位置:首页 > 蛋白库 > MSD2_HUMAN
MSD2_HUMAN
ID   MSD2_HUMAN              Reviewed;         559 AA.
AC   Q6P1R3; B3KRY6; Q9H042; Q9H5K8;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 2;
GN   Name=MSANTD2; Synonyms=C11orf61;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Hepatoma, and Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT   phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-48, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [8]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-268, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
RN   [9]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-268, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA   Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL   Cell Rep. 10:1778-1791(2015).
RN   [10]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-268 AND LYS-343, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25755297; DOI=10.1074/mcp.o114.044792;
RA   Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "System-wide analysis of SUMOylation dynamics in response to replication
RT   stress reveals novel small ubiquitin-like modified target proteins and
RT   acceptor lysines relevant for genome stability.";
RL   Mol. Cell. Proteomics 14:1419-1434(2015).
RN   [11]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-268 AND LYS-343, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6P1R3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P1R3-2; Sequence=VSP_022705;
CC       Name=3;
CC         IsoId=Q6P1R3-3; Sequence=VSP_022706;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK026995; BAB15618.1; -; mRNA.
DR   EMBL; AK092413; BAG52548.1; -; mRNA.
DR   EMBL; AL512691; CAC21648.1; -; mRNA.
DR   EMBL; BC064919; AAH64919.1; -; mRNA.
DR   CCDS; CCDS73408.1; -. [Q6P1R3-2]
DR   CCDS; CCDS76491.1; -. [Q6P1R3-1]
DR   CCDS; CCDS8454.1; -. [Q6P1R3-3]
DR   RefSeq; NP_001294956.1; NM_001308027.1. [Q6P1R3-1]
DR   RefSeq; NP_001299848.1; NM_001312919.1.
DR   RefSeq; NP_001299849.1; NM_001312920.1. [Q6P1R3-2]
DR   RefSeq; NP_001299850.1; NM_001312921.1. [Q6P1R3-2]
DR   RefSeq; NP_078907.2; NM_024631.3. [Q6P1R3-3]
DR   RefSeq; XP_006718968.1; XM_006718905.1. [Q6P1R3-2]
DR   RefSeq; XP_006718969.1; XM_006718906.3. [Q6P1R3-2]
DR   RefSeq; XP_016873784.1; XM_017018295.1.
DR   RefSeq; XP_016873785.1; XM_017018296.1. [Q6P1R3-2]
DR   RefSeq; XP_016873786.1; XM_017018297.1. [Q6P1R3-2]
DR   RefSeq; XP_016873787.1; XM_017018298.1. [Q6P1R3-2]
DR   RefSeq; XP_016873788.1; XM_017018299.1.
DR   AlphaFoldDB; Q6P1R3; -.
DR   BioGRID; 122807; 13.
DR   IntAct; Q6P1R3; 12.
DR   STRING; 9606.ENSP00000239614; -.
DR   iPTMnet; Q6P1R3; -.
DR   PhosphoSitePlus; Q6P1R3; -.
DR   BioMuta; MSANTD2; -.
DR   DMDM; 74737168; -.
DR   EPD; Q6P1R3; -.
DR   jPOST; Q6P1R3; -.
DR   MassIVE; Q6P1R3; -.
DR   MaxQB; Q6P1R3; -.
DR   PeptideAtlas; Q6P1R3; -.
DR   PRIDE; Q6P1R3; -.
DR   ProteomicsDB; 66869; -. [Q6P1R3-1]
DR   ProteomicsDB; 66870; -. [Q6P1R3-2]
DR   ProteomicsDB; 66871; -. [Q6P1R3-3]
DR   Antibodypedia; 49903; 32 antibodies from 11 providers.
DR   DNASU; 79684; -.
DR   Ensembl; ENST00000239614.8; ENSP00000239614.4; ENSG00000120458.13. [Q6P1R3-3]
DR   Ensembl; ENST00000374979.8; ENSP00000364118.3; ENSG00000120458.13. [Q6P1R3-1]
DR   Ensembl; ENST00000526629.1; ENSP00000435705.1; ENSG00000120458.13. [Q6P1R3-2]
DR   GeneID; 79684; -.
DR   KEGG; hsa:79684; -.
DR   MANE-Select; ENST00000374979.8; ENSP00000364118.3; NM_001308027.2; NP_001294956.1.
DR   UCSC; uc001qay.2; human. [Q6P1R3-1]
DR   CTD; 79684; -.
DR   DisGeNET; 79684; -.
DR   GeneCards; MSANTD2; -.
DR   HGNC; HGNC:26266; MSANTD2.
DR   HPA; ENSG00000120458; Low tissue specificity.
DR   neXtProt; NX_Q6P1R3; -.
DR   OpenTargets; ENSG00000120458; -.
DR   PharmGKB; PA143485356; -.
DR   VEuPathDB; HostDB:ENSG00000120458; -.
DR   eggNOG; ENOG502QU4E; Eukaryota.
DR   GeneTree; ENSGT00390000013593; -.
DR   HOGENOM; CLU_028535_1_0_1; -.
DR   InParanoid; Q6P1R3; -.
DR   OMA; FSQEDWG; -.
DR   OrthoDB; 747790at2759; -.
DR   PhylomeDB; Q6P1R3; -.
DR   TreeFam; TF331593; -.
DR   PathwayCommons; Q6P1R3; -.
DR   SignaLink; Q6P1R3; -.
DR   BioGRID-ORCS; 79684; 12 hits in 1078 CRISPR screens.
DR   ChiTaRS; MSANTD2; human.
DR   GenomeRNAi; 79684; -.
DR   Pharos; Q6P1R3; Tdark.
DR   PRO; PR:Q6P1R3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6P1R3; protein.
DR   Bgee; ENSG00000120458; Expressed in caput epididymis and 191 other tissues.
DR   ExpressionAtlas; Q6P1R3; baseline and differential.
DR   Genevisible; Q6P1R3; HS.
DR   InterPro; IPR042792; MSANTD2.
DR   InterPro; IPR044822; Myb_DNA-bind_4.
DR   PANTHER; PTHR46933; PTHR46933; 1.
DR   Pfam; PF13837; Myb_DNA-bind_4; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..559
FT                   /note="Myb/SANT-like DNA-binding domain-containing protein
FT                   2"
FT                   /id="PRO_0000274301"
FT   DOMAIN          103..173
FT                   /note="Myb-like"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZR2"
FT   MOD_RES         27
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZR2"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZR2"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18220336,
FT                   ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163"
FT   MOD_RES         436
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZR2"
FT   CROSSLNK        268
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25218447,
FT                   ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364,
FT                   ECO:0007744|PubMed:28112733"
FT   CROSSLNK        343
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25755297,
FT                   ECO:0007744|PubMed:28112733"
FT   VAR_SEQ         1..230
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_022705"
FT   VAR_SEQ         171..222
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_022706"
FT   CONFLICT        370
FT                   /note="N -> D (in Ref. 1; BAB15618)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        382
FT                   /note="E -> K (in Ref. 1; BAB15618)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   559 AA;  61319 MW;  92063815ADDE0E5F CRC64;
     MAAPCGSELP ANSPLKIPKM EVLSPASPGG LSDGNPSLSD PSTPRGASPL GPGSAAGSGA
     AASGGLGLGL GGRSAASSSV SFSPGGGGGG AAAAAAAACR GMSWTPAETN ALIAVWGNER
     LVEARYQQLE GAGTVFGSKA PGPAMYERVS RALAELGYER TPSQCRERIK TLRRCYSRVK
     EHGVGKRKSS YTFEQLEQVF GQGGWDAQPC QPVLINSSGL YQELESDGST MEDYSQEDWG
     NHSQDLHGYP TDQELDEIPV TKRTLKIKQE SSEEAQKRDI MQNIVQILES VQLKWELFQS
     WTDFSRLHLS NKLAIFGIGY NTRWKEDIRY HYAEISSQVP LGKRLREYFN SEKPEGRIIM
     TRVQKMNWKN VYYKFLEITI SEARCLELHM EIDWIPIAHS KPTGGNVVQY LLPGGIPKSP
     GLYAIGYEEC IERPLSPHME QSSLDPGKEG RVDLETLSAQ ASLQVEIEPT RIIYCYLGIA
     EVRTLQQCLF LHFQANTKTF SKDWVGINGF LSQNCIVDPG VSPKSIYIKF VEVERDFLSA
     GSLVECLEKA IGYPLKFNN
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024