ID   MSA2_PLAFG              Reviewed;         287 AA.
AC   P19260;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Merozoite surface antigen 2, allelic form 2;
DE            Short=MSA-2;
DE   AltName: Full=Membrane protein PF7;
DE   Flags: Precursor;
GN   Name=MSA2;
OS   Plasmodium falciparum (isolate FCR-3 / Gambia).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5838;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1696728; DOI=10.1073/pnas.87.16.6363;
RA   Elliott J.F., Albrecht G.R., Gilladoga A., Handunnetti S.M., Neequaye J.,
RA   Lallinger G., Minjas J.N., Howard R.J.;
RT   "Genes for Plasmodium falciparum surface antigens cloned by expression in
RT   COS cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:6363-6367(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1990294; DOI=10.1128/mcb.11.2.963-971.1991;
RA   Fenton B., Clark J.T., Khan C.M.A., Robinson J.V., Walliker D., Ridley R.,
RA   Scaife J.G., McBride J.S.;
RT   "Structural and antigenic polymorphism of the 35- to 48-kilodalton
RT   merozoite surface antigen (MSA-2) of the malaria parasite Plasmodium
RT   falciparum.";
RL   Mol. Cell. Biol. 11:963-971(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2090943; DOI=10.1016/0166-6851(90)90146-d;
RA   Thomas A.W., Carr D.A., Carter J.M., Lyon J.A.;
RT   "Sequence comparison of allelic forms of the Plasmodium falciparum
RT   merozoite surface antigen MSA2.";
RL   Mol. Biochem. Parasitol. 43:211-220(1990).
RN   [4]
RP   GPI-ANCHOR AT ASN-261.
RX   PubMed=11104799; DOI=10.1084/jem.192.11.1563;
RA   Naik R.S., Branch O.H., Woods A.S., Vijaykumar M., Perkins D.J.,
RA   Nahlen B.L., Lal A.A., Cotter R.J., Costello C.E., Ockenhouse C.F.,
RA   Davidson E.A., Gowda D.C.;
RT   "Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular
RT   characterization and naturally elicited antibody response that may provide
RT   immunity to malaria pathogenesis.";
RL   J. Exp. Med. 192:1563-1576(2000).
CC   -!- FUNCTION: May play a role in the merozoite attachment to the
CC       erythrocyte.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- DEVELOPMENTAL STAGE: During the trophozoite and schizont stages.
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DR   EMBL; M28890; AAA29650.1; -; Genomic_DNA.
DR   EMBL; X53832; CAA37829.1; -; Genomic_DNA.
DR   EMBL; M60188; AAA29688.1; -; Genomic_DNA.
DR   PIR; B39615; B39615.
DR   AlphaFoldDB; P19260; -.
DR   BMRB; P19260; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR001136; MSA_2.
DR   Pfam; PF00985; MSA_2; 1.
DR   PIRSF; PIRSF003575; MSA_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Malaria; Membrane;
KW   Merozoite; Repeat; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..261
FT                   /note="Merozoite surface antigen 2, allelic form 2"
FT                   /id="PRO_0000024594"
FT   PROPEP          262..287
FT                   /note="Removed in mature form"
FT                   /id="PRO_0000024595"
FT   REGION          42..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..213
FT                   /note="Polymorphic region"
FT   COMPBIAS        42..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           261
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000269|PubMed:11104799"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        236
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  28555 MW;  3968B90DAA917AF8 CRC64;
     MKVIKTLSII NFFIFVTFNI KNESKYSNTF INNAYNMSIR RSMTESNPPT GASGSAGGSA
     GGSAGGSAGG SAGGSAGGSA GGSAGGSAGG SAGGSAGGSA GGSAGSGDGN GANPGADAER
     SPSTPATTTT TTTTNDAEAS TSTSSENPNH NNAETNQANK ETQNNSNVQQ DSQTKSNVPP
     TQDADTKSPT AQPEQAENSA PTAEQTESPE LQSAPENKGT GQHGHMHGSR NNHPQNTSDS
     QKECTDGNKE NCGAATSLLN NSSNIASINK FVVLISATLV LSFAIFI