ID   MSL3_DROVI              Reviewed;         543 AA.
AC   Q9NBL2;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Protein male-specific lethal-3;
GN   Name=msl-3;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10908644; DOI=10.1093/oxfordjournals.molbev.a026407;
RA   Marin I., Baker B.S.;
RT   "Origin and evolution of the regulatory gene male-specific lethal-3.";
RL   Mol. Biol. Evol. 17:1240-1250(2000).
CC   -!- FUNCTION: The MSL proteins are essential for elevating transcription of
CC       the single X chromosome in the male (X chromosome dosage compensation).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
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DR   EMBL; AF247726; AAF88149.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NBL2; -.
DR   SMR; Q9NBL2; -.
DR   GO; GO:0010369; C:chromocenter; IEA:EnsemblMetazoa.
DR   GO; GO:0072487; C:MSL complex; IEA:EnsemblMetazoa.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0000805; C:X chromosome; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0035064; F:methylated histone binding; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007549; P:dosage compensation; ISS:UniProtKB.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.274.30; -; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR008676; MRG.
DR   InterPro; IPR038217; MRG_C_sf.
DR   InterPro; IPR026541; MRG_dom.
DR   PANTHER; PTHR10880; PTHR10880; 2.
DR   Pfam; PF05712; MRG; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS51640; MRG; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..543
FT                   /note="Protein male-specific lethal-3"
FT                   /id="PRO_0000080246"
FT   DOMAIN          10..90
FT                   /note="Chromo"
FT   DOMAIN          249..542
FT                   /note="MRG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00972"
FT   REGION          93..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  62126 MW;  7383FBBACE93A37A CRC64;
     MTAHENEVQL FNRGEKVLCY EPDESKARVL YDSKVLAVYE RKDAANLRYF DYKIHFQGWN
     SSWDRNVRAA SLLKDNEENR KLQRELAEAA QLQKTGGYSY KDSKTPTLPS SKKKRLARGG
     HVEDPTADPL DISLPSSKKK RLARGGHVED PTADPLDISL AHLPATPKPE LPAQQKRGAR
     SRDGSGNRSR DGSGNRSRDN SSGRKKQRDK SKGGDKNDDG ERRSARSQFS LHVSPKDTHT
     TDAEKRIHQE DRVMLRISER LREYMEYDYN MVCKLEKQHA LPARTPIVTI LENFVKQRAV
     ELAIGIKQDS SRARNTLSRN ARMEREYDRV MSIVCMLKEV VDGLRIYFEF HLEDHLLYRE
     EKDYALGFLT DNNMKNCSLL LNKSYEFINP SGDNELISMA GNVNGTNGVD GPLLGDIEYE
     NQLQKCLRYI EKNSAKNNIA LAYTAAYKLP MEMRGFLRET FSWSLLSEES PPEKSIIFGA
     PHLARMLVLL PECLNASPIS NEKLVDLLPH LDSFINYLEN HKEWFDKQNY LDPLIDQGRE
     LSV