ID   MSH5_RAT                Reviewed;         831 AA.
AC   Q6MG62; Q5XHZ5;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=MutS protein homolog 5;
GN   Name=Msh5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in DNA mismatch repair and meiotic recombination
CC       processes. Facilitates crossovers between homologs during meiosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; BX883045; CAE83984.1; -; Genomic_DNA.
DR   EMBL; BC083904; AAH83904.1; -; mRNA.
DR   RefSeq; NP_997701.2; NM_212536.2.
DR   RefSeq; XP_017457063.1; XM_017601574.1.
DR   AlphaFoldDB; Q6MG62; -.
DR   SMR; Q6MG62; -.
DR   STRING; 10116.ENSRNOP00000057489; -.
DR   iPTMnet; Q6MG62; -.
DR   PhosphoSitePlus; Q6MG62; -.
DR   PaxDb; Q6MG62; -.
DR   PRIDE; Q6MG62; -.
DR   Ensembl; ENSRNOT00000060762; ENSRNOP00000057489; ENSRNOG00000000857.
DR   GeneID; 294252; -.
DR   KEGG; rno:294252; -.
DR   UCSC; RGD:1303008; rat.
DR   CTD; 4439; -.
DR   RGD; 1303008; Msh5.
DR   eggNOG; KOG0221; Eukaryota.
DR   GeneTree; ENSGT00550000074977; -.
DR   HOGENOM; CLU_002472_8_0_1; -.
DR   InParanoid; Q6MG62; -.
DR   OMA; VIEYTAH; -.
DR   OrthoDB; 138168at2759; -.
DR   PhylomeDB; Q6MG62; -.
DR   TreeFam; TF314549; -.
DR   PRO; PR:Q6MG62; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000857; Expressed in testis and 14 other tissues.
DR   ExpressionAtlas; Q6MG62; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000795; C:synaptonemal complex; ISO:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0051026; P:chiasma assembly; IBA:GO_Central.
DR   GO; GO:0007292; P:female gamete generation; ISO:RGD.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISO:RGD.
DR   GO; GO:0007127; P:meiosis I; ISO:RGD.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Meiosis;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..831
FT                   /note="MutS protein homolog 5"
FT                   /id="PRO_0000115204"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         589..596
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        379
FT                   /note="Missing (in Ref. 2; AAH83904)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   831 AA;  92452 MW;  6C6AE6C02795321D CRC64;
     MAFRATPGRT PPGPGPGVPS ASFSSPQPAM AAPGGIEEED EEEPAEIHLC VLWSSGYLGI
     AYYDTSDSTI HFMPDAPDHE SLKLLQRVLD EINPQSVVTS AKQDEAMTQF LGKLASQEHR
     EPKRPEIILL PSVDFGPEIS KQRLLSGNYS FISESMTATE KILFLSSIIP FDCVLTVRAL
     GGLLKFLSRR RVGVELEDYS VGVPILGFKK FVLTHLVSID QDTYSVLQIF KSESHPSVYK
     VASGLKEGLS LFGILNRCRC RWGQKLLRLW FTRPTRELRE LNSRLDVIEF FLMPQNLDMA
     QMMHRLLSHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA LGLRDACRSL PQSIQLFRDI
     TQEFSDDLHH IASLIGKVVD FEESLAENRF TVLPNIDPEI DAKKRRLMGL PSFLTEVAQK
     ELENLDSCIP SCSVIYIPLI GFLLSIPRLS FMVEASDFEI EGLDFMFLSE DKLHYRSART
     KELDALLGDL HCEIRDQEML LMHQLQCQVL ARAPVLTRVL DLASRLDVLL ALASAARDYG
     YSRPHYSPCI QGVRIKNGRH PLMELCARTF VPNSTDCGGD QGRVKVITGP NSSGKSIYLK
     QVGLITFMAL VGSFVPAEEA EIGVIDAIFT RIHSCESISL GLSTFMIDLN QVAKAVNNAT
     EHSLVLIDEF GKGTNSVDGL ALLTAVLRHW LALGPSCPHI FVATNFLSLV QLQLLPQGPL
     VQYLTMETCE DGNDLVFFYQ LCHGVASASH ASYTAAQAGL PDPLIARGKE VSDSIRSGKP
     VKPMHELVRR TQMENCQALV DKFLKLDLED PSLDLDIFIS QEVLPAATTI L