MSGN1_HUMAN
ID MSGN1_HUMAN Reviewed; 193 AA.
AC A6NI15;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Mesogenin-1;
DE AltName: Full=Paraxial mesoderm-specific mesogenin1;
DE AltName: Full=pMesogenin1;
DE Short=pMsgn1;
GN Name=MSGN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: Involved in specifying the paraxial, but not dorsal,
CC mesoderm. May regulate the expression of T-box transcription factors
CC required for mesoderm formation and differentiation (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC A6NI15; Q10567-3: AP1B1; NbExp=3; IntAct=EBI-11991020, EBI-11978055;
CC A6NI15; A0A0C4DG94: ATP11B; NbExp=3; IntAct=EBI-11991020, EBI-11990784;
CC A6NI15; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-11991020, EBI-10826195;
CC A6NI15; P0C7W6: CCDC172; NbExp=3; IntAct=EBI-11991020, EBI-2548868;
CC A6NI15; P78358: CTAG1B; NbExp=3; IntAct=EBI-11991020, EBI-1188472;
CC A6NI15; O14645: DNALI1; NbExp=3; IntAct=EBI-11991020, EBI-395638;
CC A6NI15; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-11991020, EBI-6251402;
CC A6NI15; P54257: HAP1; NbExp=3; IntAct=EBI-11991020, EBI-712814;
CC A6NI15; P41134: ID1; NbExp=5; IntAct=EBI-11991020, EBI-1215527;
CC A6NI15; Q02363: ID2; NbExp=3; IntAct=EBI-11991020, EBI-713450;
CC A6NI15; Q02535: ID3; NbExp=3; IntAct=EBI-11991020, EBI-1387094;
CC A6NI15; P24592: IGFBP6; NbExp=3; IntAct=EBI-11991020, EBI-947015;
CC A6NI15; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-11991020, EBI-712105;
CC A6NI15; O95751: LDOC1; NbExp=3; IntAct=EBI-11991020, EBI-740738;
CC A6NI15; P43360: MAGEA6; NbExp=3; IntAct=EBI-11991020, EBI-1045155;
CC A6NI15; P13349: MYF5; NbExp=3; IntAct=EBI-11991020, EBI-17491620;
CC A6NI15; P24844-2: MYL9; NbExp=3; IntAct=EBI-11991020, EBI-13066228;
CC A6NI15; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-11991020, EBI-10172876;
CC A6NI15; P0C6T2: OST4; NbExp=3; IntAct=EBI-11991020, EBI-18397963;
CC A6NI15; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-11991020, EBI-748621;
CC A6NI15; Q99081-3: TCF12; NbExp=3; IntAct=EBI-11991020, EBI-11952764;
CC A6NI15; P15884-3: TCF4; NbExp=3; IntAct=EBI-11991020, EBI-13636688;
CC A6NI15; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11991020, EBI-11139477;
CC A6NI15; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-11991020, EBI-12090309;
CC A6NI15; Q13077: TRAF1; NbExp=3; IntAct=EBI-11991020, EBI-359224;
CC A6NI15; Q6PF05: TTC23L; NbExp=5; IntAct=EBI-11991020, EBI-8656864;
CC A6NI15; Q9H0C1: ZMYND12; NbExp=5; IntAct=EBI-11991020, EBI-12030590;
CC A6NI15; O95229: ZWINT; NbExp=3; IntAct=EBI-11991020, EBI-1001132;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC093731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42657.1; -.
DR RefSeq; NP_001099039.1; NM_001105569.1.
DR AlphaFoldDB; A6NI15; -.
DR SMR; A6NI15; -.
DR BioGRID; 131280; 40.
DR IntAct; A6NI15; 28.
DR STRING; 9606.ENSP00000281047; -.
DR PhosphoSitePlus; A6NI15; -.
DR BioMuta; MSGN1; -.
DR PaxDb; A6NI15; -.
DR PRIDE; A6NI15; -.
DR Antibodypedia; 64308; 71 antibodies from 13 providers.
DR DNASU; 343930; -.
DR Ensembl; ENST00000281047.4; ENSP00000281047.3; ENSG00000151379.4.
DR GeneID; 343930; -.
DR KEGG; hsa:343930; -.
DR MANE-Select; ENST00000281047.4; ENSP00000281047.3; NM_001105569.3; NP_001099039.1.
DR UCSC; uc010yjt.3; human.
DR CTD; 343930; -.
DR DisGeNET; 343930; -.
DR GeneCards; MSGN1; -.
DR HGNC; HGNC:14907; MSGN1.
DR HPA; ENSG00000151379; Not detected.
DR MIM; 612209; gene.
DR neXtProt; NX_A6NI15; -.
DR OpenTargets; ENSG00000151379; -.
DR PharmGKB; PA142671315; -.
DR VEuPathDB; HostDB:ENSG00000151379; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00530000063712; -.
DR HOGENOM; CLU_084234_1_0_1; -.
DR InParanoid; A6NI15; -.
DR OMA; SSWDWKN; -.
DR OrthoDB; 1493381at2759; -.
DR PhylomeDB; A6NI15; -.
DR TreeFam; TF325707; -.
DR PathwayCommons; A6NI15; -.
DR SignaLink; A6NI15; -.
DR BioGRID-ORCS; 343930; 1 hit in 1081 CRISPR screens.
DR GenomeRNAi; 343930; -.
DR Pharos; A6NI15; Tbio.
DR PRO; PR:A6NI15; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NI15; protein.
DR Bgee; ENSG00000151379; Expressed in bone marrow cell and 9 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007379; P:segment specification; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040259; Mesogenin/MesP.
DR PANTHER; PTHR20937; PTHR20937; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..193
FT /note="Mesogenin-1"
FT /id="PRO_0000330028"
FT DOMAIN 124..178
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 34..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 80
FT /note="E -> D (in dbSNP:rs34069439)"
FT /id="VAR_061259"
FT VARIANT 104
FT /note="H -> Y (in dbSNP:rs35858730)"
FT /id="VAR_061260"
SQ SEQUENCE 193 AA; 20778 MW; B57034F9C39C84B1 CRC64;
MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA PSLESYSSSP
CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF QPTHLQGGGG PKAQKGTKVR
MSVQRRRKAS EREKLRMRTL ADALHTLRNY LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD
LLNRGREPRA QSA
