES NALNDAYTAL VVNYQNLETN MLQKKAALEK
WTELLGWKND TESHLNYLKH QLDKPEGPAA EELSKVIDEI DNLGQGIGYW KGQAKEIDEN
PAIQLRDALS RRPLIATQIV NDVENKLENL KLRSQSQQQQ IQQMTVRKDK FHALEHNFGQ
ALQENRAKLD EILRQHPTLN NIDQIIADLV ALNDALKYQA DLKNRIHDEG SLLMREDIAS
MPAIQESLLI MDKNYDSLQN EIADRIQKYN LISQALREYA DSKDKFSKEL KKAEDLYNAI
PQQPRDETEL HQASEKTRKT MEQLRKSKLS LDELERRGNN VGKLFSAIGE PIPQEVPQEV
TAAKQHWQDL HDKTAKNAHV YETEAVIWSQ IEDAKKDLLP WLSETNQGLC DAADNSIEIE
FGPMRLSKYR TELPSYQALK DSIVEKTNDL VKINKGAEIP ALSALNKLLS EQFAEVNNNA
DRLSAITTSF NDQEQELRRR SKEAGERVSK LREQLIKCDD MSGDNNKIME RLQQCRALRG
ELDNSGNEID NIKQKVDELR NLYPTFSESI IPKELNNVQK RYENVDLYAK KIESSLLQFL
KKFHADKVGM LKRIIATQRE KVAWCQPESS SDKYNLDVKK SSLQEVSKSI DDCKARHAET
LKSLEMLKAV ESPQNLAELT SDAELLRKDM QALQDSFDQI KGILDENVDL WSQYEQSNEQ
ISNWLRDVEG RVKAETSSQV NLSEVPQKLQ ELSILQQDVL AHEPIINNLE QTSQQLIEKN
PEARIGQFVT HLVQRYQAVS KALTSYIDKI RGAQLSNANF AKAAKDFNEW FGDAKIEFQE
LARMGSPGSS SATAQQLQTV KNYIKTFDNG QILLNNAVDI GEALYPVVSP DNRERIRADL
RQMREKFDYL RDEANAFMQQ VEGVLIQKTS IEESYTQVSH YLNESKAKVP TTDELYPTLA
TKKAALQNYK TQLQEITLHK NALKQLHDKA VTLCDDESER KTDESIQEYN TLSKKISDRI
TTVGNHVVKH EAYDQVLEKA QDWLNTIKSE AIDILNETTF EKEGAEEKLL VVENLLQHKP
EGDSIFDTCH KLLETVLTQT HPSGHPALLK GFEEPKQSWE DFMTLCQDSL VKLKQLCSKW
DEFDTIIEEL DNWMKNVEAV VKNQNLKSTA EAKNAHLKQL QDISKDIERR GAAINELMDQ
GREIEGETDL NLKLSRLNTR YQTLKNLCKE SIAKYVNYVK DHESFDKDFD SFKQNLQSSV
DELAKTNEIV GDQSVLQDQQ NKLREMSDKR ILDSTLFEGL IDRGEKLYGH TSPEGREIIR
QQLRALRTLW DNYTDDLNSA TQKIDQCLLQ FNEFSIAQDQ LTKWLKDVDK AMQSHTEPKT
TLQEKRAQLQ NHKLLHQEIT THNVLVDNVC DKAQILVDQI KDNSLNVYLT SIKQLFQSIV
QKSDEILHNL DDCVQKHNEL NNALSSAKTW ISNEKAKLLE CDDAYGEKAD IKRKIETLGQ
LAQNKPQAMK IISDIRDLFE KVKATTSEKG NEVLDKEIEE LETTMKSHFD DIEGIEGKQK
DVLAQWDKFE KALEELTKWC RSAEAVFREQ QLQSTLHEKV EQLEKYKIQR ELILQKEKEI
DAFGDAAHAL LNNCGADRLK TLTTQITNRY QLLQVLSKEV VNRWSNLVDD HQFYQDKYNE
VDLWLQPIES QMAKVLLDEP TQSSNILQVL LSEKEQAESL FAALNAAGEK ALPETSTQGR
EKIRKDLRDI RDRWDKLDEG IRNLEKRQEA QGVQLSSYQD ILNQTVNWLD QVEKLIHNEN
PASWTSAQEI RSKLYKYKAT NQDINSHKRI VEAVNEKAAA LLGSAAPANA DEISKAVAEV
NKRYDQVGQD CAKLVADLDG AFDVYQQFSE LQKAQQDYQK NLWDRLTGYS DYSGNKAALQ
ARLQKINEIQ DALPEGVAKL KSLEDHIEQQ ASNIPARSKE VMARDLANLH ADFEKFGASL
SDVKSGLENR LQQWNDYEIN LDRLITWLGE AENSLKNYNL KSSFEEKEEQ LNGFQSLAQN
LRQNEADFDK VKDDTSELVQ SSGETRIAVN VQQVSSRFQS IQATAKEILK KCEQAVQDHG
HFNDKYKQCA DWLANAQARY DDCCDLSTVA SRDDLLKKQV VIQELLAQQP TATQLLNSTV
ELGEKCYGST ATEGREAIRS QLDDLTFDQL FDNIAITARK IQDKIAKWSG FDEIADSLKS
WLDETENALP ADIELKTTLD EKRNKLQTYR DILNDINNHQ VELGNLQEIA ANLPEKTELV
DQIIKDISDR FGKLQKRAQN YVERYEGIVS AHQQYSKAVM DAQEFIDATL NTVHYWGDLD
LEQISLHTNL DRLKNLKASL ADEFPRVDQV RALGEKVIPG TVDVGQVNIK SQIDTTQQEW
ESLLTTISST IEAIEARLQH WSEYEQLRDQ CLAWIRDTDN NLHAIDLKED LPKKRAQLDA
LKALQGDVRA KELEVDNVTE KAQTLLKGPS SNRASGPELV TKYQQIFHKV KELNNRWQQY
VTSHEDFDNA ISDCSSWINE IKEKLDYCSD MSSMSPKELD KKLATIQDVI LLKDEGSARV
LKILEQAQHV LANTAPGGHE AINKELTDLQ DLWSGIALRI MDVKSNLDDS ITQWSGFLDQ
VQNVRKFNEW LDGQVKELSE HQTTMTEKRA QLDRVKSTEE KVRVEKIDVD ALKIQAKEMI
ASGQQSQAAF QAQKVLDTFD ELFAKTQKLL SHRQDQYRDH RLFKEAYDDL VSWIGRAREK
FPSLKQSSLS DKLAIENAVQ ATEALLNKQA QGELLVEHLV HTGEVVLAST SAQGQEIIRN
DIRALRDSFE GLFREINQQK ENLEVTMVQW RAYKEEYERL MEWLQQIDIL VKNHKLNLCP
NLPEKEKQVA DMKEVMSRLE KGKDDIDKFN ASAASLLKSH LDTYVNNQLR HLSSVYQVQV
NLAKDVLKKV ETNRDQHREY DANMKSAKDW IANAKATIQS AGEGAGSKEA LQRRLEQIQD
LIRNRELGQN LVHTAINNGE KIIRNTRSDG RDAINTEMKE LQTEWDRLVK KMSTAKVQLE
TNLLQWADYS SSYSQLQQWI TDREAKLQQA CEQKIVKSKR GQPGLSSGLS ERKANLRQTN
NIVQDIVSFE PMIQSVTSKA SVLQQGAPGT EISDKYENLT KQAKDLYEKQ KNTIESYQSL
IDAGNEFATW LRNAKERLSK CSEPTGDKQA LAEKTHQLKI LQGELPEGAQ KLKNALEQGE
IACRSAEPED CEIIEQEVAL LQEEFDAYRE ALNKAKDYLE VGIVKWSDYQ DQYTEALEWL
SKTEALVQSY NKLQDSLIQK KVVLEQFQGH LQTLFDWQKT LDDLNMKAQV LLETCSDTRI
SNAIMQLTTK YNALLTLAKE VMRRLEMHYQ EHQQHHSLYE ECQSWIEKTR EKLSECEQIP
GTLNEVQIKL NTVKNLRQGF ETGQNKLRYL LELKEKVIMN TEQNGAAKIQ EDTEALKQDF
DKLLVDLNDV RQKLANRLAQ LEEIFKLYKI LIEWLEDVEP SVKTSDEFLN DLSEKRAALE
KFRVIQRDIN GHNDIVEKIN QRLKEDNSLD LKDFQPGLTK FDDLQTQVNK IIESLENQVN
SHEKYKQAYN ELQDWLRRTR IEVEQCADCH GEKDQVESRL NRLGDIQSSS LEGKALLEAC
EELSQAVIAT SGSEGQDNVA QEIKHLTSEW ETLQTISRDA RSSLESCLAA WQTFLQKFNK
INLWIETMNK RVTKSQEGEN KTPEDLVNAK KLLEEVLAEK DNVEDLNDNC ELLMEQSACT
RIRDQTIETQ ANYTKLLTSA QGLVAKIEKN LSDHTEFLNY KKEMDAWIEK AQQVLDDCST
DGDAAIIAQK LDTVNSLASR LPEGQHLLAL VQDAYSKASN ITPEDKQEKL RELMTKVRED
WDALGLAVKQ KLSDLKQAQN RWNDFAANKD KLEKWLNETE TTLKVAPETK GELSEMKTLL
ERYKTLSNEL KLKGNELEQL QSEARDLGTE VDAVNRLQSR CDKLKNDCSA HITALEQEMF
DYNAYHQSLQ DVEKWLLQIS FQLMAHNSLF ISNREQTQEQ IKQHEALLVE IQKYQTNLDD
LNAKGQAQIK RYESSTPAIR PTVESQLKNI QDSYNSLLQT SVQIKNRLLE SLAKFQEYED
TLDSIMRNLE TYEPIIQTEL DAPATSLELA QNQLRCAQEM QNKLNNEKSR LAAAVQACEA
ATASISRPSS PLETAMQAIP ERELIVRAKL EDLLDQKPPP KTRSSTGGVS TDDDKDEADV
EIQVELSDVN EALLDPIAHE RVKNYRRIVR LNSAHVGKLN ELVAKVQSHL GGLTASVSEL
EQQQKQRAEL QDWVKKQQSS VSDWMMRPCK LRPEAAQQEL VSMNDLLNSI GDKRSQLMLE
MTGSLGDEDT DLDDNIDKLE SELMDAIAKK QAGQNVIDGY RQGMADVQNW FDTLIKRMDV
LDRGSGLNCA QKMAAINEIK NEYELQGHPK IQELKGKAAQ VAEVISNLDG QQVEEQMKSL
DRRFADLGKR IDRKSQLLDV TNKGVEGAKG EIDQLQNWVK QQIEELQAPK PLGYTPKDAE
ARQQKIKSLM KDAEAKQSLA DVLEKRVANM QQELEPVEYS QLESALRNLN TENRNLSGVL
KAELDRALEA SKARKSLEND LDKARQWLKT KISEVRKLPV YHPLTSAEIE KKIQENRKYD
DDAKQFNDSV LTDVQRQAAN IMKDCDDADK AALQQILDEI AADYQTLKDE SSKRGKSLDD
LLQGRKAFED SMKNMGDWLN EMETATEGEL RTTSLPVLEE QLAHYKKLLS DAENKGGLIN
DVSEQGKSIL PTLSNADKLK LNDDIKNMKD RYGRIKNTID DRVNALGDHI KKYKDAKSRL
AECSQFLGNI QQKLRELNRP IGSRIEDVQD LLGAYEGILK ELKDSKSKMG DMQMDDLPEL
QSILAQQDDM IKLIEDQLAH LRQLLLLREQ FIALINEIIA FIMKYTDVII DIENSPDSLE
DKINKYDDVI VKIQECEGVL ASANDKGQKI ASEGNAADKN SITEQLQSLK NQLQNLRKAV
ESQRQKHQLQ LESHKKMAAE LSEILDWLHS HEGAAKSRPL LDRDPESVER ELQKHQSLSQ
DIESYLNKFN KINDGVKTEI GMPSSLLEML SEGRSLVASL PHELEEREKY LKNNRDSRLE
YMQLVAKFND WVHEAELRLQ NSQHGIDYEH LVQDLDEHKI FFGNEAPIRN LVHKQIQEAA
DKIWSSLNNY EQSELSAELA QFQTKLTNTL ANAKTQQSEL EKEAERWREY QQSIDRVKAT
IERTKFVDEP VQNLAGLHFN IQKLSHAIGN VQSQNSDLTL VNQQAQSLIR QADARNRQLI
EQDNAGLNRS WQDLVRSLEQ RRDNLQQLAE HWDGFENSLH AWEKALGRLE DKFRNVDPTV
RSRRHLEDTK NAIQELREES NQLKSSHKEI EALSKSILTF LGEVHKPSAE AIQAKVDKLV
EQQAKLNDTL RDKEQQVSKD LEEIEQVFRR ISQLQDKLNA LHEQLQSVHV YDEHIAQTEQ
LLITLNSQVQ QAAEESKLLV AQTTAHYQAK QNQLPSDIAQ EFTALELLAE RVQVTMETKE
KDFKRAKTVR TEYVDGVDEV QRWLLQAEVQ VQERSLTPTQ MKELLQRINH EITAIYERFT
LVKTNGQLII ENCRNSEEKT LVQTTIDQLA ASLAQVRGWL DEKKQAVGDS LDAWTRFMNL
YQIVMSWASE KRNFIDQTIE LRTLPEARNK LNDYVTSVKS IKPIVKHLSE MDKELEHIGQ
VTTVGDLKDK LQEAEDAKIS VEAVLLERNS LLQEACEEWD QCERKIKDIR SWHEKTKQGL
DSSQQQKKPL RDQLGFCEKT LADINVQKTK LRLSIEKLEV HFRNGMGGDP RLSENVDDLV
RVLDGLGELV KAKSQSLEQT LAQIDVYQQQ MQSLRQRIIQ EEQQLRLVMA PTYLPHDRER
ALAEQQDLIT QELDELLQSL SSVEDGIANM NQSSLDGMLH GLKLIQSNLE VHERDAIELK
NQAKKLPTDP ATERLLNDTV DRIDLLLRRT QQGITMIANA MHGQKKRQQE IDEYQQHLLE
LEQWIIEVSA ELASFEPTSD SSTDEQVLKS QVERSQQLLR TLKDRQQSME DLVEQTRQLQ
SHPDVSPLAD TLMEQLQSII TILREQVTVA TKRIFTIEKR IVDLRKAKSE EAQRQRVLAD
SLIKPPTEAP ASPEAHESIE SNENTIDSSS MPEEEIKPTG VYVETQTSLS LQQPPVQVVT
TTTVEAQTSF KEPAVETAEV ALQTQKERSP TENIMVTQTV HHGQETIQID TTRNKDVPDE
PEDVQIEARY HQRPKGDVDR ATELILKNVP QAFETTFVEP DETTTEVIVG PDGTKHIVLK
KVTRTRQQVV QQQQISSIET ISDSDGNIEV HSTGQINLEN VHTTDTKADP EEGSVHTVIT
QQTRGAVVDS TQPEGVILQE FETEPTIETY EEVIAPGSQA QLIPMQPGDV QTQGTIRAVV
QQVTRKVIRK TRKIIKRVVI IDGKEHITEE VVEEPEEVEI TEEETAPHIN VNIVRTVDGK
VVSEEEFQRM MQEPGVLIEE VATDLQKPTA EPQQEVFDIE STQVTTTTRT TTATTQEQEQ
PEQQTQPTTT ETTKEAPVEL PAPQVDVEQP VVVATTSPVH VPTADVVEPK DSSPTSTTAA
VVDVEAVVED INEIWPLEHH LKPTNIDFSQ HVEELAAPAA VTAETEASMP VEEIWPTSPE
TGNSLTLEQY EFEPQSPHEE STKSDLVKPQ ETEPQVVAET KPEGITTGSI TITKTTTTIT
SSTEVPEETL VQNVPADEQQ PPANKIKTDI QSFLEAEQTL AAALKEQSST PTGASVAEDV
QTQPEEIVLE ERTVEISTIK TEENQQEPVI VEEVKSLPVE PEPVEPELEE VAIAIVEQTE
EKPEEPVIEK QPASGPIDLR AATQLFISGE AAASTAPQKT FQISAPSLED NGAGVLKVVL
GKESTNEEDT AAPTTGKVSM TIIETAAAPA ADAKRRRKKK KRRDTKHEEE LEQEQETEPE
PVAAVKEPEV SSDVPVSPED SPRDTVRHES IVEISPDSDL SSIEIDTKVK IVEDAVVSSP
SESPRTPMVE LVIPTEVVEL ALVEDEEQQT TPRIPSPTEK SEVEQDIKSV QTSPQHQPKL
DETAVQTSLE VQPDNQENES QTLIVEITET EAQTTPRSEE QSVAVEISTT EIQTDVSGQP
AETVEISSQT TVTTTIEKEL QTTPKDSPRA PEAGSSDVVE SLVQDLVKDM TTDLPVRTSE
QSTVTETTTT TETHVQTTTP EPREQTEVIK PETAHEETST VELVQFADGE MQTTPPGDQQ
PASLDDSSLT ATSISVSEPY ELEVKTTVAI PADSDTSVAE PTVYEYTQTM QLPKQEKKSK
KDKKKKQKNV PEVEQQLPED QQISVTVEIA PELLSESGIV VSTNQQIEDV PHVTPVVDTP
IESEEVETPK AQRVQLQITK TTVYDEYPDL PVHITEQNKV LIASQQSKRS GAGPTSSAVT
IEEVGSPTEE LVVPITPGPD NLSGEPHNIW FSATTSVDKT PIELSQALIM SESLQHYPGQ
QKLTQEPILI STKEAIGDRI KQLKQASPQQ ATPLSNVLHL ATLSEQIKEL PTEQRILEVN
EGLKDLDVAI KNGDKTVIQT TVITVIEKVS TWLETIEYRV YLIRQNSNEG PSEEKLDNYN
QLNDELSTIK QNVVQLERQL SKAEPEPQLL QCVDSLKEHV DAVEQVTQQN QVQDSNDLDK
WHNFEVLLYN VSSVLADLQQ SYDLLINQEY PLSAKLAQLD ELEQQHEAAQ QQLAHLCQNA
RAFQRDFPGK KMPQDVHNAF ETSKNIANNI QAERERVLQL QSLAEEYEQT LKEFTKITVL
ADKLVESPIV SSSLEQLNNE VQKQRKFFVN LSHCRAMLES LEENIDSETR EKHSELHKEL
YNRATSLLDK ASERSSKLVQ AASRWTVLEK GMRDELQWLQ VAQQRVPDLS AVTSADYDQY
TTLYQSLSND ISHHYVKMTQ LSGIANKLQL LVQAPNLVEE TNEALIVLLK LREEVALYLH
RLLVFKEIWV QYEQQTDKLE AFVREAEQEL RNIQIPSQPT HQPIEHMRQF WEIKARFELH
NNVRTDTGLS FEKSLQVIPL ADEMLQRQFH AQLEDRWQAV AQAIELIQHN IVECLSSEDV
PADEKLKMVE RELQEIYLTM TSMKGVIKNE EELCLYIERV QVLRTRVGFI GNELGRIGLQ
EPAIEPEKVG ELFSLSHKIS TQIAEELEGA SVLRDQLQAI QEGISNQRKH QAKISVILDE
CEAAERQGAD VLEKAVADCQ AAGEELVISW QEIMRIRQML HTLPMRLKMS VSPVKLERDI
SQLQDDHAFL ESKCTNIMAI LRSRLAVWLR YERQLELVHG SVQETDFMME LIRVHGQVDY
ERLRKATERL EGLAGDLHNR EQLIDELKGA AKPLIESCDV QIVEQIESAV QEAVVAWNDT
SENLQQLRTR YQRAVELWDK YRNASAAVKN SIDQQMDAVK SLEQPLDALQ HAKVCQDNLT
TQNDRILELR DIVAKIAADV GLDASALMQG ELDALGQRLA ECKDAITTLA NVAETQDKER
KELDKEVTLA KAYFNNVQQD ISREAPQNPK ESEEQLAALR AHLQTLARTE EQLRQLKERH
QNSEVAPSVA SSDDDGILEV LALWQKIFQD TFQEYHRLST RLARSQNSSE ALRLWRQYLQ
HVQSFLSCAI PEDYSSLREQ QQLCAIHQNL LISQQSVLSE TPLESELSEQ YKALTNLHNE
TLSRIMQRNG ELERRVSGWN AYRQQLAALL DWLRQREAER NALQLRYIHL KRVPHLKHRL
DAMIQQLDQG EQQSKALQEQ QQELARHCDD ALATAMRMEQ ASIGQRISNL RAALKTWQGF
LQRVTQLSES YEQRVNQLQQ EFGAAQKLLD ANSESLPTQP AAIEQLLGSL RAQRVQLGAQ
VSALESLTVT QEELKECISP HDMKTIRQRN WLLWQQHADL DYQLANLINS IEERLSLLSN
YQIRYDRISQ WLQRLEQRVE KDADVTAMTN PEQAAKQLEQ QVNSELQLRD KEREWLLSTS
RELLTLYSEP EVRSQVQQQS DSLIDRWQRL KYLAKQKATK IGELKMTLLR LEERIALIRA
WLFEVESQLD KPLNFESYTP NVIEAKLKEH EQIQRSIEHH SSNVGEVLNL VEMLLNDADS
WRTQVNTSGL AASAQNLEQR WKNVCSQSAE RKARILTIWN LLQQLIKLTA EHKNWLGKQE
SQIAGFERDQ KSHSKHKLEE RQMELRAKLE ELESQSVNLR QLEQIYAKLA MSAGVEPENI
QKLTLPTKVM VSMWRQLTPR CHALLDAIDK DAKLMREFNN AQLEATNSLN AIQKALEQLP
SAENQQTSKA EPKAVLQRLE SLEKKLQDAQ QHVQQADNLA QEAKTRTKQQ PQLKQLLELV
SAYTTLWQTV QTRIVTLKTT WLTRAAQAAA SLPVSEAANA AVQVNTLSQR KLRQAQQMQR
ETSITAKDAY IMELQTAITE CQNNLDELQR TVVDKTRKPG PQKIAKLLGN AQSSTELVKH
LSHLLLTECK ADDQAAEVDT VAELTLRFDT LQSQWKARQQ HDQNASEVGR LTCPLCTQRN
WQQIDNDLWR LEQWLQFAES TQKAQSAPPS NIELLEDVTQ DHREFLLDLE SHKSIISSLN
VVGDHLATHT LDTEKARQLR SRLEADNERW NNVCINATKW QGLLQTALMG NSEFHQTIGE
LVEWLQRTEQ NIKASEPVDL TEERSVLETK FKKFKDLRAE LERCEPRVVS LQDAADQLLR
SVEGSEQQSQ HTYERTLSRL TDLRLRLQSL RRLSGIYIVK LGAVLGYEGD NLGVPLHMLS
SELLDNTTLS TSSMQAAAPN TENANNTDGG DAVDGDVINT TVLARGARFL GRVARASLPI
QALMLLLLGV ATLVPHGEDY TCMFSNTFAR SLEPMLSYPH GPPPT
