ID   MSA_STAAS               Reviewed;         133 AA.
AC   Q6G9G0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein msa;
DE   AltName: Full=Modulator of SarA;
GN   Name=msa; OrderedLocusNames=SAS1342;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Accessory element involved in the expression of sarA and
CC       several virulence factors. Modulates SarA production and/or function in
CC       a strain-dependent manner. Affects the transcription of the accessory
CC       gene regulator (agr) and genes encoding virulence factors including
CC       alpha toxin (hla) and protein A (spa) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BX571857; CAG43118.1; -; Genomic_DNA.
DR   RefSeq; WP_000876201.1; NC_002953.3.
DR   AlphaFoldDB; Q6G9G0; -.
DR   SMR; Q6G9G0; -.
DR   KEGG; sas:SAS1342; -.
DR   HOGENOM; CLU_157294_0_0_9; -.
DR   OMA; YNVHLMA; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="Protein msa"
FT                   /id="PRO_0000253062"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15657 MW;  7733CA6C85E6A7B8 CRC64;
     MKYLILSLVA NLLVFGVLSA IGLNINILAA MMIVLVIPIM ISGILFFKTN IDKTYIFFNI
     IFIDFYYYIY NVHLMTLPKF NNYIKAEMME LEDIDVLITS KDFGFDEILF YTLYLLLILI
     VLYYLKKQVK HKI