ID   6PGL_XENNA              Reviewed;         328 AA.
AC   Q9RMP7; D3VAR4;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605};
DE            Short=6-P-gluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605};
DE            EC=3.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01605};
GN   Name=pgl {ECO:0000255|HAMAP-Rule:MF_01605}; OrderedLocusNames=XNC1_1437;
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / CCUG 14189 / LMG
OS   1036 / NCIMB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 / AN6;
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA   Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA   Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA   Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA   Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA   Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA   Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA   van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA   Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA   Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT   convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:E27909-E27909(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 54-328.
RC   STRAIN=ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 / AN6;
RX   PubMed=10742251; DOI=10.1128/aem.66.4.1622-1628.2000;
RA   Volgyi A., Fodor A., Forst S.;
RT   "Inactivation of a novel gene produces a phenotypic variant cell and
RT   affects the symbiotic behavior of Xenorhabdus nematophilus.";
RL   Appl. Environ. Microbiol. 66:1622-1628(2000).
CC   -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC       phosphogluconate. {ECO:0000255|HAMAP-Rule:MF_01605}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01605};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000255|HAMAP-Rule:MF_01605}.
CC   -!- SIMILARITY: Belongs to the cycloisomerase 2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01605}.
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DR   EMBL; FN667742; CBJ89500.1; -; Genomic_DNA.
DR   EMBL; AF191556; AAF04393.1; -; Genomic_DNA.
DR   RefSeq; WP_010848273.1; NC_014228.1.
DR   AlphaFoldDB; Q9RMP7; -.
DR   SMR; Q9RMP7; -.
DR   STRING; 406817.XNC1_1437; -.
DR   EnsemblBacteria; CBJ89500; CBJ89500; XNC1_1437.
DR   KEGG; xne:XNC1_1437; -.
DR   eggNOG; COG2706; Bacteria.
DR   HOGENOM; CLU_038716_2_0_6; -.
DR   OMA; EGNWPRD; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_01605; 6P_gluconolactonase; 1.
DR   InterPro; IPR022528; 6-phosphogluconolactonase_YbhE.
DR   InterPro; IPR019405; Lactonase_7-beta_prop.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF10282; Lactonase; 1.
DR   SUPFAM; SSF50974; SSF50974; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Glucose metabolism; Hydrolase; Reference proteome.
FT   CHAIN           1..328
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000171141"
FT   CONFLICT        227
FT                   /note="W -> C (in Ref. 2; AAF04393)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="E -> G (in Ref. 2; AAF04393)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        265
FT                   /note="A -> T (in Ref. 2; AAF04393)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        273..280
FT                   /note="QPRGFAID -> NPVALPLI (in Ref. 2; AAF04393)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   328 AA;  36600 MW;  9F52F5F67DFADF92 CRC64;
     MKQVVYTASP NSRQIHVWSL NVEGGLSLLQ TVDVPGEVQP MVINPDGKHL YVGIRPQFSI
     VTYAIGKNGS LEQKSIAPLP GSPTHISTDR AGRFLFSASY SFNNLSVHPI DDQGNVKAPI
     QIVENLQAPH SANIDRENRQ LLVPCLKEDH IRIFNMDNQG YLVESHADAI TTETGAGPRH
     MAFHPKKQAI YCINELDSTV DVLRKWEKYR IVQSVDSLPA DFSSVRWSAD IHMTPDGRHL
     YTSERSESLI SHFRVSEEGY HLTLAGHYLT ETQPRGFAID HSGHFLIASG QKSDHISVSR
     IDKFSGELTQ LARYPVGKSP MWVTILAL