MSHR_PIG
ID MSHR_PIG Reviewed; 320 AA.
AC Q9TU05; Q2M499; Q2M4A0; Q2M4A3; Q6QZW6; Q9TV86; Q9TV87; Q9TV88; Q9XS81;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 3.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Melanocyte-stimulating hormone receptor;
DE Short=MSH-R;
DE AltName: Full=Melanocortin receptor 1;
DE Short=MC1-R;
GN Name=MC1R;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-95; PRO-102; MET-192
RP AND VAL-213.
RC STRAIN=Jeju native black; TISSUE=Blood;
RA Cho I.C., Jung J.K., Jung Y.H., Jeon J.T.;
RT "The complete sequence of pig (Sus scrofa) MC1R gene.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-95; VAL-164 AND
RP THR-243.
RA Shi K., Wang A., Li N.;
RT "Single nucleotide polymorphisms (SNPs) analysis on the extension (MC1R),
RT the white (KIT) and the agouti (ASIP) loci and their association with coat
RT color phenotypes of pigs.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-313, FUNCTION, AND VARIANTS MC1R*1;
RP MC1R*2; MC1R*3 AND MC1R*4.
RX PubMed=9799269; DOI=10.1093/genetics/150.3.1177;
RA Kijas J.M.H., Wales R., Tornsten A., Chardon P., Moller M., Andersson L.;
RT "Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.";
RL Genetics 150:1177-1185(1998).
CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH (By
CC similarity). The activity of this receptor is mediated by G proteins
CC which activate adenylate cyclase (By similarity). Mediates
CC melanogenesis, the production of eumelanin (black/brown) and
CC phaeomelanin (red/yellow), via regulation of cAMP signaling in
CC melanocytes (PubMed:9799269). {ECO:0000250|UniProtKB:Q01726,
CC ECO:0000269|PubMed:9799269}.
CC -!- SUBUNIT: Interacts with MGRN1, but does not undergo MGRN1-mediated
CC ubiquitination; this interaction competes with GNAS-binding and thus
CC inhibits agonist-induced cAMP production. Interacts with OPN3; the
CC interaction results in a decrease in MC1R-mediated cAMP signaling and
CC ultimately a decrease in melanin production in melanocytes.
CC {ECO:0000250|UniProtKB:Q01726}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01726};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- POLYMORPHISM: Variation is correlated with coat color. MC1R*2 is
CC associated with the black color of European large black and Chinese
CC meishan pigs. MC1R*3 is associated with the black color in the
CC hampshire breed. MC1R*4 is found in recessive red animals.
CC {ECO:0000269|PubMed:9799269}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY520823; AAS17973.1; -; Genomic_DNA.
DR EMBL; AF181964; AAD53963.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY916520; AAX18256.1; -; Genomic_DNA.
DR EMBL; AY916523; AAX18259.1; -; Genomic_DNA.
DR EMBL; AY916524; AAX18260.1; -; Genomic_DNA.
DR EMBL; AF082487; AAD14569.1; -; Genomic_DNA.
DR EMBL; AF082488; AAD14570.1; -; Genomic_DNA.
DR EMBL; AF082489; AAD14571.1; -; Genomic_DNA.
DR EMBL; AF082490; AAD14572.1; -; Genomic_DNA.
DR RefSeq; NP_001008690.1; NM_001008690.1.
DR AlphaFoldDB; Q9TU05; -.
DR SMR; Q9TU05; -.
DR STRING; 9823.ENSSSCP00000027395; -.
DR PaxDb; Q9TU05; -.
DR GeneID; 494018; -.
DR KEGG; ssc:494018; -.
DR CTD; 4157; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9TU05; -.
DR OrthoDB; 981062at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR InterPro; IPR000761; MSH_rcpt.
DR PANTHER; PTHR22750:SF2; PTHR22750:SF2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00536; MELNOCYTESHR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..320
FT /note="Melanocyte-stimulating hormone receptor"
FT /id="PRO_0000069840"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 95
FT /note="V -> M (in allele MC1R*2 and strain Jeju native
FT black)"
FT /evidence="ECO:0000269|Ref.1, ECO:0000269|Ref.2"
FT VARIANT 102
FT /note="L -> P (in allele MC1R*2 and strain Jeju native
FT black; may form a constitutively active receptor)"
FT /evidence="ECO:0000269|Ref.1"
FT VARIANT 124
FT /note="D -> N (in allele MC1R*3)"
FT VARIANT 164
FT /note="A -> V (in allele MC1R*4)"
FT /evidence="ECO:0000269|Ref.2"
FT VARIANT 192
FT /note="L -> M (in strain: Jeju native black)"
FT /evidence="ECO:0000269|Ref.1"
FT VARIANT 213
FT /note="M -> V (in strain: Jeju native black)"
FT /evidence="ECO:0000269|Ref.1"
FT VARIANT 243
FT /note="A -> T (in allele MC1R*4)"
FT /evidence="ECO:0000269|Ref.2"
SQ SEQUENCE 320 AA; 34592 MW; 90D6B380078739FA CRC64;
MPVLGPERRL LASLSSAPPA APRLGLAANQ TNQTGPQCLE VSIPDGLFLS LGLVSLVENV
LVVAAIAKNR NLHSPMYYFV CCLAVSDLLV SVSNVLETAV LLLLEAGALA AQAAVVQQLD
NVMDVLICGS MVSSLCFLGA IAVDRYVSIF YALRYHSIVT LPRAGRAIAA IWAGSVLSST
LFIAYYHHTA VLLGLVSFFV AMLALMAVLY VHMLARACQH GRHIARLHKT QHPTRQGCGL
KGAATLTILL GVFLLCWAPF FLHLSLVVLC PQHPTCGCVF KNVNLFLALV ICNSIVDPLI
YAFRSQELRK TLQEVLQCSW
