MSA2_PLAFF
ID MSA2_PLAFF Reviewed; 264 AA.
AC P19599; Q6LAK6;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Merozoite surface antigen 2;
DE Short=MSA-2;
DE AltName: Full=AG513;
DE AltName: Full=Merozoite 45 kDa surface antigen;
DE Flags: Precursor;
GN Name=MSA2;
OS Plasmodium falciparum (isolate FC27 / Papua New Guinea).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5837;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3293051; DOI=10.1073/pnas.85.14.5195;
RA Smythe J.A., Coppel R.L., Brown G.V., Ramasamy R., Kemp D.J., Anders R.F.;
RT "Identification of two integral membrane proteins of Plasmodium
RT falciparum.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:5195-5199(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SH3, SH4, SH5, SH6, SH7, and SH8;
RX PubMed=9764340; DOI=10.1016/s0035-9203(98)90758-1;
RA Bhattacharya P.R.;
RT "Plasmodium falciparum: genetic polymorphism of the merozoite surface
RT antigen 2 gene of strains from India.";
RL Trans. R. Soc. Trop. Med. Hyg. 92:225-226(1998).
CC -!- FUNCTION: May play a role in the merozoite attachment to the
CC erythrocyte.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- DEVELOPMENTAL STAGE: During the trophozoite and schizont stages.
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DR EMBL; J03828; AAA29627.1; ALT_SEQ; mRNA.
DR EMBL; Y12644; CAA73191.1; -; Genomic_DNA.
DR EMBL; Y12645; CAA73192.1; -; Genomic_DNA.
DR EMBL; Y12646; CAA73193.1; -; Genomic_DNA.
DR EMBL; Y12647; CAA73194.1; -; Genomic_DNA.
DR EMBL; Y12648; CAA73195.1; -; Genomic_DNA.
DR EMBL; Y12649; CAA73196.1; -; Genomic_DNA.
DR PIR; A31818; A31818.
DR AlphaFoldDB; P19599; -.
DR BMRB; P19599; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR DisProt; DP01067; -.
DR InterPro; IPR001136; MSA_2.
DR Pfam; PF00985; MSA_2; 1.
DR PIRSF; PIRSF003575; MSA_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Malaria; Membrane;
KW Merozoite; Repeat; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..238
FT /note="Merozoite surface antigen 2"
FT /id="PRO_0000024592"
FT PROPEP 239..264
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000024593"
FT REPEAT 60..91
FT /note="1"
FT REPEAT 92..123
FT /note="2"
FT REGION 44..190
FT /note="Polymorphic region"
FT REGION 46..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..123
FT /note="2 X 32 AA perfects repeats"
FT COMPBIAS 46..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 238
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 264 AA; 27890 MW; 66DEF3B8357FEF3D CRC64;
MKVIKTLSII NFFIFVTFNI KNESKYSNTF INNAYNMSIR RSMANEGSNT NSVGANAPNA
DTIASGSQRS TNSASTSTTN NGESQTTTPT AADTIASGSQ RSTNSASTST TNNGESQTTT
PTAADTPTAT ESISPSPPIT TTESSKFWQC TNKTDGKGEE SEKQNELNES TEEGPKAPQE
PQTAENENPA APENKGTGQH GHMHGSRNNH PQNTSDSQKE CTDGNKENCG AATSLLSNSS
NIASINKFVV LISATLVLSF AIFI
