ID   MSH2_MAIZE              Reviewed;         942 AA.
AC   Q9XGC9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MSH2;
DE   AltName: Full=MUS1;
GN   Name=MUS1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Horwath M., Kunze R.;
RT   "Isolation and characterization of mus1, a putative mismatch repair gene of
RT   Zea mays.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in postreplication mismatch repair. Binds
CC       specifically to DNA containing mismatched nucleotides thus providing a
CC       target for the excision repair processes characteristic of
CC       postreplication mismatch repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of MSH2 and MSH6 (GTBP). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AJ238785; CAB42554.1; -; Genomic_DNA.
DR   RefSeq; NP_001146301.1; NM_001152829.1.
DR   AlphaFoldDB; Q9XGC9; -.
DR   SMR; Q9XGC9; -.
DR   STRING; 4577.GRMZM2G056075_P01; -.
DR   PaxDb; Q9XGC9; -.
DR   PRIDE; Q9XGC9; -.
DR   EnsemblPlants; Zm00001eb326520_T001; Zm00001eb326520_P001; Zm00001eb326520.
DR   GeneID; 100279876; -.
DR   Gramene; Zm00001eb326520_T001; Zm00001eb326520_P001; Zm00001eb326520.
DR   KEGG; zma:100279876; -.
DR   eggNOG; KOG0219; Eukaryota.
DR   HOGENOM; CLU_002472_10_0_1; -.
DR   OrthoDB; 138168at2759; -.
DR   Proteomes; UP000007305; Chromosome 7.
DR   ExpressionAtlas; Q9XGC9; baseline and differential.
DR   Genevisible; Q9XGC9; ZM.
DR   GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR032642; Msh2.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF35; PTHR11361:SF35; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..942
FT                   /note="DNA mismatch repair protein MSH2"
FT                   /id="PRO_0000115188"
FT   BINDING         667..674
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   942 AA;  105071 MW;  79B82EB149839C4F CRC64;
     MEGDDFTPEG GKLPEFKLDA RQAQGFISFF KKLPQDPRAV RLFDRRDYYT AHGENATFIA
     RTYYHTMSAL RQLGSSSDGI LSASVSKAMF ETIARNILLE RTDCTLELYE GSGSNWRLTK
     SGTPGNIGSF EDILFANNDM EDSPVIVALF PACRESQLYV GLSFLDMTNR KLGLAEFPED
     SRFTNVESAL VALGCKECLL PADCEKSIDL NPLQDVISNC NVLLTEKKKA DFKSRDLAQD
     LGRIIRGSVE PVRDLLSQFD YALGPLGALL SYAELLADDT NYGNYTIEKY NLNCYMRLDS
     AAVRALNIAE GKTDVNKNFS LFGLMNRTCT VGMGKRLLNR WLKQPLLDVN EINNRLDMVQ
     AFVEDPELRQ GLRQQLKRIS DIDRLTHSLR KKSANLQPVV KLYQSCSRIP YIKGILQQYN
     GQFSTLIRSK FLEPLEEWMA KNRFGRFSSL VETAIDLAQL ENGEYRISPL YSSDLGVLKD
     ELSVVENHIN NLHVDTASDL DLSVDKQLKL EKGSLGHVFR MSKKEEQKVR KKLTGSYLII
     ETRKDGVKFT NSKLKNLSDQ YQALFGEYTS CQKKVVGDVV RVSGTFSEVF ENFAAVLSEL
     DVLQSFADLA TSCPVPYVRP DITASDEGDI VLLGSRHPCL EAQDGVNFIP NDCTLVRGKS
     WFQIITGPNM GGKSTFIRQV GVNVLMAQVG SFVPCDQASI SVRDCIFARV GAGDCQLHGV
     STFMQEMLET ASILKGASDK SLIIIDELGR GTSTYDGFGL AWAICEHLME VTRAPTLFAT
     HFHELTALAH RNDDEHQHIS DIGVANYHVG AHIDPLSRKL TMLYKVEPGA CDQSFGIHVA
     EFANFPEAVV ALAKSKAAEL EDFSTTPTFS DDLKDEVGSK RKRVFSPDDI TRGAARARLF
     LEEFAALPMD EMDGSKILEM ATKMKADLQK DAADNPWLQQ FF