ID   MSH2_NEUCR              Reviewed;         937 AA.
AC   O13396; Q7RVA5;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=DNA mismatch repair protein msh-2;
GN   Name=msh-2; Synonyms=msh2; ORFNames=NCU02230;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=74-OR23-1VA / FGSC 2489;
RA   Huber D.H., Hausner G., Yamamoto K., Ishii C., Seidel-Rogol B.L.,
RA   Bertrand H.;
RT   "Neurospora crassa MSH2, a MutS homolog.";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in post-replicative DNA-mismatch repair. Binds to
CC       mismatch-containing DNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of msh2 and msh6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AF030634; AAB84225.1; -; Genomic_DNA.
DR   EMBL; CM002242; EAA30407.1; -; Genomic_DNA.
DR   RefSeq; XP_959643.1; XM_954550.2.
DR   AlphaFoldDB; O13396; -.
DR   SMR; O13396; -.
DR   STRING; 5141.EFNCRP00000003090; -.
DR   EnsemblFungi; EAA30407; EAA30407; NCU02230.
DR   GeneID; 3875790; -.
DR   KEGG; ncr:NCU02230; -.
DR   VEuPathDB; FungiDB:NCU02230; -.
DR   HOGENOM; CLU_002472_10_0_1; -.
DR   InParanoid; O13396; -.
DR   OMA; LFRIYQV; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR032642; Msh2.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF35; PTHR11361:SF35; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..937
FT                   /note="DNA mismatch repair protein msh-2"
FT                   /id="PRO_0000115189"
FT   BINDING         659..666
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   937 AA;  105069 MW;  BC7AABE137423EB8 CRC64;
     MSSRPELKVD DEHGFIRFYK SLPQLGEEAI RIFDRGDWYT AHGDDATFIA RTVYKTTSVI
     RQLGRSDHTG LPSVTMTVTV FRQFLREALF KLGKRIEIWA SPSGRMNWKV VKQASPGNLQ
     DVEDELGGQF EGAPVILAVK ISAKASEART VGVCFADASV RELGVSEFLD NDLYSNFEAL
     LIQLGVKECI VTQDKGEKEK DPELAKLRQI IDNCGVAIAE RSAGEFGTKD IEQDLSRLLK
     DERAASLLPQ TDLKLAMGSA SALIKYLGIL HDPSNFGQYQ LYQHDLAQFM KLDAAALKAL
     NLMPGARDGA KNMSLYGLLN HCKTPVGSRL LSQWLKQPLM NAEEIEKRQQ LVEAFANDTE
     LRQSMQEEHL RSIPDLYRLS KRFQRGKATL EDVVRAYQVV IRLPGFIGTL EGVMDEAYRD
     PLDEVYTNKL RELSDSLVKL QEMVETTVDL DALDNHEFII KPEFDDSLRI IRKKLDRLRT
     DMDNEFAEAA EDLGQEREKK IFLENHKVHG WCMRLTRTEA GCIRNNSRYL ECSTQKNGVY
     FTTKTLQALR REFDQLSQNY NRTQSSLVNE VVGVAASYCP VLERLAAVLA HLDVIVSFAH
     CSVHAPISYV RPKIHPRGTG RTVLTEARHP CMEVQDDVTF ITNDVTLTRE DSSFLIITGP
     NMGGKSTYIR QIGVIALMAQ IGCFVPCSSA ELTIFDSILA RVGASDSQLK GVSTFMAEML
     ETANILKSAT AESLIIIDEL GRGTSTYDGF GLAWAISEHI VKEIGCFALF ATHFHELTAL
     ADQYPNVKNL HVTAHISGTD TDTDVITDED EKAKKKREVT LLYKVEPGIC DQSFGIHVAE
     LVRFPDKVVR MAKRKADELE DFTSKHEEEN GGGLGVQYSK QDVEEGSALL KDVLVKWKDE
     VKSGRMSKEE MVARLKELVQ KDERLLGNPF FKSVQAL