MSLNL_MOUSE
ID MSLNL_MOUSE Reviewed; 685 AA.
AC Q8C160;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Mesothelin-like protein;
DE AltName: Full=Pre-pro-megakaryocyte-potentiating-factor-like;
DE Flags: Precursor;
GN Name=Mslnl; Synonyms=Mpfl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in cellular adhesion. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mesothelin family. {ECO:0000305}.
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DR EMBL; AK028891; BAC26178.1; -; mRNA.
DR EMBL; BC052484; AAH52484.1; -; mRNA.
DR CCDS; CCDS28525.1; -.
DR RefSeq; NP_808490.1; NM_177822.3.
DR RefSeq; XP_006524491.1; XM_006524428.3.
DR AlphaFoldDB; Q8C160; -.
DR STRING; 10090.ENSMUSP00000049020; -.
DR GlyGen; Q8C160; 2 sites.
DR iPTMnet; Q8C160; -.
DR PhosphoSitePlus; Q8C160; -.
DR PaxDb; Q8C160; -.
DR PRIDE; Q8C160; -.
DR ProteomicsDB; 295596; -.
DR DNASU; 328783; -.
DR Ensembl; ENSMUST00000047098; ENSMUSP00000049020; ENSMUSG00000041062.
DR GeneID; 328783; -.
DR KEGG; mmu:328783; -.
DR UCSC; uc008bbn.1; mouse.
DR CTD; 401827; -.
DR MGI; MGI:3607710; Mslnl.
DR VEuPathDB; HostDB:ENSMUSG00000041062; -.
DR eggNOG; ENOG502QRX1; Eukaryota.
DR GeneTree; ENSGT00950000182957; -.
DR HOGENOM; CLU_014552_2_0_1; -.
DR InParanoid; Q8C160; -.
DR OMA; QAWQLSC; -.
DR OrthoDB; 459771at2759; -.
DR PhylomeDB; Q8C160; -.
DR TreeFam; TF331713; -.
DR BioGRID-ORCS; 328783; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8C160; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C160; protein.
DR Bgee; ENSMUSG00000041062; Expressed in morula and 20 other tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR InterPro; IPR010335; Mesothelin.
DR InterPro; IPR026672; Mesothelin-like_protein.
DR InterPro; IPR026664; Stereocilin-rel.
DR PANTHER; PTHR23412; PTHR23412; 1.
DR PANTHER; PTHR23412:SF15; PTHR23412:SF15; 1.
DR Pfam; PF06060; Mesothelin; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..685
FT /note="Mesothelin-like protein"
FT /id="PRO_0000320649"
FT TOPO_DOM 33..627
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 649..685
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 603..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 685 AA; 74710 MW; CABD4B316C53DAB8 CRC64;
MSRTLRPSAM GSRVGALASP GLALLLSLTA HCSGPQAKGL PKGGLNASEA NTWVRNNTSL
LQNFWCLPAS QLPREQLSSL IRSLASQRVA LKAWQLSCLA NLAAQLGLQD DFEFHPPNLL
LFYDLSQVGD TNCRAFIHHA AQGDTELLTN LPNQRVALQR TALACLGGPH LQLSASDLWL
LGVLVCDMEA AQIVTADPSV LRNLLRCPRL TVMQTAALNT LLASGKTQIG PPGSWNLQGL
QALGLLATYI SPHLWEKVQE AVGLDFFRSV VAACRAGQLS RHDARRFVDN FLESKATSVS
SRPKRRTGRS CVRGNITAAT LHDDLFLVHY DCTQLESCLG TRVLRANLDP LLQHPLPAEC
QRVVKAKLTQ IYPHGIPEDQ LHLIPSLVYL YSLAEIGQWN ITSGDTVMIL LASDAALDNQ
TEAVLQRFLD HNGKVTGALL VAIGGSRLCW MSLKQLQFIQ PSEFRLAGAP DISPCPQSRK
DALFVKAHEV FRNTSNVGEY YYLIRPYLGG APLEELQYLA QANISMDIDT FTNLNPLTLK
SMGVDSVRNL LGQNLGDLRK ARNHPNVILW MHSHNMTDLS DMGLYTSPTQ AYVANRPPNT
AYPPSSLIHS LDPPGNDGVS HTSGSPPVHL GYLSLAVALP SSLLWLLLCQ LPSGQMATAH
RTLGPMALAQ GSWTPEHQIP EKRSC
