MSC6_YEAST
ID MSC6_YEAST Reviewed; 692 AA.
AC Q08818; D6W349;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Meiotic sister-chromatid recombination protein 6, mitochondrial;
DE Flags: Precursor;
GN Name=MSC6; OrderedLocusNames=YOR354C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=10511544; DOI=10.1093/genetics/153.2.621;
RA Thompson D.A., Stahl F.W.;
RT "Genetic control of recombination partner preference in yeast meiosis.
RT Isolation and characterization of mutants elevated for meiotic unequal
RT sister-chromatid recombination.";
RL Genetics 153:621-641(1999).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
CC -!- FUNCTION: May be involved in the control of meiotic sister-chromatid
CC recombination. {ECO:0000269|PubMed:10511544}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 7250 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z75262; CAA99683.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11115.1; -; Genomic_DNA.
DR PIR; S67266; S67266.
DR RefSeq; NP_014999.1; NM_001183774.1.
DR AlphaFoldDB; Q08818; -.
DR BioGRID; 34739; 219.
DR DIP; DIP-4057N; -.
DR STRING; 4932.YOR354C; -.
DR MaxQB; Q08818; -.
DR PaxDb; Q08818; -.
DR PRIDE; Q08818; -.
DR TopDownProteomics; Q08818; -.
DR EnsemblFungi; YOR354C_mRNA; YOR354C; YOR354C.
DR GeneID; 854536; -.
DR KEGG; sce:YOR354C; -.
DR SGD; S000005881; MSC6.
DR VEuPathDB; FungiDB:YOR354C; -.
DR eggNOG; ENOG502QW5R; Eukaryota.
DR HOGENOM; CLU_398067_0_0_1; -.
DR InParanoid; Q08818; -.
DR OMA; WVKYLET; -.
DR BioCyc; YEAST:G3O-33825-MON; -.
DR PRO; PR:Q08818; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08818; protein.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0003729; F:mRNA binding; HDA:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
PE 1: Evidence at protein level;
KW DNA recombination; Meiosis; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 31..692
FT /note="Meiotic sister-chromatid recombination protein 6,
FT mitochondrial"
FT /id="PRO_0000042820"
SQ SEQUENCE 692 AA; 79947 MW; 23C58EB31249DA31 CRC64;
MLSHNALRAF DCSKVIISRR CLTSSTSIYQ QSSVHLQETD DGHSGNREKH VSPFERVQNL
AADLKNELKA PDSDINEVFN DFKDKIESLK QKLRNPSPME RSHLLANFSS DLLQELSYRS
KNMTLDPYQV LNTLCQYKLA RSQHFTIVLK YLLYNQSPQD VIALWVKYLE TISENPVILL
QNSSSRAHMQ NIAITTIAYL SLPENTVDIN ILYKILQIDR KMGQVLPFNM IRRMLSTEFS
SLERRDVIIK NLNTLYYQYT VQDSDHFLSQ IENAPRWIDL RDLYGQYNKL EGEKNVEIIS
KFMDKFIDLD KPDQVVTIYN QYSKVFPNST SLKDCLLRAV SHLRAKSSKE KLDRILAVWN
SVIKPGDNIK NTSYATLVNA LTDSGNFNHL KEFWEEELPK KFKKDPIVKE AFLLALCQTS
PLKYDQVKGE LAETVKTKKL FNKVLLLMLD DEKVSEEQFN TFYYNHYPSD GVLPPTLDTL
SIKMYANYKF QAEDTRPQFD LLQSVSINPT DYEKVEKITK AFISVCPTVE PIRQLYKQLG
THLNARNYAD FISAEFNKPD GTVAEAKNLF SDFLSYQKTR KRNVDNTPLN ALLLGFCDKL
YKSKHSEYVP YIEKYYNLAK DSSIRVSNLA VSKILFNLAT FARNTQQLSD KEVAFINQFM
RDLGTNEGFR PNPKDIQILK ECDGITVPEK LT
