6PGL_THEMA
ID 6PGL_THEMA Reviewed; 220 AA.
AC Q9X0N8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=6-phosphogluconolactonase;
DE Short=6PGL;
DE EC=3.1.1.31;
GN Name=pgl; Synonyms=devB; OrderedLocusNames=TM_1154;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AE000512; AAD36230.1; -; Genomic_DNA.
DR PIR; F72289; F72289.
DR RefSeq; NP_228960.1; NC_000853.1.
DR RefSeq; WP_008195599.1; NZ_CP011107.1.
DR PDB; 1PBT; X-ray; 1.70 A; A=1-220.
DR PDB; 1VL1; X-ray; 1.55 A; A=1-220.
DR PDBsum; 1PBT; -.
DR PDBsum; 1VL1; -.
DR AlphaFoldDB; Q9X0N8; -.
DR SMR; Q9X0N8; -.
DR STRING; 243274.THEMA_08570; -.
DR DrugBank; DB04272; Citric acid.
DR DrugBank; DB01942; Formic acid.
DR EnsemblBacteria; AAD36230; AAD36230; TM_1154.
DR KEGG; tma:TM1154; -.
DR eggNOG; COG0363; Bacteria.
DR InParanoid; Q9X0N8; -.
DR OMA; YQLFEFE; -.
DR OrthoDB; 1828393at2; -.
DR UniPathway; UPA00115; UER00409.
DR EvolutionaryTrace; Q9X0N8; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Reference proteome.
FT CHAIN 1..220
FT /note="6-phosphogluconolactonase"
FT /id="PRO_0000090108"
FT STRAND 4..11
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 13..31
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 35..39
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 45..52
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 62..72
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 80..87
FT /evidence="ECO:0007829|PDB:1VL1"
FT TURN 88..91
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 108..122
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 127..131
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 145..148
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 151..156
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:1VL1"
FT TURN 161..164
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 167..170
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 172..175
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 179..187
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 188..198
FT /evidence="ECO:0007829|PDB:1VL1"
FT HELIX 204..207
FT /evidence="ECO:0007829|PDB:1VL1"
FT STRAND 211..219
FT /evidence="ECO:0007829|PDB:1VL1"
SQ SEQUENCE 220 AA; 25325 MW; 9B0FD07EE01E60C3 CRC64;
MEKTVIYLLE DGYVDFVVEK IRTKMEKLLE EKDKIFVVLA GGRTPLPVYE KLAEQKFPWN
RIHFFLSDER YVPLDSDQSN FRNINEVLFS RAKIPSGNVH YVDTSLPIEK ACEKYEREIR
SATDQFDLAI LGMGPDGHVA SIFDLETGNK DNLVTFTDPS GDPKVPRVTL TFRALNTSLY
VLFLIRGKEK INRLTEILKD TPLPAYFVRG KEKTVWFVGK
