MS57C_DROME
ID MS57C_DROME Reviewed; 76 AA.
AC Q9V3J3; Q24392; Q3HKR0;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Accessory gland-specific peptide 57Dc;
DE AltName: Full=45 kDa cAMP-dependent phosphoprotein;
DE AltName: Full=Male accessory gland secretory protein 57Dc;
DE AltName: Full=Pp45;
DE Flags: Precursor;
GN Name=Mst57Dc; ORFNames=CG4986;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-40, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND PHOSPHORYLATION.
RC TISSUE=Male accessory gland;
RX PubMed=10451922; DOI=10.1016/s0965-1748(99)00046-6;
RA Cho K.S., Lim J.H., Won D.H., Gye M.C., Chung K.W., Lee C.C.;
RT "A 45-kDa cAMP-dependent phosphoprotein which is related to the product of
RT Mst57Dc in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 29:701-710(1999).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R; TISSUE=Male accessory gland;
RX PubMed=7711745; DOI=10.1016/0965-1748(94)00034-f;
RA Simmerl E., Schaefer M., Schaefer U.;
RT "Structure and regulation of a gene cluster for male accessory gland
RT transcripts in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 25:127-137(1995).
RN [3] {ECO:0000312|EMBL:ABA71704.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S {ECO:0000312|EMBL:ABA71704.1};
RX PubMed=15944345; DOI=10.1534/genetics.105.043844;
RA Mueller J.L., Ravi Ram K., McGraw L.A., Bloch Qazi M.C., Siggia E.D.,
RA Clark A.G., Aquadro C.F., Wolfner M.F.;
RT "Cross-species comparison of Drosophila male accessory gland protein
RT genes.";
RL Genetics 171:131-143(2005).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Transferred from male to female during mating and may affect
CC egglaying and behavior after mating.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10451922}.
CC -!- TISSUE SPECIFICITY: Lumen fluid of male accessory glands, becomes
CC seminal fluid. {ECO:0000269|PubMed:10451922,
CC ECO:0000269|PubMed:7711745}.
CC -!- DEVELOPMENTAL STAGE: Accumulates after eclosion and gradually increases
CC during sexual maturation. In males, levels decline immediately after
CC mating and recover progressively. {ECO:0000269|PubMed:10451922}.
CC -!- PTM: cAMP-dependent phosphorylation. {ECO:0000269|PubMed:10451922}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD33884.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA83927.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF142325; AAD33884.1; ALT_INIT; mRNA.
DR EMBL; Z33647; CAA83927.1; ALT_FRAME; Genomic_DNA.
DR EMBL; DQ231598; ABA71704.1; -; mRNA.
DR EMBL; AE014297; AAF56513.1; -; Genomic_DNA.
DR RefSeq; NP_524498.2; NM_079774.4.
DR AlphaFoldDB; Q9V3J3; -.
DR STRING; 7227.FBpp0084290; -.
DR PaxDb; Q9V3J3; -.
DR PRIDE; Q9V3J3; -.
DR EnsemblMetazoa; FBtr0339163; FBpp0308307; FBgn0011670.
DR GeneID; 43121; -.
DR KEGG; dme:Dmel_CG4986; -.
DR CTD; 43121; -.
DR FlyBase; FBgn0011670; Mst57Dc.
DR VEuPathDB; VectorBase:FBgn0011670; -.
DR HOGENOM; CLU_180286_0_0_1; -.
DR OMA; HNMLRCL; -.
DR PhylomeDB; Q9V3J3; -.
DR BioGRID-ORCS; 43121; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43121; -.
DR PRO; PR:Q9V3J3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011670; Expressed in male reproductive gland and 10 other tissues.
DR Genevisible; Q9V3J3; DM.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0018991; P:oviposition; NAS:UniProtKB.
DR GO; GO:0045924; P:regulation of female receptivity; NAS:UniProtKB.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
PE 1: Evidence at protein level;
KW Behavior; Direct protein sequencing; Phosphoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..76
FT /note="Accessory gland-specific peptide 57Dc"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021764"
SQ SEQUENCE 76 AA; 8452 MW; 0DB0BBAD5423B7BC CRC64;
MHGTHFLILL LLCGVLGSNG VTPDIKNVAK AERNMHNMLR CLKKNEPIVK SRILTLPPNC
NQYVSAVVET WKPEGV
