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MS4A5_HUMAN
ID   MS4A5_HUMAN             Reviewed;         200 AA.
AC   Q9H3V2; Q9BZH1;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 5;
DE   AltName: Full=CD20 antigen-like 2;
DE   AltName: Full=Testis-expressed transmembrane protein 4;
GN   Name=MS4A5; Synonyms=CD20L2, TETM4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11245982; DOI=10.1016/s0378-1119(00)00598-9;
RA   Ishibashi K., Suzuki M., Sasaki S., Imai M.;
RT   "Identification of a new multigene four-transmembrane family (MS4A) related
RT   to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.";
RL   Gene 264:87-93(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA   Liang Y., Tedder T.F.;
RT   "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT   family: sixteen new MS4A family members expressed in human and mouse.";
RL   Genomics 72:119-127(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11162526; DOI=10.1006/bbrc.2000.4088;
RA   Hulett M.D., Pagler E., Hornby J.R., Hogarth P.M., Eyre H.J., Baker E.,
RA   Crawford J., Sutherland G.R., Ohms S.J., Parish C.R.;
RT   "Isolation, tissue distribution, and chromosomal localization of a novel
RT   testis-specific human four-transmembrane gene related to CD20 and Fc-
RT   epsilon-RI-beta.";
RL   Biochem. Biophys. Res. Commun. 280:374-379(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] ARG-123.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in signal transduction as a component of a
CC       multimeric receptor complex.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed at high level in the testis. Detected
CC       also in the pancreas, heart and in the brain.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; AB013103; BAB18739.1; -; mRNA.
DR   EMBL; AF237907; AAK37416.1; -; mRNA.
DR   EMBL; AF321127; AAK01641.1; -; mRNA.
DR   EMBL; BC029884; AAH29884.1; -; mRNA.
DR   CCDS; CCDS7987.1; -.
DR   PIR; JC7585; JC7585.
DR   RefSeq; NP_076434.2; NM_023945.2.
DR   AlphaFoldDB; Q9H3V2; -.
DR   SMR; Q9H3V2; -.
DR   BioGRID; 122120; 1.
DR   IntAct; Q9H3V2; 1.
DR   STRING; 9606.ENSP00000300190; -.
DR   BioMuta; MS4A5; -.
DR   DMDM; 29611830; -.
DR   PaxDb; Q9H3V2; -.
DR   PeptideAtlas; Q9H3V2; -.
DR   PRIDE; Q9H3V2; -.
DR   Antibodypedia; 27921; 77 antibodies from 14 providers.
DR   DNASU; 64232; -.
DR   Ensembl; ENST00000300190.7; ENSP00000300190.2; ENSG00000166930.7.
DR   GeneID; 64232; -.
DR   KEGG; hsa:64232; -.
DR   MANE-Select; ENST00000300190.7; ENSP00000300190.2; NM_023945.3; NP_076434.2.
DR   UCSC; uc001npo.3; human.
DR   CTD; 64232; -.
DR   DisGeNET; 64232; -.
DR   GeneCards; MS4A5; -.
DR   HGNC; HGNC:13374; MS4A5.
DR   HPA; ENSG00000166930; Tissue enriched (testis).
DR   MIM; 606499; gene.
DR   neXtProt; NX_Q9H3V2; -.
DR   OpenTargets; ENSG00000166930; -.
DR   PharmGKB; PA31118; -.
DR   VEuPathDB; HostDB:ENSG00000166930; -.
DR   eggNOG; ENOG502RR0Z; Eukaryota.
DR   GeneTree; ENSGT00940000162612; -.
DR   HOGENOM; CLU_091032_5_0_1; -.
DR   InParanoid; Q9H3V2; -.
DR   OMA; LFGVMNF; -.
DR   OrthoDB; 1389739at2759; -.
DR   PhylomeDB; Q9H3V2; -.
DR   TreeFam; TF335157; -.
DR   PathwayCommons; Q9H3V2; -.
DR   SignaLink; Q9H3V2; -.
DR   BioGRID-ORCS; 64232; 16 hits in 1048 CRISPR screens.
DR   GenomeRNAi; 64232; -.
DR   Pharos; Q9H3V2; Tdark.
DR   PRO; PR:Q9H3V2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H3V2; protein.
DR   Bgee; ENSG00000166930; Expressed in sperm and 91 other tissues.
DR   ExpressionAtlas; Q9H3V2; baseline and differential.
DR   Genevisible; Q9H3V2; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   InterPro; IPR030426; MS4A5.
DR   PANTHER; PTHR23320; PTHR23320; 1.
DR   PANTHER; PTHR23320:SF54; PTHR23320:SF54; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..200
FT                   /note="Membrane-spanning 4-domains subfamily A member 5"
FT                   /id="PRO_0000158637"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..120
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         123
FT                   /note="L -> R (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036402"
FT   CONFLICT        163
FT                   /note="F -> L (in Ref. 3; AAK01641)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   200 AA;  22283 MW;  F9282E5D15BC5514 CRC64;
     MDSSTAHSPV FLVFPPEITA SEYESTELSA TTFSTQSPLQ KLFARKMKIL GTIQILFGIM
     TFSFGVIFLF TLLKPYPRFP FIFLSGYPFW GSVLFINSGA FLIAVKRKTT ETLIILSRIM
     NFLSALGAIA GIILLTFGFI LDQNYICGYS HQNSQCKAVT VLFLGILITL MTFSIIELFI
     SLPFSILGCH SEDCDCEQCC
 
 
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