ID   MSH4_CANAX              Reviewed;         803 AA.
AC   O94065;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=MutS protein homolog 4;
GN   Name=MSH4; ORFNames=Ca49C4.07c;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1161;
RA   Murphy L., Harris D., Barrell B.G., Rajandream M.A.;
RT   "Candida albicans strain 1161 genome pilot sequencing project.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in meiotic recombination. Facilitate crossovers
CC       between homologs during meiosis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomer of MSH4 and MSH5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AL033503; CAA22017.1; -; Genomic_DNA.
DR   PIR; T18246; T18246.
DR   AlphaFoldDB; O94065; -.
DR   SMR; O94065; -.
DR   VEuPathDB; FungiDB:CAWG_01530; -.
DR   VEuPathDB; FungiDB:CR_01790C_A; -.
DR   GO; GO:0062128; C:MutSgamma complex; IEA:EnsemblFungi.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0062037; F:D-loop DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0000403; F:Y-form DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IEA:EnsemblFungi.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Meiosis; Nucleotide-binding.
FT   CHAIN           1..803
FT                   /note="MutS protein homolog 4"
FT                   /id="PRO_0000115200"
FT   BINDING         557..564
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   803 AA;  90800 MW;  122DDCFBF7A47209 CRC64;
     MALASQLSVT DDSAYGFITT NAEIVSKKRK LAQNDDRFEV VMSVYSPKAD SMDVGVSVLK
     LKTLELTLMS FCDSSTFVRT VNQIQVYEPT SIILPEAQSH SQIEKLKYII HSNISDKVRE
     RFMKAKVFNA FDGMNSLKLY TDINESTLGQ VISNRKLSLA AANACIDYCV STKMFRVTNK
     IRLKYCMCEN TMLIDTCTVR DLELVDSLSE TGTTLYSFLN CCLTKMGMRI LRTSILQPST
     HENSIILRSE SLQELINDED ALISIRSSLK HTCDLEKVFS TFLEPRGLLS QEQEINNIIL
     LKTVLQNTFV IRKSIQNVSS HLLVQVKQIL EHENVQHLLA IINEYIRNDC QWANNSTELA
     NQRANAVKSG VNGLLDVSRR IRETLLEEVS ELVAKLSEEL EIFMEYRFEI SRGFFIKIKG
     NNTDINSLPE VLINRVKKRK TIECTTIELM KQSSRYNDIV SEITTLNSTI IHDMYTSINS
     YTPILLMVSE AIGTLDLLCS FAYFTSLQKD SYTCPEFAKE VTIMRSLHPI LGGNNSNFVA
     NNYSCNHELS RIHVITGANM SGKSVYLRQI AYLVIMAQMG CFVPAEYARM RIFNSLYSRI
     SSDNVDINAS SFSKEMSETA VILNDSDGDS LILIDELGRG SSLTDGFSIC LAILEDLICK
     EATVITTTHF RDIAQVLANK SCVVTAHMQT VETNGQLEMK YNLVLGRNDI VGYGIRFAEV
     SNLLPQELIE DSKVVANILR SRKPVHGDKE LKLLSRRRKL VLELYFALNY ISKLNCDMNY
     KMQLLQTLQS KFVEEINITP NTE