MSCL_FUSNN
ID MSCL_FUSNN Reviewed; 142 AA.
AC Q8RFE0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Large-conductance mechanosensitive channel {ECO:0000255|HAMAP-Rule:MF_00115};
GN Name=mscL {ECO:0000255|HAMAP-Rule:MF_00115}; OrderedLocusNames=FN0766;
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX NCBI_TaxID=190304;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC 2640 / LMG 13131 / VPI 4355;
RX PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- FUNCTION: Channel that opens in response to stretch forces in the
CC membrane lipid bilayer. May participate in the regulation of osmotic
CC pressure changes within the cell. {ECO:0000255|HAMAP-Rule:MF_00115}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000255|HAMAP-Rule:MF_00115}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00115}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00115}.
CC -!- SIMILARITY: Belongs to the MscL family. {ECO:0000255|HAMAP-
CC Rule:MF_00115}.
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DR EMBL; AE009951; AAL94962.1; -; Genomic_DNA.
DR RefSeq; NP_603663.1; NC_003454.1.
DR AlphaFoldDB; Q8RFE0; -.
DR STRING; 190304.FN0766; -.
DR EnsemblBacteria; AAL94962; AAL94962; FN0766.
DR KEGG; fnu:FN0766; -.
DR PATRIC; fig|190304.8.peg.1329; -.
DR eggNOG; COG1970; Bacteria.
DR HOGENOM; CLU_095787_0_0_0; -.
DR InParanoid; Q8RFE0; -.
DR OMA; AWIIFLM; -.
DR BioCyc; FNUC190304:G1FZS-1351-MON; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR GO; GO:0009992; P:cellular water homeostasis; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IBA:GO_Central.
DR Gene3D; 1.10.1200.120; -; 1.
DR HAMAP; MF_00115; MscL; 1.
DR InterPro; IPR019823; Mechanosensitive_channel_CS.
DR InterPro; IPR001185; MS_channel.
DR InterPro; IPR037673; MSC/AndL.
DR InterPro; IPR036019; MscL_channel.
DR PANTHER; PTHR30266; PTHR30266; 1.
DR Pfam; PF01741; MscL; 1.
DR PRINTS; PR01264; MECHCHANNEL.
DR SUPFAM; SSF81330; SSF81330; 1.
DR TIGRFAMs; TIGR00220; mscL; 1.
DR PROSITE; PS01327; MSCL; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..142
FT /note="Large-conductance mechanosensitive channel"
FT /id="PRO_0000238000"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00115"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00115"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00115"
SQ SEQUENCE 142 AA; 15407 MW; A9BA77E954C57192 CRC64;
MVLGGLMKLF DEFKAFVMRG NVVDLAVGVI IGAAFGKIVT SLVNDIFMPI IGMIIGNIDF
SSLVIKLGEP VEGAEQAAIR YGMFIQEIVN FLIIALCVFV AIKLINKLQK KKEEASAPAP
GPTKEEVLLT EIRDALNKIA EK
