MSGN1_DANRE
ID MSGN1_DANRE Reviewed; 131 AA.
AC Q90ZL1; A8E564; Q568W3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mesogenin-1;
DE AltName: Full=MesP-related bHLH factor;
DE AltName: Full=Paraxial mesoderm-specific expression and regulatory capacities;
DE AltName: Full=pMesogenin1;
DE Short=pMsgn1;
GN Name=msgn1; Synonyms=mespo; ORFNames=si:ch211-222h17.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=12883008; DOI=10.1073/pnas.1633548100;
RA Goering L.M., Hoshijima K., Hug B., Bisgrove B., Kispert A., Grunwald D.J.;
RT "An interacting network of T-box genes directs gene expression and fate in
RT the zebrafish mesoderm.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:9410-9415(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=12684777; DOI=10.1007/s00427-003-0312-1;
RA Yoo K.-W., Kim C.-H., Park H.-C., Kim S.-H., Kim H.-S., Hong S.-K., Han S.,
RA Rhee M., Huh T.-L.;
RT "Characterization and expression of a presomitic mesoderm-specific mespo
RT gene in zebrafish.";
RL Dev. Genes Evol. 213:203-206(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Alt B., Tautz D., Gajewski M.;
RT "Danio rerio mRNA for zf-pMesogenin.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in specifying the paraxial, but not dorsal,
CC mesoderm. May regulate the expression of T-box transcription factors
CC required for mesoderm formation and differentiation (By similarity).
CC {ECO:0000250, ECO:0000269|PubMed:12883008}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Coexpression of ntl and spt is required for
CC expression.
CC -!- DEVELOPMENTAL STAGE: Expression is first detected in the marginal zone
CC of the blastoderm. Expression becomes more apparent at the germ-ring
CC stage. In the early gastrula, expressed only in hypoblast cells of the
CC germ ring. At mid-gastrula stage, expressed in ventrolateral mesoderm
CC and is subsequently restricted to the segmental plate at late gastrula
CC stage. At the segmentation period, expressed in the presomitic mesoderm
CC including the tailbud. Expression is also detected in the adaxial cells
CC in the vicinity of the presomitic mesoderm.
CC {ECO:0000269|PubMed:12684777}.
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DR EMBL; AY150226; AAN65633.1; -; mRNA.
DR EMBL; AF409108; AAN75769.1; -; mRNA.
DR EMBL; AJ309314; CAC38843.1; -; mRNA.
DR EMBL; BX640590; CAH68945.1; -; Genomic_DNA.
DR EMBL; BX890562; CAK04569.1; -; Genomic_DNA.
DR EMBL; BC092683; AAH92683.1; -; mRNA.
DR EMBL; BC153476; AAI53477.1; -; mRNA.
DR RefSeq; NP_878302.1; NM_182882.2.
DR AlphaFoldDB; Q90ZL1; -.
DR SMR; Q90ZL1; -.
DR STRING; 7955.ENSDARP00000094435; -.
DR PaxDb; Q90ZL1; -.
DR Ensembl; ENSDART00000103659; ENSDARP00000094435; ENSDARG00000070546.
DR GeneID; 360135; -.
DR KEGG; dre:360135; -.
DR CTD; 343930; -.
DR ZFIN; ZDB-GENE-030722-1; msgn1.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00530000063712; -.
DR HOGENOM; CLU_084234_1_1_1; -.
DR InParanoid; Q90ZL1; -.
DR OMA; SSPEMCY; -.
DR OrthoDB; 1493381at2759; -.
DR PhylomeDB; Q90ZL1; -.
DR TreeFam; TF325707; -.
DR PRO; PR:Q90ZL1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000070546; Expressed in tail bud paraxial mesoderm and 11 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007498; P:mesoderm development; IGI:ZFIN.
DR GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR GO; GO:0048342; P:paraxial mesodermal cell differentiation; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:ZFIN.
DR GO; GO:0007525; P:somatic muscle development; IGI:ZFIN.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040259; Mesogenin/MesP.
DR PANTHER; PTHR20937; PTHR20937; 2.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..131
FT /note="Mesogenin-1"
FT /id="PRO_0000330033"
FT DOMAIN 70..124
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 22..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 74
FT /note="K -> E (in Ref. 5; AAI53477)"
FT /evidence="ECO:0000305"
FT CONFLICT 115
FT /note="K -> R (in Ref. 5; AAH92683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 14994 MW; 3D1B5786F42AF66E CRC64;
MAQIDVDVFT AKVLSHWDWS REDRSFGDSA SSPESESFDS ACSSPDARSS PTAGCEHAEQ
QKPKVKMSMR RRMKASEREK LRMRSLAEAL HQLRDYLPPG YSRRGQPLTK IQTLKYTIQY
IKELSGILEQ Q
