ID   MSH1_SCHPO              Reviewed;         941 AA.
AC   O13921; O13700; Q9USD9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=MutS protein homolog 1;
GN   Name=msh1; ORFNames=SPAC13F5.01c, SPAC23C11.18c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 623-792, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
CC   -!- FUNCTION: Involved in mitochondrial DNA repair. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10759889}.
CC       Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB11169.1; -; Genomic_DNA.
DR   EMBL; AB027833; BAA87137.1; -; Genomic_DNA.
DR   PIR; T38256; T37626.
DR   RefSeq; NP_593649.2; NM_001019080.3.
DR   AlphaFoldDB; O13921; -.
DR   SMR; O13921; -.
DR   BioGRID; 279280; 19.
DR   STRING; 4896.SPAC13F5.01c.1; -.
DR   iPTMnet; O13921; -.
DR   MaxQB; O13921; -.
DR   PaxDb; O13921; -.
DR   EnsemblFungi; SPAC13F5.01c.1; SPAC13F5.01c.1:pep; SPAC13F5.01c.
DR   GeneID; 2542833; -.
DR   KEGG; spo:SPAC13F5.01c; -.
DR   PomBase; SPAC13F5.01c; msh1.
DR   VEuPathDB; FungiDB:SPAC13F5.01c; -.
DR   eggNOG; ENOG502QUUG; Eukaryota.
DR   HOGENOM; CLU_002472_4_0_1; -.
DR   InParanoid; O13921; -.
DR   OMA; MQCGDFY; -.
DR   PhylomeDB; O13921; -.
DR   PRO; PR:O13921; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000262; C:mitochondrial chromosome; IC:PomBase.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; ISS:PomBase.
DR   GO; GO:0008094; F:ATP-dependent activity, acting on DNA; ISO:PomBase.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; ISM:PomBase.
DR   GO; GO:0006298; P:mismatch repair; ISM:PomBase.
DR   GO; GO:0043504; P:mitochondrial DNA repair; ISO:PomBase.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA-binding; Mitochondrion;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..941
FT                   /note="MutS protein homolog 1"
FT                   /id="PRO_0000115180"
FT   BINDING         747..754
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   941 AA;  106933 MW;  7A1D8F477E1140AB CRC64;
     MPTWRYIFSL RSKSSFTKTW VPFTQIRNSS KSPKVGQKPI LQGALGPPLD FIRPKEKVTL
     PPLLKEVSFQ QKKFADCVLL TKVGNFYEMY FEQAEKIGPL LNLRVSKKKT SKSDVSMAGF
     PFFKLDRYLK ILVEDLKKCV ALSEEVIRPV DDLSSKNMYI RSVTRVITPG TLIDENFMNP
     YESNYILTVV FDPNFFSSDI SNQGTAEDKD CFADCKIGLS WLDLSTGEFF TQDSNLQRLA
     GDLTRISPRE IVLDESLKSF TTHPIYSFIQ ERKYFLSYVE NRYQSLDCWN KFLEKEIDPS
     FIKYCTKLEV TAGCTLISYI ADRLQNSHPN IQPPIRVSLN EYMIIGESAM KGLEIRSSLY
     QNRYTGSLLH AINKTVTKSG SRLLTRRLCA PSTNIVEINN RLDLVEKFKL LPELCSKVIN
     LLKKSNDTHR ILQHLLMGRG NSYDLLKMAD NFSITKEIHS LLSPLESSSA FRLLLLNMHP
     HDELKQLINN AVDENALMKQ KINEEEETEV IAQEAEEILQ DENAQVEIVK KSLSSEFDIR
     QSFKENWVVK SNFNNNLRKL HEKLQSLFAS YDKLQEDLSK RLGKKATLRK SPAKLYYVHL
     KLSGNETIER FIKKFTQAVL FQSTKSTASF QLPGWTSLGM DLENTKLHIH QEEQRVLKSI
     TDEIVSHHKT LRSLANALDE LDISTSLATL AQEQDFVRPV VDDSHAHTVI QGRHPIVEKG
     LSHKLIPFTP NDCFVGNGNV NIWLITGPNM AGKSTFLRQN AIISILAQIG SFVPASNARI
     GIVDQIFSRI GSADNLYQQK STFMVEMMET SFILKNATRR SFVIMDEIGR GTTASDGIAI
     AYGCLKYLST INHSRTLFAT HAHQLTNLTK SFKNVECYCT NLSIDRDDHT FSFDYKLKKG
     VNYQSHGLKV AEMAGIPKNV LLAAEEVLTL LPNTSKPTSM K