ID   MSHM_SARGL              Reviewed;         982 AA.
AC   O63852;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mitochondrial DNA mismatch repair protein mutS homolog;
OS   Sarcophyton glaucum (Toadstool umbrella leather coral).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Octocorallia; Alcyonacea;
OC   Alcyoniina; Alcyoniidae; Sarcophyton.
OX   NCBI_TaxID=70919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9541536; DOI=10.1007/pl00006321;
RA   Pont-Kingdon G., Okada N.A., Macfarlane J.L., Beagley C.T.,
RA   Watkins-Sims C.D., Cavalier-Smith T., Clark-Walker G.D., Wolstenholme D.R.;
RT   "Mitochondrial DNA of the coral Sarcophyton glaucum contains a gene for a
RT   homologue of bacterial MutS: a possible case of gene transfer from the
RT   nucleus to the mitochondrion.";
RL   J. Mol. Evol. 46:419-431(1998).
CC   -!- FUNCTION: May be involved in DNA-mismatch repair.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AF063191; AAC16386.1; -; Genomic_DNA.
DR   PIR; S58881; S58881.
DR   AlphaFoldDB; O63852; -.
DR   SMR; O63852; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01844; HNH; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00507; HNHc; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Mitochondrion;
KW   Nucleotide-binding.
FT   CHAIN           1..982
FT                   /note="Mitochondrial DNA mismatch repair protein mutS
FT                   homolog"
FT                   /id="PRO_0000115214"
FT   DOMAIN          905..951
FT                   /note="HNH"
FT   BINDING         698..705
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   982 AA;  111912 MW;  A3F107319BC0E023 CRC64;
     MNQIPMQYFN LAKENYSKYG LSVIQLIQIG KFYELWHEPD TSSKQQAYSQ AELLVESSIR
     SRSLEVTPPI EQVASLLDMK IISLGKRSLL QMGFPVYSLT THLSTLLDKG WTVIVIDELV
     TNKSGPKQRA VSQVYSPSCN LEDCPELPYV LSIYFSQDDL LGITLFSAMN GHSIIFPVSW
     TDRDKVTRLL ISYHIREIVI WADSGVCSNI LINKIYNLLI GWNLFPSEPN AKIEAMGEIL
     TNLPCYLSYR YENNSKEWLL LHIYIGINTE WLNKNYQKYT LSKIFQSTWT ENVNQANLIS
     LLGVLQFIKD RNPNLIKNLQ LPECYNSVVS PLNLILCNRA EYQLDLLSKR GKLGGLLNLI
     DYCSTAMGKR LLKFRLLNPI TDYSELNLRY KDISIFKRLL NQKIFDNSEL KCIKDLSSLH
     RQWAICASSD TTLPPKKLSQ IYHSYLFACQ LISKLTNNIQ LPPLVGPQLK SLIKEIERIF
     QVDSLLGDFK DVIQPIGNLP NLFEQRQTLR AQLTEWAEQI SNIVFQDTTS IKAEYFNKEG
     YAFSISSKKL TKLEHYMMNT SISNNSIIVL GKRGSHHIIT SPTIHKVSIE LNELEEQINI
     YVKQTYHQEL KRLYFSYSEL FLPLVNMISR LDVALSGAIT AIKFNYVEPC LTLAKTQQTK
     GFIEAANLRH PLVEQLNTQE ECIAHNISLE DKGMLVFSVN GAGKSTLLRA IGVNVILAQA
     GMYVAADSFK LRPYNYLITR ILGGDDLYRG QGTFEVEMRD LSTILQLANY NSLILGDEIC
     HGTEVNSGTA ILAATIERLI NAQTSFVLST HLHQVCSLID SPVRYYHLSV IQQENSALIY
     ERKLKPGPGP SQYGIEVMGH IINDKKFYNS ALKYRKLINW EPPSQGELTV FRPSKYNAQV
     FIDSCEICGA PADAVHHIKP KSEHKKLCNR KLNRRSNLVP VCSSCHLDIH RNKISILGWK
     RTPKHKKLYW VYTNESLDSG TK