MSA1_SCHPO
ID MSA1_SCHPO Reviewed; 533 AA.
AC Q10277; Q9US63;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Multicopy suppressor of sporulation protein msa1;
GN Name=msa1; ORFNames=SPAC13G7.13c, SPAC6C3.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=15166138; DOI=10.1534/genetics.167.1.77;
RA Jeong H.T., Ozoe F., Tanaka K., Nakagawa T., Matsuda H., Kawamukai M.;
RT "A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces
RT pombe.";
RL Genetics 167:77-91(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 210-384, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: Negative regulator of sexual differentiation. Acts by
CC repressing the transcription of meiosis-inducing, ste11-regulated
CC genes. {ECO:0000269|PubMed:15166138}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10759889}.
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DR EMBL; CU329670; CAA93601.1; -; Genomic_DNA.
DR EMBL; AB028018; BAA87322.1; -; Genomic_DNA.
DR PIR; T39025; T39025.
DR RefSeq; NP_593715.2; NM_001019146.2.
DR AlphaFoldDB; Q10277; -.
DR BioGRID; 279307; 71.
DR STRING; 4896.SPAC13G7.13c.1; -.
DR iPTMnet; Q10277; -.
DR MaxQB; Q10277; -.
DR PaxDb; Q10277; -.
DR PRIDE; Q10277; -.
DR EnsemblFungi; SPAC13G7.13c.1; SPAC13G7.13c.1:pep; SPAC13G7.13c.
DR GeneID; 2542861; -.
DR KEGG; spo:SPAC13G7.13c; -.
DR PomBase; SPAC13G7.13c; msa1.
DR VEuPathDB; FungiDB:SPAC13G7.13c; -.
DR eggNOG; ENOG502QUGB; Eukaryota.
DR HOGENOM; CLU_511061_0_0_1; -.
DR InParanoid; Q10277; -.
DR OMA; HLDSKNC; -.
DR PRO; PR:Q10277; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; NAS:PomBase.
DR GO; GO:0031138; P:negative regulation of conjugation with cellular fusion; IMP:PomBase.
DR CDD; cd12453; RRM1_RIM4_like; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034352; Rim4_RRM1.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Cytoplasm; Reference proteome; Repeat; Repressor; RNA-binding;
KW Transcription; Transcription regulation.
FT CHAIN 1..533
FT /note="Multicopy suppressor of sporulation protein msa1"
FT /id="PRO_0000081648"
FT DOMAIN 79..158
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 365..441
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 30..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 59118 MW; A2A8A1633A0EC572 CRC64;
MVVSSPSVSL LHSPVEKLSA QLEKTTLLQD IPPGSLSEND NSTTFIKPPL ETASSSTPIP
SSSSSGVLNP SSVRGKPVAC LFVASLNSSR SEEELTATVK DYFQQWGPLL HVKVLKDWLQ
RPYSFVQFQN TDDASKALSE AQNTILDGRH IRIERAKVNR TIRISSAPHQ PYITKKDIDN
LLEPYGEVED VTEIPDQSAF LVRFVYRDEA IAAYTALKHS AWPVLWAENV TYQNGHYKKK
GSSPFSPPNA HSRRRKSQGK DQSNTPVIKA PAPIPFSVSS DPPSTMGRSN SAVQSPSYFA
HSLVNSTEFS TPNESLSSLP SILPSIPSLE SGKAELPTDG SFEQPGYPMN PSMMFAAMPP
PIDPYSIFVG QLDPVNCTHY LLVDLFSKYG KVIDCKIIHQ SKKPAFAFLR FDSQQAAYAA
VCGKTRSPHQ KKPLRVEFRQ LRPMQQFSPQ YQYPSYPYPM FPAPFSPPRN AMMPIPAPMD
QFSTFHQSMA TLPPGAVPTS IPQSYYPIYS PEMAMPQSYS PMYYTHNPPM DGN
