MSD3_MOUSE
ID MSD3_MOUSE Reviewed; 275 AA.
AC Q9CR78; Q9CYY5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 3;
GN Name=Msantd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the MSANTD3 family. {ECO:0000305}.
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DR EMBL; AK011381; BAB27581.1; -; mRNA.
DR EMBL; AK013199; BAB28708.1; -; mRNA.
DR EMBL; AK017795; BAB30936.1; -; mRNA.
DR EMBL; AK075956; BAC36081.1; -; mRNA.
DR EMBL; AL772151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052696; AAH52696.1; -; mRNA.
DR CCDS; CCDS18167.1; -.
DR RefSeq; NP_001139396.1; NM_001145924.1.
DR RefSeq; NP_001139397.1; NM_001145925.1.
DR RefSeq; NP_082413.2; NM_028137.3.
DR RefSeq; XP_006538250.1; XM_006538187.2.
DR RefSeq; XP_006538251.1; XM_006538188.3.
DR RefSeq; XP_011248388.1; XM_011250086.2.
DR RefSeq; XP_011248389.1; XM_011250087.2.
DR AlphaFoldDB; Q9CR78; -.
DR SMR; Q9CR78; -.
DR BioGRID; 211633; 2.
DR MINT; Q9CR78; -.
DR STRING; 10090.ENSMUSP00000103332; -.
DR iPTMnet; Q9CR78; -.
DR PhosphoSitePlus; Q9CR78; -.
DR PaxDb; Q9CR78; -.
DR PeptideAtlas; Q9CR78; -.
DR PRIDE; Q9CR78; -.
DR ProteomicsDB; 291512; -.
DR Antibodypedia; 34901; 77 antibodies from 13 providers.
DR DNASU; 66665; -.
DR Ensembl; ENSMUST00000061135; ENSMUSP00000056551; ENSMUSG00000039693.
DR Ensembl; ENSMUST00000064807; ENSMUSP00000065785; ENSMUSG00000039693.
DR Ensembl; ENSMUST00000107704; ENSMUSP00000103332; ENSMUSG00000039693.
DR GeneID; 66665; -.
DR KEGG; mmu:66665; -.
DR UCSC; uc008svg.2; mouse.
DR CTD; 91283; -.
DR MGI; MGI:1913915; Msantd3.
DR VEuPathDB; HostDB:ENSMUSG00000039693; -.
DR eggNOG; ENOG502RFDD; Eukaryota.
DR GeneTree; ENSGT00390000007901; -.
DR HOGENOM; CLU_065066_0_0_1; -.
DR InParanoid; Q9CR78; -.
DR OMA; FQVCEGT; -.
DR OrthoDB; 1083477at2759; -.
DR PhylomeDB; Q9CR78; -.
DR TreeFam; TF328595; -.
DR BioGRID-ORCS; 66665; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Msantd3; mouse.
DR PRO; PR:Q9CR78; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CR78; protein.
DR Bgee; ENSMUSG00000039693; Expressed in animal zygote and 158 other tissues.
DR Genevisible; Q9CR78; MM.
DR InterPro; IPR026709; Msantd3.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR21632; PTHR21632; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..275
FT /note="Myb/SANT-like DNA-binding domain-containing protein
FT 3"
FT /id="PRO_0000292591"
FT DOMAIN 13..78
FT /note="Myb-like"
FT COILED 211..247
FT /evidence="ECO:0000255"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96H12"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96H12"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 154
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96H12"
FT CONFLICT 172
FT /note="C -> R (in Ref. 2; BAB28708)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 32324 MW; 15CD6B3DE4DD7CC4 CRC64;
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ ALAHEYNSQP
SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSGSPL LSSHVLDKEK ISSMLPEQLY
FLQSPPEEEP EYHQDAAAQE SFAVSNRELC EDEKEFGPFP VCEGTSQPEP SCSAVRITAN
KNYRSKTPQE GALKKMHEEE HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK
MEVLNKKKMY WERKLQTFTK EWPVSSFNRP FPNSP
