MSD1_HUMAN
ID MSD1_HUMAN Reviewed; 278 AA.
AC Q6ZTZ1; C9J6V0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 1;
GN Name=MSANTD1; Synonyms=C4orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-243.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86436.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AL390059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK126094; BAC86436.1; ALT_SEQ; mRNA.
DR CCDS; CCDS47003.1; -.
DR RefSeq; NP_001036155.1; NM_001042690.1.
DR AlphaFoldDB; Q6ZTZ1; -.
DR SMR; Q6ZTZ1; -.
DR STRING; 9606.ENSP00000411584; -.
DR iPTMnet; Q6ZTZ1; -.
DR PhosphoSitePlus; Q6ZTZ1; -.
DR BioMuta; MSANTD1; -.
DR DMDM; 284018071; -.
DR EPD; Q6ZTZ1; -.
DR PaxDb; Q6ZTZ1; -.
DR PRIDE; Q6ZTZ1; -.
DR ProteomicsDB; 68302; -.
DR Antibodypedia; 57468; 49 antibodies from 8 providers.
DR DNASU; 345222; -.
DR Ensembl; ENST00000438480.7; ENSP00000411584.2; ENSG00000188981.11.
DR GeneID; 345222; -.
DR KEGG; hsa:345222; -.
DR MANE-Select; ENST00000438480.7; ENSP00000411584.2; NM_001042690.2; NP_001036155.1.
DR UCSC; uc003ggs.4; human.
DR CTD; 345222; -.
DR DisGeNET; 345222; -.
DR GeneCards; MSANTD1; -.
DR HGNC; HGNC:33741; MSANTD1.
DR HPA; ENSG00000188981; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q6ZTZ1; -.
DR OpenTargets; ENSG00000188981; -.
DR PharmGKB; PA162379942; -.
DR VEuPathDB; HostDB:ENSG00000188981; -.
DR eggNOG; KOG4282; Eukaryota.
DR GeneTree; ENSGT00390000002245; -.
DR InParanoid; Q6ZTZ1; -.
DR OMA; FQFRRLK; -.
DR OrthoDB; 1177523at2759; -.
DR PhylomeDB; Q6ZTZ1; -.
DR TreeFam; TF331923; -.
DR PathwayCommons; Q6ZTZ1; -.
DR BioGRID-ORCS; 345222; 9 hits in 1068 CRISPR screens.
DR GenomeRNAi; 345222; -.
DR Pharos; Q6ZTZ1; Tdark.
DR PRO; PR:Q6ZTZ1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6ZTZ1; protein.
DR Bgee; ENSG00000188981; Expressed in mucosa of stomach and 88 other tissues.
DR ExpressionAtlas; Q6ZTZ1; baseline and differential.
DR Genevisible; Q6ZTZ1; HS.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR026095; Myb/SANT-like_DNA-bd_dom_prot.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR PANTHER; PTHR22666; PTHR22666; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..278
FT /note="Myb/SANT-like DNA-binding domain-containing protein
FT 1"
FT /id="PRO_0000321819"
FT DOMAIN 44..129
FT /note="Myb-like"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 64
FT /note="E -> G (in Ref. 2; BAC86436)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 31632 MW; 9A522BBEFF0ADB6E CRC64;
MVRGAGPGPS LSALSHPTGA SGMAAAEGPG YLVSPQAEKH RRARNWTDAE MRGLMLVWEE
FFDELKQTKR NAKVYEKMAS KLFEMTGERR LGEEIKIKIT NMTFQYRKLK CMTDSESAPP
DWPYYLAIDG ILAKVPESCD GKLPDSQPPG PSTSQTEASL SPPAKSTPLY FPYNQCSYEG
RFEDDRSDSS SSLLSLKFRS EERPVKKRKV QSCHLQKKQL RLLEAMVEEQ RRLSRAVEET
CREVRRVLDQ QHILQVQSLQ LQERMMSLLE RIITKSSV
