ID   MSA_STAAW               Reviewed;         133 AA.
AC   Q7A0X4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Protein msa;
DE   AltName: Full=Modulator of SarA;
GN   Name=msa; OrderedLocusNames=MW1289;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Accessory element involved in the expression of sarA and
CC       several virulence factors. Modulates SarA production and/or function in
CC       a strain-dependent manner. Affects the transcription of the accessory
CC       gene regulator (agr) and genes encoding virulence factors including
CC       alpha toxin (hla) and protein A (spa) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BA000033; BAB95154.1; -; Genomic_DNA.
DR   RefSeq; WP_000876201.1; NC_003923.1.
DR   AlphaFoldDB; Q7A0X4; -.
DR   SMR; Q7A0X4; -.
DR   EnsemblBacteria; BAB95154; BAB95154; BAB95154.
DR   KEGG; sam:MW1289; -.
DR   HOGENOM; CLU_157294_0_0_9; -.
DR   OMA; YNVHLMA; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="Protein msa"
FT                   /id="PRO_0000253063"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15657 MW;  7733CA6C85E6A7B8 CRC64;
     MKYLILSLVA NLLVFGVLSA IGLNINILAA MMIVLVIPIM ISGILFFKTN IDKTYIFFNI
     IFIDFYYYIY NVHLMTLPKF NNYIKAEMME LEDIDVLITS KDFGFDEILF YTLYLLLILI
     VLYYLKKQVK HKI