ID   MSA_STAA3               Reviewed;         133 AA.
AC   Q2FH37;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Protein msa;
DE   AltName: Full=Modulator of SarA;
GN   Name=msa; OrderedLocusNames=SAUSA300_1294;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Accessory element involved in the expression of sarA and
CC       several virulence factors. Modulates SarA production and/or function in
CC       a strain-dependent manner. Affects the transcription of the accessory
CC       gene regulator (agr) and genes encoding virulence factors including
CC       alpha toxin (hla) and protein A (spa) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CP000255; ABD20553.1; -; Genomic_DNA.
DR   RefSeq; WP_000876201.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FH37; -.
DR   SMR; Q2FH37; -.
DR   EnsemblBacteria; ABD20553; ABD20553; SAUSA300_1294.
DR   KEGG; saa:SAUSA300_1294; -.
DR   HOGENOM; CLU_157294_0_0_9; -.
DR   OMA; YNVHLMA; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="Protein msa"
FT                   /id="PRO_0000253056"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15657 MW;  7733CA6C85E6A7B8 CRC64;
     MKYLILSLVA NLLVFGVLSA IGLNINILAA MMIVLVIPIM ISGILFFKTN IDKTYIFFNI
     IFIDFYYYIY NVHLMTLPKF NNYIKAEMME LEDIDVLITS KDFGFDEILF YTLYLLLILI
     VLYYLKKQVK HKI