ID   MSA_STAA8               Reviewed;         133 AA.
AC   Q2FYN3;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Protein msa;
DE   AltName: Full=Modulator of SarA;
GN   Name=msa; OrderedLocusNames=SAOUHSC_01402;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=16946251; DOI=10.1099/mic.0.29071-0;
RA   Sambanthamoorthy K., Smeltzer M.S., Elasri M.O.;
RT   "Identification and characterization of msa (SA1233), a gene involved in
RT   expression of SarA and several virulence factors in Staphylococcus
RT   aureus.";
RL   Microbiology 152:2559-2572(2006).
CC   -!- FUNCTION: Accessory element involved in the expression of sarA and
CC       several virulence factors. Modulates SarA production and/or function in
CC       a strain-dependent manner. Affects the transcription of the accessory
CC       gene regulator (agr) and genes encoding virulence factors including
CC       alpha toxin (hla) and protein A (spa). {ECO:0000269|PubMed:16946251}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CP000253; ABD30496.1; -; Genomic_DNA.
DR   RefSeq; WP_000876201.1; NZ_LS483365.1.
DR   RefSeq; YP_499929.1; NC_007795.1.
DR   AlphaFoldDB; Q2FYN3; -.
DR   SMR; Q2FYN3; -.
DR   STRING; 1280.SAXN108_1418; -.
DR   EnsemblBacteria; ABD30496; ABD30496; SAOUHSC_01402.
DR   GeneID; 3920692; -.
DR   KEGG; sao:SAOUHSC_01402; -.
DR   PATRIC; fig|93061.5.peg.1283; -.
DR   HOGENOM; CLU_157294_0_0_9; -.
DR   OMA; YNVHLMA; -.
DR   PRO; PR:Q2FYN3; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="Protein msa"
FT                   /id="PRO_0000253055"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15657 MW;  7733CA6C85E6A7B8 CRC64;
     MKYLILSLVA NLLVFGVLSA IGLNINILAA MMIVLVIPIM ISGILFFKTN IDKTYIFFNI
     IFIDFYYYIY NVHLMTLPKF NNYIKAEMME LEDIDVLITS KDFGFDEILF YTLYLLLILI
     VLYYLKKQVK HKI