MSD1_AMARI
ID MSD1_AMARI Reviewed; 35 AA.
AC A0A023IWM6;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=MSDIN-like toxin proprotein 1 {ECO:0000303|PubMed:24613547};
DE Contains:
DE RecName: Full=Toxin MSD1 {ECO:0000305|PubMed:24613547};
DE Flags: Precursor;
OS Amanita rimosa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Amanitaceae; Amanita.
OX NCBI_TaxID=580330;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=24613547; DOI=10.1016/j.toxicon.2014.02.020;
RA Li P., Deng W., Li T.;
RT "The molecular diversity of toxin gene families in lethal Amanita
RT mushrooms.";
RL Toxicon 83:59-68(2014).
CC -!- FUNCTION: Probable toxin that belongs to the MSDIN-like toxin family
CC responsible for a large number of food poisoning cases and deaths
CC (PubMed:24613547). {ECO:0000305|PubMed:24613547}.
CC -!- PTM: Processed by the macrocyclase-peptidase enzyme POPB to yield a
CC toxic cyclic decapeptide (By similarity). POPB first removes 10
CC residues from the N-terminus (By similarity). Conformational trapping
CC of the remaining peptide forces the enzyme to release this intermediate
CC rather than proceed to macrocyclization (By similarity). The enzyme
CC rebinds the remaining peptide in a different conformation and catalyzes
CC macrocyclization of the N-terminal 10 residues (By similarity).
CC {ECO:0000250|UniProtKB:A0A067SLB9}.
CC -!- SIMILARITY: Belongs to the MSDIN fungal toxin family. {ECO:0000305}.
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DR EMBL; KF552087; AHB18715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A023IWM6; -.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR027582; Amanitin/phalloidin.
DR TIGRFAMs; TIGR04309; amanitin; 1.
PE 3: Inferred from homology;
KW Toxin.
FT PROPEP 1..10
FT /evidence="ECO:0000305|PubMed:24613547"
FT /id="PRO_0000443707"
FT PEPTIDE 11..20
FT /note="Toxin MSD1"
FT /evidence="ECO:0000305|PubMed:24613547"
FT /id="PRO_0000443708"
FT PROPEP 21..35
FT /evidence="ECO:0000305|PubMed:24613547"
FT /id="PRO_0000443709"
FT CROSSLNK 11..20
FT /note="Cyclopeptide (Ile-Pro)"
FT /evidence="ECO:0000305|PubMed:24613547"
SQ SEQUENCE 35 AA; 3880 MW; E5A6BA2D4EAC3212 CRC64;
MSDINATRLP IIIVLGLIIP LCVSDIEMIL TRGER