ID   MSGN1_XENLA             Reviewed;         173 AA.
AC   Q9W690;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Mesogenin-1;
DE   AltName: Full=MesP-related bHLH factor;
DE   AltName: Full=Paraxial mesoderm-specific expression and regulatory capacities;
DE   AltName: Full=pMesogenin1;
DE            Short=pMsgn1;
GN   Name=msgn1; Synonyms=mespo;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=10354484; DOI=10.1016/s0925-4773(99)00010-6;
RA   Joseph E.M., Cassetta L.A.;
RT   "Mespo: a novel basic helix-loop-helix gene expressed in the presomitic
RT   mesoderm and posterior tailbud of Xenopus embryos.";
RL   Mech. Dev. 82:191-194(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=10837126; DOI=10.1006/dbio.2000.9717;
RA   Yoon J.K., Moon R.T., Wold B.;
RT   "The bHLH class protein pMesogenin1 can specify paraxial mesoderm
RT   phenotypes.";
RL   Dev. Biol. 222:376-391(2000).
CC   -!- FUNCTION: Involved in specifying the paraxial, but not dorsal,
CC       mesoderm. May regulate the expression of T-box transcription factors
CC       required for mesoderm formation and differentiation, such as brachyury
CC       T, wnt8, vegt and eomes. {ECO:0000269|PubMed:10837126}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- DEVELOPMENTAL STAGE: Expressed specifically in presomitic paraxial
CC       mesoderm and its immediate presumptive progenitor cells and sharply
CC       down-regulated in presumptive somites. Expression is first detected at
CC       gastrulation. Expressed throughout development until the tadpole stage.
CC       Expression is predominantly localized in ventrolateral mesoderm but is
CC       absent from dorsal mesoderm in gastrulae. In tailbud stage embryos,
CC       expression is still detected and is localized to the most caudal
CC       (unsegmented) paraxial mesoderm. At the tadpole stage, expression
CC       remains in the tailbud. {ECO:0000269|PubMed:10354484,
CC       ECO:0000269|PubMed:10837126}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF087650; AAD28545.1; -; mRNA.
DR   EMBL; AF261106; AAF70376.1; -; mRNA.
DR   RefSeq; NP_001083813.1; NM_001090344.1.
DR   AlphaFoldDB; Q9W690; -.
DR   SMR; Q9W690; -.
DR   PRIDE; Q9W690; -.
DR   GeneID; 399133; -.
DR   KEGG; xla:399133; -.
DR   CTD; 399133; -.
DR   Xenbase; XB-GENE-972091; msgn1.L.
DR   OMA; SSWDWKN; -.
DR   OrthoDB; 1493381at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 399133; Expressed in neurula embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040259; Mesogenin/MesP.
DR   PANTHER; PTHR20937; PTHR20937; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..173
FT                   /note="Mesogenin-1"
FT                   /id="PRO_0000330032"
FT   DOMAIN          109..163
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          39..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..117
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  19588 MW;  F2BAB878698B308C CRC64;
     METLHHPLVK MEEDYALSSD SEPNSTCMAN TWDWKSHNES YSLSQTPSPQ SVSPAASYES
     TYSSSPHTGQ GLEEMPFSYS LLQYPTLCHG DNGALTKKDH GHKTSMTTHR RRKASEREKL
     RMRAIAEALH TLRNNLPPMY SQGRQPLTKI QTLKCTINYI SELTNLLQCS KRA