ID   MSME_STRMU              Reviewed;         420 AA.
AC   Q00749;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Multiple sugar-binding protein;
DE   Flags: Precursor;
GN   Name=msmE {ECO:0000303|PubMed:1537846}; OrderedLocusNames=SMU_878;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=Ingbritt;
RX   PubMed=1537846; DOI=10.1016/s0021-9258(18)42880-3;
RA   Russell R.R.B., Aduse-Opoku J., Sutcliffe I.C., Tao L., Ferretti J.J.;
RT   "A binding protein-dependent transport system in Streptococcus mutans
RT   responsible for multiple sugar metabolism.";
RL   J. Biol. Chem. 267:4631-4637(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Involved in a binding protein-dependent transport system
CC       responsible for the uptake of melibiose, raffinose and isomaltotriose.
CC       {ECO:0000269|PubMed:1537846}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- INDUCTION: By raffinose. {ECO:0000269|PubMed:1537846}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M77351; AAA26934.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58593.1; -; Genomic_DNA.
DR   PIR; B42400; B42400.
DR   RefSeq; NP_721287.1; NC_004350.2.
DR   RefSeq; WP_002262872.1; NC_004350.2.
DR   AlphaFoldDB; Q00749; -.
DR   SMR; Q00749; -.
DR   STRING; 210007.SMU_878; -.
DR   TCDB; 3.A.1.1.28; the atp-binding cassette (abc) superfamily.
DR   PRIDE; Q00749; -.
DR   EnsemblBacteria; AAN58593; AAN58593; SMU_878.
DR   KEGG; smu:SMU_878; -.
DR   PATRIC; fig|210007.7.peg.784; -.
DR   eggNOG; COG1653; Bacteria.
DR   HOGENOM; CLU_031285_12_3_9; -.
DR   OMA; FQEWAKA; -.
DR   PhylomeDB; Q00749; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR006059; SBP.
DR   InterPro; IPR006061; SBP_1_CS.
DR   Pfam; PF01547; SBP_bac_1; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS01037; SBP_BACTERIAL_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal; Sugar transport; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           23..420
FT                   /note="Multiple sugar-binding protein"
FT                   /id="PRO_0000031702"
FT   LIPID           23
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           23
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CONFLICT        27..28
FT                   /note="KA -> NG (in Ref. 1; AAA26934)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        33
FT                   /note="E -> D (in Ref. 1; AAA26934)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        277..287
FT                   /note="ALPAIKQQDPK -> PCQLLNNKIPN (in Ref. 1; AAA26934)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        372
FT                   /note="D -> H (in Ref. 1; AAA26934)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        388
FT                   /note="F -> L (in Ref. 1; AAA26934)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   420 AA;  47087 MW;  FA7CF7AEC63DEFA7 CRC64;
     MKWYKKIGLL GIVGLTSVLL AACNKSKASQ SKEDKVTIEY FNQKKEMDAT LKKIIKDFER
     ENPKIHVKMT SVPDAGTVLK TRVLSGDVPD VINIYPQNMD FQEWSKAGYF YNMTGKAYLN
     HLKNHYANEY KVNQKVYSVP LTANVSGIYY NKTKFKELGL KVPETWDEFV KLVEEIKAKK
     ETPFALAGTE GWTLNGYHQL SLISVTGSAN AANKYLRFSQ PNSIKTSDKI LKEDMVRLNL
     LADDGNQQKN WKGASYNDAL VAFANEKALM TPNGSWALPA IKQQDPKFEI GTFAFPGKKT
     GNGITVGAGD LALSISAKTK HLKEAEKFVK YMTTARAMQK YYDVDGSPVA VKGVREDKNS
     PLQPLTKLAF TDKHYVWLGQ HWNSEDDFFT ATTNYLMTKN AKGLADGLNA FFNPMKADVD