MSD2_MOUSE
ID MSD2_MOUSE Reviewed; 559 AA.
AC Q6NZR2; Q8R3V3;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 2;
GN Name=Msantd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-27; SER-32; SER-48
RP AND SER-436, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NZR2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZR2-2; Sequence=VSP_022707;
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DR EMBL; AK153989; BAE32299.1; -; mRNA.
DR EMBL; BC024479; AAH24479.1; -; mRNA.
DR EMBL; BC066002; AAH66002.1; -; mRNA.
DR CCDS; CCDS22978.1; -. [Q6NZR2-1]
DR RefSeq; NP_666334.2; NM_146222.2. [Q6NZR2-1]
DR RefSeq; XP_006510295.1; XM_006510232.3. [Q6NZR2-2]
DR RefSeq; XP_006510296.1; XM_006510233.3.
DR AlphaFoldDB; Q6NZR2; -.
DR BioGRID; 231628; 1.
DR IntAct; Q6NZR2; 1.
DR STRING; 10090.ENSMUSP00000043329; -.
DR iPTMnet; Q6NZR2; -.
DR PhosphoSitePlus; Q6NZR2; -.
DR EPD; Q6NZR2; -.
DR jPOST; Q6NZR2; -.
DR MaxQB; Q6NZR2; -.
DR PaxDb; Q6NZR2; -.
DR PeptideAtlas; Q6NZR2; -.
DR PRIDE; Q6NZR2; -.
DR ProteomicsDB; 291445; -. [Q6NZR2-1]
DR ProteomicsDB; 291446; -. [Q6NZR2-2]
DR Antibodypedia; 49903; 32 antibodies from 11 providers.
DR DNASU; 235184; -.
DR Ensembl; ENSMUST00000048604; ENSMUSP00000043329; ENSMUSG00000042138. [Q6NZR2-1]
DR Ensembl; ENSMUST00000239463; ENSMUSP00000159374; ENSMUSG00000042138. [Q6NZR2-1]
DR GeneID; 235184; -.
DR KEGG; mmu:235184; -.
DR UCSC; uc009ouy.1; mouse. [Q6NZR2-1]
DR CTD; 79684; -.
DR MGI; MGI:2384579; Msantd2.
DR VEuPathDB; HostDB:ENSMUSG00000042138; -.
DR eggNOG; ENOG502QU4E; Eukaryota.
DR GeneTree; ENSGT00390000013593; -.
DR HOGENOM; CLU_028535_1_0_1; -.
DR InParanoid; Q6NZR2; -.
DR OMA; FSQEDWG; -.
DR OrthoDB; 747790at2759; -.
DR PhylomeDB; Q6NZR2; -.
DR TreeFam; TF331593; -.
DR BioGRID-ORCS; 235184; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Msantd2; mouse.
DR PRO; PR:Q6NZR2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6NZR2; protein.
DR Bgee; ENSMUSG00000042138; Expressed in retinal neural layer and 249 other tissues.
DR ExpressionAtlas; Q6NZR2; baseline and differential.
DR Genevisible; Q6NZR2; MM.
DR InterPro; IPR042792; MSANTD2.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR PANTHER; PTHR46933; PTHR46933; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..559
FT /note="Myb/SANT-like DNA-binding domain-containing protein
FT 2"
FT /id="PRO_0000274302"
FT DOMAIN 103..173
FT /note="Myb-like"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1R3"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 32
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 436
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 268
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6P1R3"
FT CROSSLNK 343
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6P1R3"
FT VAR_SEQ 1..230
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022707"
SQ SEQUENCE 559 AA; 61361 MW; FB91A8149F041990 CRC64;
MAAPCGSELP ANSPLKIPKM EVLSPASPGD LSDGNPSLSD PSTPRGASPL GPGSAAGSGA
AASGGLGLGL GGRGAASSSV SFSPGGGSGG AAAAAAAACR GMSWTPAETN ALIAVWGNER
LVEARYQQLE GAGTVFGSKA PGPAMYERVS RALAELGYER TPSQCRERIK TLRRCYSRVK
EHGVGKRKSS YTFEQLEQVF GQGGWDAQPC QPVLINSSGL YQELESDGST MEDYSQEDWG
NHSQELHGYP TDQELDEMPV SKRTLKIKQE SSEEAQKRDT MQNIVQILES VQLKWELFQS
WTDFSRLHLS NKLAIFGIGY NTRWKEDIRY HYAEISSQVP LGKRLREYFN SEKPEGRIIM
TRVQKMNWKN VYYKFLEITI SEARCLELHM EIDWIPIAHS KPTGGNVVQY LLPGGIPKSP
GLYAIGYEEC IERPLSPDVE RHALDPGKEG RVDLETLSAQ ASLQVEVEPT RIIYCYLGIA
EVRTLQQCLF LHFQANAKTF SKEWVGINGF LSQNCIVDPG VSPKSIYIKF VEVERDFLSA
GSLVECLEKA IGYPLKFNN
