MSI1H_RAT
ID MSI1H_RAT Reviewed; 362 AA.
AC Q8K3P4;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=RNA-binding protein Musashi homolog 1;
DE Short=Musashi-1;
GN Name=Msi1; Synonyms=Msi1h;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RA Kayahara T., Sawada M., Takaishi S., Okano H., Chiba T.;
RT "The expression of Musashi-1 in rat small intestine.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=12205668; DOI=10.1002/jnr.10342;
RA Yagita Y., Kitagawa K., Sasaki T., Miyata T., Okano H., Hori M.,
RA Matsumoto M.;
RT "Differential expression of Musashi1 and nestin in the adult rat
RT hippocampus after ischemia.";
RL J. Neurosci. Res. 69:750-756(2002).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16554442; DOI=10.1242/jcs.02852;
RA Ratti A., Fallini C., Cova L., Fantozzi R., Calzarossa C., Zennaro E.,
RA Pascale A., Quattrone A., Silani V.;
RT "A role for the ELAV RNA-binding proteins in neural stem cells:
RT stabilization of Msi1 mRNA.";
RL J. Cell Sci. 119:1442-1452(2006).
CC -!- FUNCTION: RNA binding protein that regulates the expression of target
CC mRNAs at the translation level. Regulates expression of the NOTCH1
CC antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-
CC 3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May
CC play a role in the proliferation and maintenance of stem cells in the
CC central nervous system (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12205668,
CC ECO:0000269|PubMed:16554442}. Nucleus {ECO:0000269|PubMed:12205668}.
CC -!- TISSUE SPECIFICITY: Expressed in stem and progenitor cells in the
CC subventricular zone of the hippocampus (at protein level)
CC (PubMed:16554442). Detected throughout the hippocampus
CC (PubMed:12205668). Detected in astrocytes, ependymal cells and in the
CC anterior subventricular zone. Detected in proliferating cells
CC (PubMed:12205668). {ECO:0000269|PubMed:12205668,
CC ECO:0000269|PubMed:16554442}.
CC -!- INDUCTION: Up-regulated in the CA1 region of the hippocampus after
CC ischemia. {ECO:0000269|PubMed:12205668}.
CC -!- DOMAIN: The first RNA recognition motif binds more strongly to RNA
CC compared to the second one. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Musashi family. {ECO:0000305}.
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DR EMBL; AY043393; AAK94485.1; -; mRNA.
DR RefSeq; NP_683688.1; NM_148890.1.
DR AlphaFoldDB; Q8K3P4; -.
DR SMR; Q8K3P4; -.
DR STRING; 10116.ENSRNOP00000001532; -.
DR PhosphoSitePlus; Q8K3P4; -.
DR jPOST; Q8K3P4; -.
DR PaxDb; Q8K3P4; -.
DR PRIDE; Q8K3P4; -.
DR Ensembl; ENSRNOT00000001532; ENSRNOP00000001532; ENSRNOG00000001156.
DR GeneID; 259272; -.
DR KEGG; rno:259272; -.
DR CTD; 4440; -.
DR RGD; 628778; Msi1.
DR eggNOG; KOG4205; Eukaryota.
DR GeneTree; ENSGT00940000156515; -.
DR InParanoid; Q8K3P4; -.
DR OrthoDB; 1565323at2759; -.
DR PhylomeDB; Q8K3P4; -.
DR PRO; PR:Q8K3P4; -.
DR Proteomes; UP000002494; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005844; C:polysome; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0008266; F:poly(U) RNA binding; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; NAS:RGD.
DR GO; GO:0003727; F:single-stranded RNA binding; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IEP:RGD.
DR GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR GO; GO:0009725; P:response to hormone; IMP:RGD.
DR CDD; cd12576; RRM1_MSI; 1.
DR CDD; cd12323; RRM2_MSI; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034130; MSI_RRM1.
DR InterPro; IPR034126; MSI_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; RNA-binding.
FT CHAIN 1..362
FT /note="RNA-binding protein Musashi homolog 1"
FT /id="PRO_0000081651"
FT DOMAIN 20..110
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 109..186
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:O43347"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43347"
SQ SEQUENCE 362 AA; 39134 MW; 809316BB384FB747 CRC64;
METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS
RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT
TVEDVKHYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE
CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT
YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST
PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG
YH
