MSLNL_HUMAN
ID MSLNL_HUMAN Reviewed; 702 AA.
AC Q96KJ4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Mesothelin-like protein;
DE AltName: Full=Pre-pro-megakaryocyte-potentiating-factor-like;
DE Flags: Precursor;
GN Name=MSLNL; Synonyms=C16orf37, MPFL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in cellular adhesion. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mesothelin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61254.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305};
CC Sequence=EAW85717.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305};
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DR EMBL; AL031258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE006464; AAK61254.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471112; EAW85717.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q96KJ4; -.
DR STRING; 9606.ENSP00000441381; -.
DR GlyGen; Q96KJ4; 3 sites.
DR iPTMnet; Q96KJ4; -.
DR PhosphoSitePlus; Q96KJ4; -.
DR BioMuta; MSLNL; -.
DR DMDM; 313104212; -.
DR PeptideAtlas; Q96KJ4; -.
DR PRIDE; Q96KJ4; -.
DR Ensembl; ENST00000442466.1; ENSP00000415767.1; ENSG00000162006.9.
DR UCSC; uc059osa.1; human.
DR GeneCards; MSLNL; -.
DR HGNC; HGNC:14170; MSLNL.
DR HPA; ENSG00000162006; Not detected.
DR neXtProt; NX_Q96KJ4; -.
DR OpenTargets; ENSG00000162006; -.
DR PharmGKB; PA162396252; -.
DR VEuPathDB; HostDB:ENSG00000162006; -.
DR eggNOG; ENOG502QRX1; Eukaryota.
DR GeneTree; ENSGT00950000182957; -.
DR HOGENOM; CLU_014552_2_0_1; -.
DR InParanoid; Q96KJ4; -.
DR OMA; QAWQLSC; -.
DR PhylomeDB; Q96KJ4; -.
DR TreeFam; TF331713; -.
DR SignaLink; Q96KJ4; -.
DR ChiTaRS; MSLNL; human.
DR Pharos; Q96KJ4; Tdark.
DR PRO; PR:Q96KJ4; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96KJ4; protein.
DR Bgee; ENSG00000162006; Expressed in right uterine tube and 41 other tissues.
DR ExpressionAtlas; Q96KJ4; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR InterPro; IPR010335; Mesothelin.
DR InterPro; IPR026672; Mesothelin-like_protein.
DR InterPro; IPR026664; Stereocilin-rel.
DR PANTHER; PTHR23412; PTHR23412; 1.
DR PANTHER; PTHR23412:SF15; PTHR23412:SF15; 1.
DR Pfam; PF06060; Mesothelin; 1.
PE 3: Inferred from homology;
KW Cell adhesion; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..702
FT /note="Mesothelin-like protein"
FT /id="PRO_0000320648"
FT TOPO_DOM 36..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..668
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 669..702
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 588..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 463
FT /note="D -> V (in dbSNP:rs12599363)"
FT /id="VAR_039257"
FT VARIANT 597
FT /note="S -> G (in dbSNP:rs9746539)"
FT /id="VAR_039258"
FT CONFLICT 168
FT /note="G -> R (in Ref. 2; AAK61254 and 3; EAW85717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 702 AA; 74540 MW; 6D69477B30342C3C CRC64;
MAAAVTIPGP RIGALQSSGL TLLLSLAAHC SGPQAKVLSP GGLDASGANL WASANCSLLQ
GFWCQPASQL PRDQLSALIQ RLALLQVPLQ AWQLSCLANL ASRCGLQDDF TLHPPNLLLF
YNLSQVREAD CRAFIRRAAQ GDVELLSHLP DQRVALWRAA VACLVGAGLR LSASDQQLLG
ALVCDMDASS IGAADPHMLE NLRRCPRLTA AQRIALNSLL AGGKTSLGPP GSWTLEGLQA
LGPLATYISP HLWAQVQEAV GLGFFRSVVA SCQVGRLGQR EARCFVTSFL ESKTKPVSSR
PRLSTGNITA ATLRDDLFLV HYDCAELESC LDGCILRTNL DTLLQHLLPT ECQHVVKAKL
AQIYPQGLPE DQLRLITSLV YLYSRTEIGQ WSITSQDTVM ALLASDVALE NQTEAVLQKF
LEHNGTVSGA LLLAIGGTRL CWMSPHQIQT IHPQELRLAG ALDLSSCPQS RKDVLYTKAH
ETFGSSGTLA AYYRLMRPYL GGSPGGAQPP SPVPPGGAPV EELRHLAHAN ISMDIDTFTS
LNPLELQSLD VGNVTALLGH NVGDLQKARS HPTVRAWLRS LNSSTLGQLG LDASPTSPTG
PAHGTRGPPS TTHQVLHLVH TSGLPTNDAQ ASTSGSLWAP LGYLPLAMAL PCSLLCLLHW
GTCILVSVDS VASGWLGSQG SGAGKTEVLD SAGRPLGLTG QL
