MSA2_PLAF7
ID MSA2_PLAF7 Reviewed; 272 AA.
AC P50498; Q9TY97;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Merozoite surface antigen 2;
DE Short=MSA-2;
DE AltName: Full=45 kDa merozoite surface antigen;
DE Flags: Precursor;
GN Name=MSA2; ORFNames=PFB0300c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2181307; DOI=10.1016/0166-6851(90)90061-p;
RA Smythe J.A., Peterson M.G., Coppel R.L., Saul A.J., Kemp D.J., Anders R.F.;
RT "Structural diversity in the 45-kilodalton merozoite surface antigen of
RT Plasmodium falciparum.";
RL Mol. Biochem. Parasitol. 39:227-234(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=9804551; DOI=10.1126/science.282.5391.1126;
RA Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L.,
RA Koonin E.V., Shallom S.J., Mason T., Yu K., Fujii C., Pederson J., Shen K.,
RA Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S.L.,
RA Zhou L., Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M.,
RA Adams M.D., Venter J.C., Hoffman S.L.;
RT "Chromosome 2 sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Science 282:1126-1132(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- FUNCTION: May play a role in the merozoite attachment to the
CC erythrocyte.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- DEVELOPMENTAL STAGE: During the trophozoite and schizont stages.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M28891; AAA29686.1; -; Genomic_DNA.
DR EMBL; AE001362; AAC71849.1; -; Genomic_DNA.
DR PIR; G71618; G71618.
DR RefSeq; XP_001349578.1; XM_001349542.1.
DR PDB; 2MU8; NMR; -; A=21-40.
DR PDB; 4QY8; X-ray; 1.35 A; Q=33-49.
DR PDB; 5TBD; X-ray; 2.20 A; C/H/I/L=233-240.
DR PDBsum; 2MU8; -.
DR PDBsum; 4QY8; -.
DR PDBsum; 5TBD; -.
DR AlphaFoldDB; P50498; -.
DR BMRB; P50498; -.
DR SMR; P50498; -.
DR BioGRID; 1207980; 13.
DR IntAct; P50498; 10.
DR STRING; 5833.PFB0300c; -.
DR PRIDE; P50498; -.
DR ABCD; P50498; 2 sequenced antibodies.
DR EnsemblProtists; CZT98080; CZT98080; PF3D7_0206800.
DR GeneID; 812660; -.
DR KEGG; pfa:PF3D7_0206800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0206800; -.
DR HOGENOM; CLU_1024782_0_0_1; -.
DR OMA; CINAITE; -.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:GeneDB.
DR GO; GO:0016021; C:integral component of membrane; IDA:GeneDB.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:GeneDB.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR DisProt; DP02299; -.
DR InterPro; IPR001136; MSA_2.
DR Pfam; PF00985; MSA_2; 1.
DR PIRSF; PIRSF003575; MSA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Malaria; Membrane; Merozoite; Repeat; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..246
FT /note="Merozoite surface antigen 2"
FT /id="PRO_0000024584"
FT PROPEP 247..272
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000024585"
FT REGION 44..198
FT /note="Polymorphic region"
FT REGION 45..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 246
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 245
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="S -> T (in Ref. 1; AAA29686)"
FT /evidence="ECO:0000305"
FT TURN 27..30
FT /evidence="ECO:0007829|PDB:2MU8"
FT TURN 35..37
FT /evidence="ECO:0007829|PDB:4QY8"
FT TURN 234..237
FT /evidence="ECO:0007829|PDB:5TBD"
SQ SEQUENCE 272 AA; 27957 MW; C7DE9172FD4B3B6F CRC64;
MKVIKTLSII NFFIFVTFNI KNESKYSNTF INNAYNMSIR RSMAESKPST GAGGSAGGSA
GGSAGGSAGG SAGGSAGSGD GNGADAEGSS STPATTTTTK TTTTTTTTND AEASTSTSSE
NPNHKNAETN PKGKGEVQEP NQANKETQNN SNVQQDSQTK SNVPPTQDAD TKSPTAQPEQ
AENSAPTAEQ TESPELQSAP ENKGTGQHGH MHGSRNNHPQ NTSDSQKECT DGNKENCGAA
TSLLNNSSNI ASINKFVVLI SATLVLSFAI FI
