ID   MSGN1_XENTR             Reviewed;         172 AA.
AC   Q28C89;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Mesogenin-1;
GN   Name=msgn1; ORFNames=TGas099h21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in specifying the paraxial, but not dorsal,
CC       mesoderm. May regulate the expression of T-box transcription factors
CC       required for mesoderm formation and differentiation, such as brachyury
CC       T, wnt8, vegt and eomes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; CR942397; CAJ83750.1; -; mRNA.
DR   RefSeq; NP_001039104.1; NM_001045639.1.
DR   AlphaFoldDB; Q28C89; -.
DR   SMR; Q28C89; -.
DR   STRING; 8364.ENSXETP00000033971; -.
DR   PaxDb; Q28C89; -.
DR   Ensembl; ENSXETT00000033971; ENSXETP00000033971; ENSXETG00000015571.
DR   GeneID; 733924; -.
DR   KEGG; xtr:733924; -.
DR   CTD; 343930; -.
DR   Xenbase; XB-GENE-972085; msgn1.
DR   eggNOG; KOG4029; Eukaryota.
DR   HOGENOM; CLU_084234_1_1_1; -.
DR   InParanoid; Q28C89; -.
DR   OMA; SSWDWKN; -.
DR   OrthoDB; 1493381at2759; -.
DR   PhylomeDB; Q28C89; -.
DR   TreeFam; TF325707; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015571; Expressed in neurula embryo and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040259; Mesogenin/MesP.
DR   PANTHER; PTHR20937; PTHR20937; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..172
FT                   /note="Mesogenin-1"
FT                   /id="PRO_0000330031"
FT   DOMAIN          108..162
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19621 MW;  B7A6258BAF4ADEF5 CRC64;
     METLHHPLVK MEDDYALSSD SEPNSSCMAS TWDWKNNDER YSLSQTPSPQ SLSPAVSYES
     PYSSSSHTQG LEEMPFSYSL LQYPSLCHGD NGDLTKKDHG HKPSMTVQRR RKASEREKLR
     MRAIAEALHT LRNNLPPMYS QGRQPLTKIQ TLKCTINYIS ELTNLLQCSK RV