MSD4_HUMAN
ID MSD4_HUMAN Reviewed; 345 AA.
AC Q8NCY6; Q96JK1; Q96JZ3; Q9H2N4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 4;
DE AltName: Full=Myb/SANT-like DNA-binding domain containing 4 with coiled-coils;
GN Name=MSANTD4; Synonyms=KIAA1826; ORFNames=DC25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-281.
RC TISSUE=Dendritic cell;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RT "A novel gene from human dendritic cells.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-188, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-142, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25755297; DOI=10.1074/mcp.o114.044792;
RA Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V.,
RA Vertegaal A.C.;
RT "System-wide analysis of SUMOylation dynamics in response to replication
RT stress reveals novel small ubiquitin-like modified target proteins and
RT acceptor lysines relevant for genome stability.";
RL Mol. Cell. Proteomics 14:1419-1434(2015).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-9; LYS-114; LYS-142; LYS-237;
RP LYS-254 AND LYS-273, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q8NCY6; Q13895: BYSL; NbExp=3; IntAct=EBI-7850168, EBI-358049;
CC Q8NCY6; Q9UER7: DAXX; NbExp=3; IntAct=EBI-7850168, EBI-77321;
CC Q8NCY6; P63211: GNGT1; NbExp=3; IntAct=EBI-7850168, EBI-10220715;
CC Q8NCY6; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-7850168, EBI-739832;
CC Q8NCY6; Q96T60: PNKP; NbExp=3; IntAct=EBI-7850168, EBI-1045072;
CC Q8NCY6; P25786: PSMA1; NbExp=3; IntAct=EBI-7850168, EBI-359352;
CC Q8NCY6; Q15311: RALBP1; NbExp=4; IntAct=EBI-7850168, EBI-749285;
CC Q8NCY6; Q15560: TCEA2; NbExp=3; IntAct=EBI-7850168, EBI-710310;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44625.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB47455.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB55371.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB058729; BAB47455.1; ALT_INIT; mRNA.
DR EMBL; AK293050; BAF85739.1; -; mRNA.
DR EMBL; AL834523; CAD39179.1; -; mRNA.
DR EMBL; CH471065; EAW67071.1; -; Genomic_DNA.
DR EMBL; BC041118; AAH41118.1; -; mRNA.
DR EMBL; AF253976; AAG44625.1; ALT_FRAME; mRNA.
DR EMBL; AK027790; BAB55371.1; ALT_INIT; mRNA.
DR CCDS; CCDS31663.1; -.
DR RefSeq; NP_001305676.1; NM_001318747.1.
DR RefSeq; NP_001305677.1; NM_001318748.1.
DR RefSeq; NP_001305678.1; NM_001318749.1.
DR RefSeq; NP_001305679.1; NM_001318750.1.
DR RefSeq; NP_115800.1; NM_032424.2.
DR RefSeq; XP_011541324.1; XM_011543022.2.
DR RefSeq; XP_016873905.1; XM_017018416.1.
DR RefSeq; XP_016873906.1; XM_017018417.1.
DR AlphaFoldDB; Q8NCY6; -.
DR SMR; Q8NCY6; -.
DR BioGRID; 124077; 10.
DR IntAct; Q8NCY6; 10.
DR MINT; Q8NCY6; -.
DR STRING; 9606.ENSP00000304713; -.
DR iPTMnet; Q8NCY6; -.
DR PhosphoSitePlus; Q8NCY6; -.
DR BioMuta; MSANTD4; -.
DR DMDM; 74760164; -.
DR EPD; Q8NCY6; -.
DR jPOST; Q8NCY6; -.
DR MassIVE; Q8NCY6; -.
DR MaxQB; Q8NCY6; -.
DR PaxDb; Q8NCY6; -.
DR PeptideAtlas; Q8NCY6; -.
DR PRIDE; Q8NCY6; -.
DR ProteomicsDB; 72967; -.
DR Antibodypedia; 54341; 31 antibodies from 10 providers.
DR DNASU; 84437; -.
DR Ensembl; ENST00000301919.9; ENSP00000304713.4; ENSG00000170903.12.
DR GeneID; 84437; -.
DR KEGG; hsa:84437; -.
DR MANE-Select; ENST00000301919.9; ENSP00000304713.4; NM_032424.3; NP_115800.1.
DR UCSC; uc001piz.3; human.
DR CTD; 84437; -.
DR GeneCards; MSANTD4; -.
DR HGNC; HGNC:29383; MSANTD4.
DR HPA; ENSG00000170903; Low tissue specificity.
DR neXtProt; NX_Q8NCY6; -.
DR OpenTargets; ENSG00000170903; -.
DR PharmGKB; PA143485519; -.
DR VEuPathDB; HostDB:ENSG00000170903; -.
DR eggNOG; ENOG502RGM9; Eukaryota.
DR GeneTree; ENSGT00440000039469; -.
DR HOGENOM; CLU_066150_0_0_1; -.
DR InParanoid; Q8NCY6; -.
DR OMA; MGFAIES; -.
DR OrthoDB; 1027153at2759; -.
DR PhylomeDB; Q8NCY6; -.
DR TreeFam; TF330965; -.
DR PathwayCommons; Q8NCY6; -.
DR SignaLink; Q8NCY6; -.
DR BioGRID-ORCS; 84437; 13 hits in 1081 CRISPR screens.
DR ChiTaRS; MSANTD4; human.
DR GeneWiki; KIAA1826; -.
DR GenomeRNAi; 84437; -.
DR Pharos; Q8NCY6; Tdark.
DR PRO; PR:Q8NCY6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NCY6; protein.
DR Bgee; ENSG00000170903; Expressed in tendon of biceps brachii and 184 other tissues.
DR ExpressionAtlas; Q8NCY6; baseline and differential.
DR Genevisible; Q8NCY6; HS.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR InterPro; IPR026162; MSANTD4.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR21732; PTHR21732; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..345
FT /note="Myb/SANT-like DNA-binding domain-containing protein
FT 4"
FT /id="PRO_0000311830"
FT DOMAIN 4..77
FT /note="Myb-like"
FT REGION 143..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 203..345
FT /evidence="ECO:0000255"
FT COMPBIAS 150..164
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 106
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q501L3"
FT MOD_RES 188
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18220336"
FT CROSSLNK 9
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 114
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 142
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25755297,
FT ECO:0007744|PubMed:28112733"
FT CROSSLNK 237
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 254
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 273
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
SQ SEQUENCE 345 AA; 41150 MW; F60EA447B282F812 CRC64;
MKQLKRKRKS NFSVQETQTL LKEITKRKEV IFSKQLNTTI NVMKRMAWEE IAQCVNAVGE
GEQRTGTEVK RRYLDWRALM KRKRMKANIK LVGSGFPLPS SDLDDSLTEE IDEKIGFRND
ANFDWQNVAD FRDAGGSLTE VKVEEEERDP QSPEFEIEEE EEMLSSVIPD SRRENELPDF
PHIDEFFTLN STPSRSAYDE PHLLVNIEKQ KLELEKRRLD IEAERLQVEK ERLQIEKERL
RHLDMEHERL QLEKERLQIE REKLRLQIVN SEKPSLENEL GQGEKSMLQP QDIETEKLKL
ERERLQLEKD RLQFLKFESE KLQIEKERLQ VEKDRLRIQK EGHLQ
