ID   MSL1_DANRE              Reviewed;         489 AA.
AC   A9JRX0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Male-specific lethal 1-like 1;
DE            Short=MSL1-like 1;
DE   AltName: Full=Male-specific lethal-1 homolog 1;
DE            Short=MSL-1;
GN   Name=msl1l1; ORFNames=zgc:175094;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of histone acetyltransferase complex. Within MSL
CC       complex, promotes ubiquitination of histone H2B.
CC       {ECO:0000250|UniProtKB:Q68DK7}.
CC   -!- SUBUNIT: Component of a multisubunit histone acetyltransferase complex
CC       (MSL). {ECO:0000250|UniProtKB:Q68DK7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q68DK7}. Nucleus,
CC       nucleoplasm {ECO:0000250|UniProtKB:Q6PDM1}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q6PDM1}.
CC   -!- SIMILARITY: Belongs to the msl-1 family. {ECO:0000305}.
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DR   EMBL; BC155827; AAI55828.1; -; mRNA.
DR   RefSeq; NP_001107940.1; NM_001114468.1.
DR   AlphaFoldDB; A9JRX0; -.
DR   SMR; A9JRX0; -.
DR   STRING; 7955.ENSDARP00000101527; -.
DR   PaxDb; A9JRX0; -.
DR   PRIDE; A9JRX0; -.
DR   GeneID; 100000715; -.
DR   KEGG; dre:100000715; -.
DR   CTD; 100000715; -.
DR   ZFIN; ZDB-GENE-030131-8168; msl1a.
DR   eggNOG; ENOG502QQ0S; Eukaryota.
DR   InParanoid; A9JRX0; -.
DR   OrthoDB; 560559at2759; -.
DR   PhylomeDB; A9JRX0; -.
DR   PRO; PR:A9JRX0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0072487; C:MSL complex; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR   InterPro; IPR026711; Msl-1.
DR   InterPro; IPR031840; MSL1_dimer.
DR   InterPro; IPR029332; PEHE_dom.
DR   PANTHER; PTHR21656; PTHR21656; 2.
DR   Pfam; PF16801; MSL1_dimer; 1.
DR   Pfam; PF15275; PEHE; 1.
DR   SMART; SM01300; PEHE; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..489
FT                   /note="Male-specific lethal 1-like 1"
FT                   /id="PRO_0000349238"
FT   REGION          126..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          179..227
FT                   /evidence="ECO:0000255"
FT   MOTIF           380..394
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PDM1"
FT   COMPBIAS        249..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  55880 MW;  611877E522585310 CRC64;
     MTLRSIVIKS GGHRLDTSLI KKPAEINEYL ASLKKETCDF ATYVLCSICN SIIQKHQVQS
     KAKISCRKVL SCPDQSSAGG LGHKNWEPSG ALILPSTKQM GAEGSPVKSR SLFCQTNHNH
     LVNMDPMVSN DNNQQREGEQ VGAMVGDSSP EDSPSGKHWN VRKGSGLVDP QTSCIRQILL
     LQLELIEQQQ KHLHNKNKEI EDLKAEKEML MARIERMEHR LQMVKKDGVV SRPSQTTCHK
     EPEAETTTSD DVQHSGGRVQ TPKQTQRGRG VKGSKGKFLL QDSPTGRSRR GQPRSPPTSQ
     QESPALKEDM QCHSKEVPYL TTTEMYLSHW QTPPSPQRDP STVHENTVEV PSWRESILEP
     LGQKEASDIL ECLDDSVFLK RHSKLELDEK RRKRWDIQRI REQRMFQRLQ QRMNRRKVIQ
     ESEPELLSFH AEPEDVEYIM VTPFLPVVAF GSPLPNLKQQ DFDLPWLDER SRCQPEVTKK
     RTPRRRCRK