ID   MSMB2_PROFL             Reviewed;         109 AA.
AC   A7VN14;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Small serum protein 2;
DE            Short=SSP-2;
DE   Flags: Precursor;
OS   Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX   NCBI_TaxID=88087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-69, SUBUNIT WITH
RP   TRIFLIN, AND MASS SPECTROMETRY.
RC   TISSUE=Liver, and Serum;
RX   PubMed=17543280; DOI=10.1016/j.bbrc.2007.05.091;
RA   Aoki N., Sakiyama A., Deshimaru M., Terada S.;
RT   "Identification of novel serum proteins in a Japanese viper: homologs of
RT   mammalian PSP94.";
RL   Biochem. Biophys. Res. Commun. 359:330-334(2007).
RN   [2]
RP   SUBUNIT WITH SEROTRIFLIN.
RC   TISSUE=Serum;
RX   PubMed=18222185; DOI=10.1016/j.bbapap.2007.12.010;
RA   Aoki N., Sakiyama A., Kuroki K., Maenaka K., Kohda D., Deshimaru M.,
RA   Terada S.;
RT   "Serotriflin, a CRISP family protein with binding affinity for small serum
RT   protein-2 in snake serum.";
RL   Biochim. Biophys. Acta 1784:621-628(2008).
CC   -!- FUNCTION: May serve as a self-defense protein against the toxic effects
CC       of the snake venom during accidental envenomation. Does not show
CC       inhibitory activity towards brevilysin H6.
CC   -!- SUBUNIT: Forms a stable, non-covalent complex with serotriflin.
CC       {ECO:0000269|PubMed:17543280, ECO:0000269|PubMed:18222185}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=9916.7; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:17543280};
CC   -!- SIMILARITY: Belongs to the beta-microseminoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AB360907; BAF80052.1; -; mRNA.
DR   PDB; 6IMF; X-ray; 2.30 A; B=1-109.
DR   PDBsum; 6IMF; -.
DR   AlphaFoldDB; A7VN14; -.
DR   SMR; A7VN14; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008735; PSP94.
DR   PANTHER; PTHR10500; PTHR10500; 1.
DR   Pfam; PF05825; PSP94; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:17543280"
FT   CHAIN           20..109
FT                   /note="Small serum protein 2"
FT                   /id="PRO_5000270321"
FT   DISULFID        21..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..71
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..107
FT                   /evidence="ECO:0000250"
FT   STRAND          21..24
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          52..55
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          59..65
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          68..73
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          77..80
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          84..89
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   TURN            90..93
FT                   /evidence="ECO:0007829|PDB:6IMF"
FT   STRAND          94..101
FT                   /evidence="ECO:0007829|PDB:6IMF"
SQ   SEQUENCE   109 AA;  12125 MW;  EE8F3729833D7DF9 CRC64;
     MRVFFSLIIF SFMLATCQGA CGIGPLVSSP TDAMAPKKCV DPNDRRKHLI VSTWNTADCL
     RCECDNDGLS CCHRYGGLAE RAGCKSVLNQ VTCEYEFYRL DDLSKRCDA