MS4A3_MOUSE
ID MS4A3_MOUSE Reviewed; 213 AA.
AC Q920C4; Q99MX6;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Membrane-spanning 4-domains subfamily A member 3;
DE AltName: Full=Hematopoietic-specific transmembrane protein 4;
DE Short=HTm4;
GN Name=Ms4a3; Synonyms=Htm4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=11488981; DOI=10.1046/j.1440-1711.2001.01017.x;
RA Hulett M.D., Pagler E., Hornby J.R.;
RT "Cloning and characterization of a mouse homologue of the human
RT haematopoietic cell-specific four-transmembrane gene HTm4.";
RL Immunol. Cell Biol. 79:345-349(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-124.
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA Liang Y., Tedder T.F.;
RT "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT family: sixteen new MS4A family members expressed in human and mouse.";
RL Genomics 72:119-127(2001).
CC -!- FUNCTION: Hematopoietic modulator for the G1-S cell cycle transition.
CC Modulates the level of phosphorylation of cyclin-dependent kinase 2
CC (CDK2) through its direct binding to cyclin-dependent kinase inhibitor
CC 3 (CDKN3/KAP) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes
CC through its binding to CDKN3; this interaction facilitates dissociation
CC of cyclin A from CDKN3-CDK2 complexes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at low levels only in specific immune
CC tissues, such as, spleen, bone marrow and peripheral blood leukocytes.
CC -!- DOMAIN: The C-terminal region is required for binding to CDKN3-CDK2
CC complexes and the modulation of CDKN3 activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR EMBL; AF321128; AAL16955.1; -; mRNA.
DR EMBL; AK036464; BAC29440.1; -; mRNA.
DR EMBL; AF280401; AAK37993.1; -; mRNA.
DR CCDS; CCDS29605.1; -.
DR RefSeq; NP_573509.1; NM_133246.5.
DR AlphaFoldDB; Q920C4; -.
DR SMR; Q920C4; -.
DR STRING; 10090.ENSMUSP00000108608; -.
DR PhosphoSitePlus; Q920C4; -.
DR PaxDb; Q920C4; -.
DR PRIDE; Q920C4; -.
DR Antibodypedia; 14413; 169 antibodies from 23 providers.
DR DNASU; 170813; -.
DR Ensembl; ENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
DR Ensembl; ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681.
DR GeneID; 170813; -.
DR KEGG; mmu:170813; -.
DR UCSC; uc008gsp.2; mouse.
DR CTD; 932; -.
DR MGI; MGI:2158468; Ms4a3.
DR VEuPathDB; HostDB:ENSMUSG00000024681; -.
DR eggNOG; ENOG502T41X; Eukaryota.
DR GeneTree; ENSGT00940000162383; -.
DR HOGENOM; CLU_091032_6_0_1; -.
DR InParanoid; Q920C4; -.
DR OMA; QRHFFFF; -.
DR OrthoDB; 1239340at2759; -.
DR PhylomeDB; Q920C4; -.
DR TreeFam; TF335157; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 170813; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ms4a3; mouse.
DR PRO; PR:Q920C4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q920C4; protein.
DR Bgee; ENSMUSG00000024681; Expressed in femorotibial joint and 40 other tissues.
DR ExpressionAtlas; Q920C4; baseline and differential.
DR Genevisible; Q920C4; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; TAS:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030417; MS4A.
DR InterPro; IPR030419; MS4A3.
DR PANTHER; PTHR23320; PTHR23320; 1.
DR PANTHER; PTHR23320:SF74; PTHR23320:SF74; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..213
FT /note="Membrane-spanning 4-domains subfamily A member 3"
FT /id="PRO_0000158633"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..148
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 189..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 213 AA; 22872 MW; A3C0A60F602C2BB0 CRC64;
MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ HVSHHFRHFF
FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG INIASTTIAF VGTVFLSVHL
AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV SLMLILTLLE LSVTISISAM WCLGNVCGLR
EAITSPPNSV ESGILPEGSD SENLNTQPQA SEE
