MSCL_RENSM
ID MSCL_RENSM Reviewed; 133 AA.
AC A9WMF7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Large-conductance mechanosensitive channel {ECO:0000255|HAMAP-Rule:MF_00115};
GN Name=mscL {ECO:0000255|HAMAP-Rule:MF_00115};
GN OrderedLocusNames=RSal33209_1734;
OS Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 /
OS NBRC 15589 / NCIMB 2235).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Renibacterium.
OX NCBI_TaxID=288705;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235;
RX PubMed=18723615; DOI=10.1128/jb.00721-08;
RA Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S.,
RA Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H.,
RA Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.;
RT "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests
RT reductive evolution away from an environmental Arthrobacter ancestor.";
RL J. Bacteriol. 190:6970-6982(2008).
CC -!- FUNCTION: Channel that opens in response to stretch forces in the
CC membrane lipid bilayer. May participate in the regulation of osmotic
CC pressure changes within the cell. {ECO:0000255|HAMAP-Rule:MF_00115}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000255|HAMAP-Rule:MF_00115}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00115};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00115}.
CC -!- SIMILARITY: Belongs to the MscL family. {ECO:0000255|HAMAP-
CC Rule:MF_00115}.
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DR EMBL; CP000910; ABY23470.1; -; Genomic_DNA.
DR RefSeq; WP_012245142.1; NC_010168.1.
DR AlphaFoldDB; A9WMF7; -.
DR SMR; A9WMF7; -.
DR STRING; 288705.RSal33209_1734; -.
DR TCDB; 1.A.22.1.9; the large conductance mechanosensitive ion channel (mscl) family.
DR EnsemblBacteria; ABY23470; ABY23470; RSal33209_1734.
DR KEGG; rsa:RSal33209_1734; -.
DR eggNOG; COG1970; Bacteria.
DR HOGENOM; CLU_095787_1_0_11; -.
DR OMA; FKNFIMK; -.
DR OrthoDB; 1863650at2; -.
DR Proteomes; UP000002007; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1200.120; -; 1.
DR HAMAP; MF_00115; MscL; 1.
DR InterPro; IPR019823; Mechanosensitive_channel_CS.
DR InterPro; IPR001185; MS_channel.
DR InterPro; IPR037673; MSC/AndL.
DR InterPro; IPR036019; MscL_channel.
DR PANTHER; PTHR30266; PTHR30266; 1.
DR Pfam; PF01741; MscL; 1.
DR PRINTS; PR01264; MECHCHANNEL.
DR SUPFAM; SSF81330; SSF81330; 1.
DR TIGRFAMs; TIGR00220; mscL; 1.
DR PROSITE; PS01327; MSCL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..133
FT /note="Large-conductance mechanosensitive channel"
FT /id="PRO_1000076044"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00115"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00115"
SQ SEQUENCE 133 AA; 14273 MW; 22815655BEEEB376 CRC64;
MIKGFRDFIL KGNVVDLAVA VVIGAAFGTV VTTLVNNIIM PLIAGIVGKP SFNDVWAFQI
GSDPANKLLL GAFITVLLNF VIIAAAIYFM VVVPMNHVIA RRNAKLGIKA GEETPDPQIV
LLTEIRDALK SRS